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Literature summary extracted from

  • Frederiks, W.M.; Vreeling-Sindelarova, H.
    Ultrastructural localization of xanthine oxidoreductase activity in isolated rat liver cells (2002), Acta Histochem., 104, 29-37.
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.17.1.4 cytoplasm parenchymal cells, dehydrogenase activity Rattus norvegicus 5737
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1.17.1.4 peroxisome matrix and core, of parenchymal cells, both oxidase and dehydrogenase activity Rattus norvegicus 5777
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1.17.3.2 additional information only XOR activity is present in the cytoplasm of rat liver parenchymal cells. In Kupffer cells and sinusoidal endothelial cell xanthine oxidoreductase activity is demonstrated in vesicles and occasionally on granular endoplasmic reticulum. Xanthine oxidase activity is not found in Kupffer cells and sinusoidal cells Rattus norvegicus
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1.17.3.2 peroxisome matrix and core of peroxisomes of liver parenchymal cells, xanthine oxidoreductase and xanthine oxidase detected Rattus norvegicus 5777
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Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.17.1.4 additional information Rattus norvegicus major function of enzyme in liver parenchymal and sinusoidal cells is the production of uric acid as a antioxidant ?
-
 ?
1.17.3.2 xanthine + H2O + O2 Rattus norvegicus xanthine oxidoreductase, XOR, can exist in a dehydrogenase form, XD, and an oxidase form, XO. Part of total XOR activity in peroxisomes is XO activity. The major function of XOR activity in the cytoplasm of rat liver parenchymal cells and in sinusoidal cells is not the production of O2 radicals, but rather the production of uric acid which can act as a potent antioxidant urate + H2O2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.17.1.4 Rattus norvegicus
-
-
-
1.17.3.2 Rattus norvegicus
-
 xanthine oxidoreductase can exists in a dehydrogenase form, XD, and in an oxidase form, XO
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Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.17.1.4 liver isolated cells of liver Rattus norvegicus
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1.17.3.2 liver
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 Rattus norvegicus
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1.17.3.2 parenchymal cell
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 Rattus norvegicus
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.17.1.4 additional information major function of enzyme in liver parenchymal and sinusoidal cells is the production of uric acid as a antioxidant Rattus norvegicus ?
-
 ?
1.17.3.2 xanthine + H2O + O2
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 Rattus norvegicus urate + H2O2
-
 ?
1.17.3.2 xanthine + H2O + O2 xanthine oxidoreductase, XOR, can exist in a dehydrogenase form, XD, and an oxidase form, XO. Part of total XOR activity in peroxisomes is XO activity. The major function of XOR activity in the cytoplasm of rat liver parenchymal cells and in sinusoidal cells is not the production of O2 radicals, but rather the production of uric acid which can act as a potent antioxidant Rattus norvegicus urate + H2O2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.17.3.2 xanthine oxidoreductase xanthine oxidoreductase can exists in a dehydrogenase form, XD, and an oxidase form, XO Rattus norvegicus
1.17.3.2 XO
-
 Rattus norvegicus
1.17.3.2 XOR xanthine oxidoreductase can exists in a dehydrogenase form, XD, and an oxidase form, XO Rattus norvegicus