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Literature summary extracted from

  • Miyadera, H.; Shiomi, K.; Ui, H.; Yamaguchi, Y.; Masuma, R.; Tomoda, H.; Miyoshi, H.; Osanai, A.; Kita, K.; Omura, S.
    Atpenins, potent and specific inhibitors of mitochondrial complex II (succinate-ubiquinone oxidoreductase) (2003), Proc. Natl. Acad. Sci. USA, 100, 473-477.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.3.5.1 2-heptyl-4-hydroxyquinoline N-oxide more than 0.1 mM, 50% inhibition Bos taurus
1.3.5.1 4,4,4-trifluoro-1-(2-thienyl)-1,3-butanedione 0.006 mM, 50% inhibition Bos taurus
1.3.5.1 atpenin A4 0.00001 mM, 50% inhibition Bos taurus
1.3.5.1 atpenin A4 0.000024 mM, 50% inhibition Rattus norvegicus
1.3.5.1 atpenin A5 0.000004 mM, 50% inhibition Bos taurus
1.3.5.1 atpenin A5 0.000004 mM, 50% inhibition Rattus norvegicus
1.3.5.1 carboxin 0.001 mM, 50% inhibition Bos taurus
1.3.5.1 harzianopyridone 0.00002 mM, 50% inhibition Bos taurus
1.3.5.1 harzianopyridone 0.0002 mM, 50% inhibition Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.3.5.1 membrane
-
 Bos taurus 16020
-
1.3.5.1 mitochondrion
-
 Rattus norvegicus 5739
-
1.3.5.1 mitochondrion
-
 Bos taurus 5739
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.3.5.1 succinate + ubiquinone Rattus norvegicus
-
 fumarate + ubiquinol
-
 ?
1.3.5.1 succinate + ubiquinone Bos taurus
-
 fumarate + ubiquinol
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.3.5.1 Bos taurus
-
-
-
1.3.5.1 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.3.5.1 heart
-
 Bos taurus
-
1.3.5.1 liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.5.1 succinate + 2,3-dimethoxy-5-methyl-6-geranyl-1,4-benzoquinone
-
 Rattus norvegicus fumarate + 2,3-dimethoxy-5-methyl-6-geranyl-1,4-benzoquinol
-
 ?
1.3.5.1 succinate + 2,3-dimethoxy-5-methyl-6-geranyl-1,4-benzoquinone
-
 Bos taurus fumarate + 2,3-dimethoxy-5-methyl-6-geranyl-1,4-benzoquinol
-
 ?
1.3.5.1 succinate + ubiquinone
-
 Rattus norvegicus fumarate + ubiquinol
-
 ?
1.3.5.1 succinate + ubiquinone
-
 Bos taurus fumarate + ubiquinol
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.3.5.1 complex II
-
 Bos taurus
1.3.5.1 SQR
-
 Rattus norvegicus
1.3.5.1 SQR
-
 Bos taurus

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.3.5.1 0.000001
-
 atpenin A5 25°C, pH 7.5 Bos taurus
1.3.5.1 0.000007
-
 atpenin A4 25°C, pH 7.5 Bos taurus
1.3.5.1 0.000007
-
 harzianopyridone 25°C, pH 7.5 Bos taurus