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Literature summary extracted from

  • Ide, T.; Baumer, S.; Deppenmeier, U.
    Energy conservation by the H2:heterodisulfide oxidoreductase from Methanosarcina mazei G๖1: identification of two proton-translocating segments (1999), J. Bacteriol., 181, 4076-4080.
    View publication on PubMedView publication on EuropePMC

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.8.98.1 membrane bound to Methanosarcina mazei 16020
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Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.8.98.1 N-(7-[(2-sulfoethyl)dithio]heptanoyl)-3-O-phospho-L-threonine + H2 Methanosarcina mazei reaction is coupled with transfer of protons across the cytoplasmic membrane. The electrochemical proton gradient thereby generated drives ATP synthesis from ADP plus phosphate. Two different proton-translocating segments are present in the H2:heterodisulfide oxidoreductase system. The first involves the 2-hydroxyphenazine-dependent hydrogenase, and the second involves the heterodisulfide reductase coenzyme B + coenzyme M
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 ?

Organism

EC Number Organism UniProt Comment Textmining
1.8.98.1 Methanosarcina mazei
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 Gรถ1
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.8.98.1 N-(7-[(2-sulfoethyl)dithio]heptanoyl)-3-O-phospho-L-threonine + dihydro-2-hydroxyphenazine
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 Methanosarcina mazei coenzyme B + coenzyme M
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 ?
1.8.98.1 N-(7-[(2-sulfoethyl)dithio]heptanoyl)-3-O-phospho-L-threonine + H2
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 Methanosarcina mazei coenzyme B + coenzyme M
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 ?
1.8.98.1 N-(7-[(2-sulfoethyl)dithio]heptanoyl)-3-O-phospho-L-threonine + H2 reaction is coupled with transfer of protons across the cytoplasmic membrane. The electrochemical proton gradient thereby generated drives ATP synthesis from ADP plus phosphate. Two different proton-translocating segments are present in the H2:heterodisulfide oxidoreductase system. The first involves the 2-hydroxyphenazine-dependent hydrogenase, and the second involves the heterodisulfide reductase Methanosarcina mazei coenzyme B + coenzyme M
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 ?

Synonyms

EC Number Synonyms Comment Organism
1.8.98.1 H2:heterodisulfide oxidoreductase
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 Methanosarcina mazei