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Literature summary extracted from

  • Weid, M.; Ziegler, J.; Kutchan, T.M.
    The roles of latex and the vascular bundle in morphine biosynthesis in the opium poppy, Papaver somniferum (2004), Proc. Natl. Acad. Sci. USA, 101, 13957-13962.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.21.3.3 expressed in Escherichia coli BL21 Papaver somniferum
1.21.3.3 expressed in Spodoptera frugiperda (Sf9) Eschscholzia californica

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.21.3.3 vesicle smooth vesicle with basic pH Eschscholzia californica 31982
-
1.21.3.3 vesicle smooth vesicle with basic pH Papaver somniferum 31982
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.21.3.3 (S)-reticuline + O2 Eschscholzia californica first step of isoquinoline and benzophenanthridine alkaloid biosynthesis, involved in sanguinarine pathway (S)-scoulerine + H2O2
-
 ?
1.21.3.3 (S)-reticuline + O2 Papaver somniferum first step of isoquinoline and benzophenanthridine alkaloid biosynthesis, involved in sanguinarine pathway (S)-scoulerine + H2O2
-
 ?
2.1.1.116 additional information Papaver somniferum the enzyme is central to the biosynthesis of tetrahydroisoquinoline-derived alkaloids ?
-
 ?
2.3.1.150 acetyl-CoA + salutaridinol Papaver somniferum involved in morphine biosynthesis CoA + 7-O-acetylsalutaridinol
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.247 Papaver somniferum
-
-
-
1.21.3.3 Eschscholzia californica
-
-
-
1.21.3.3 Papaver somniferum
-
-
-
2.1.1.116 Papaver somniferum
-
-
-
2.1.1.291 Papaver somniferum
-
-
-
2.3.1.150 Papaver somniferum
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.247 additional information laticifers are not found in developing root tip, and likewise, codeinone reductase is not detected Papaver somniferum
-
1.1.1.247 plant capsule localized in laticifers Papaver somniferum
-
1.1.1.247 stem localized in laticifers Papaver somniferum
-
1.21.3.3 idioblast
-
 Eschscholzia californica
-
1.21.3.3 idioblast
-
 Papaver somniferum
-
1.21.3.3 additional information not detectable in capsule and leaf Eschscholzia californica
-
1.21.3.3 root parenchyma cells of root cortex Eschscholzia californica
-
1.21.3.3 root parenchyma cells of root cortex Papaver somniferum
-
1.21.3.3 stem
-
 Eschscholzia californica
-
2.1.1.116 parenchymal cell
-
 Papaver somniferum
-
2.1.1.116 pericycle
-
 Papaver somniferum
-
2.1.1.116 plant capsule predominantly in parenchyma cells within the vascular bundle Papaver somniferum
-
2.1.1.116 root in developing root tip the enzyme is found in the pericycle of the stele Papaver somniferum
-
2.1.1.116 stem predominantly in parenchyma cells within the vascular bundle Papaver somniferum
-
2.1.1.291 fruit capsule the enzyme is found predominantly in parenchyma cells within the vascular bundle Papaver somniferum
-
2.1.1.291 root the enzyme is found in the pericycle within the stele Papaver somniferum
-
2.1.1.291 stem the enzyme is found predominantly in parenchyma cells within the vascular bundle Papaver somniferum
-
2.1.1.291 vascular bundle the enzyme is found predominantly in parenchyma cells within the vascular bundle Papaver somniferum
-
2.3.1.150 plant capsule
-
 Papaver somniferum
-
2.3.1.150 stele in developing root tips Papaver somniferum
-
2.3.1.150 stem
-
 Papaver somniferum
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.21.3.3 (S)-reticuline + O2
-
 Eschscholzia californica (S)-scoulerine + H2O2
-
 ?
1.21.3.3 (S)-reticuline + O2
-
 Papaver somniferum (S)-scoulerine + H2O2
-
 ?
1.21.3.3 (S)-reticuline + O2 first step of isoquinoline and benzophenanthridine alkaloid biosynthesis, involved in sanguinarine pathway Eschscholzia californica (S)-scoulerine + H2O2
-
 ?
1.21.3.3 (S)-reticuline + O2 first step of isoquinoline and benzophenanthridine alkaloid biosynthesis, involved in sanguinarine pathway Papaver somniferum (S)-scoulerine + H2O2
-
 ?
2.1.1.116 additional information the enzyme is central to the biosynthesis of tetrahydroisoquinoline-derived alkaloids Papaver somniferum ?
-
 ?
2.3.1.150 acetyl-CoA + salutaridinol
-
 Papaver somniferum CoA + 7-O-acetylsalutaridinol
-
 ?
2.3.1.150 acetyl-CoA + salutaridinol involved in morphine biosynthesis Papaver somniferum CoA + 7-O-acetylsalutaridinol
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.1.1.116 (R,S)-3'-hydroxy-N-methylcoclaurine 4'-O-methyltransferase
-
 Papaver somniferum
2.3.1.150 SalAT
-
 Papaver somniferum

pH Range

EC Number pH Minimum pH Maximum Comment Organism
1.21.3.3 9 10 completely inactive at acidic or neutral pH Eschscholzia californica
1.21.3.3 9 10 completely inactive at acidic or neutral pH Papaver somniferum