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Literature summary extracted from

  • Leduc, D.; Graziani, S.; Meslet-Cladiere, L.; Sodolescu, A.; Liebl, U.; Myllykallio, H.
    Two distinct pathways for thymidylate (dTMP) synthesis in (hyper)thermophilic bacteria and archaea (2004), Biochem. Soc. Trans., 32, 231-235.
    View publication on PubMed

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.45 Archaeoglobus fulgidus
-
-
-
2.1.1.45 Methanocaldococcus jannaschii
-
-
-
2.1.1.45 Methanopyrus kandleri
-
 AV19
-
2.1.1.45 Methanothermobacter thermautotrophicus
-
-
-
2.1.1.45 no activity in Aeropyrum pernix
-
-
-
2.1.1.45 no activity in Aquifex aeolicus
-
-
-
2.1.1.45 no activity in Pyrobaculum aerophilum
-
-
-
2.1.1.45 no activity in Pyrococcus abyssi
-
-
-
2.1.1.45 no activity in Pyrococcus furiosus
-
 DSM 3638
-
2.1.1.45 no activity in Pyrococcus horikoshii
-
-
-
2.1.1.45 no activity in Sulfolobus solfataricus
-
-
-
2.1.1.45 no activity in Sulfolobus tokodaii
-
-
-
2.1.1.45 no activity in Thermoplasma acidophilum
-
-
-
2.1.1.45 no activity in Thermoplasma volcanium
-
-
-
2.1.1.45 no activity in Thermotoga maritima
-
-
-
2.1.1.148 Aeropyrum pernix
-
-
-
2.1.1.148 Aquifex aeolicus
-
-
-
2.1.1.148 no activity in Archaeoglobus fulgidus
-
-
-
2.1.1.148 no activity in Methanocaldococcus jannaschii
-
-
-
2.1.1.148 no activity in Methanopyrus kandleri
-
 AV19
-
2.1.1.148 no activity in Methanopyrus kandleri AV19
-
 AV19
-
2.1.1.148 no activity in Methanothermobacter thermoautotrophicus
-
-
-
2.1.1.148 Pyrobaculum aerophilum
-
-
-
2.1.1.148 Pyrococcus abyssi
-
-
-
2.1.1.148 Pyrococcus furiosus
-
 DSM 3638
-
2.1.1.148 Pyrococcus horikoshii
-
-
-
2.1.1.148 Saccharolobus solfataricus
-
-
-
2.1.1.148 Sulfurisphaera tokodaii
-
-
-
2.1.1.148 Thermoplasma acidophilum
-
-
-
2.1.1.148 Thermoplasma volcanium
-
-
-
2.1.1.148 Thermotoga maritima
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.45 5,10-methylenetetrahydrofolate + dUMP
-
 Methanothermobacter thermautotrophicus dihydrofolate + dTMP
-
 ?
2.1.1.45 5,10-methylenetetrahydrofolate + dUMP
-
 Methanocaldococcus jannaschii dihydrofolate + dTMP
-
 ?
2.1.1.45 5,10-methylenetetrahydrofolate + dUMP
-
 Archaeoglobus fulgidus dihydrofolate + dTMP
-
 ?
2.1.1.45 5,10-methylenetetrahydrofolate + dUMP
-
 Methanopyrus kandleri dihydrofolate + dTMP
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.1.1.45 ThyA
-
 Methanothermobacter thermautotrophicus
2.1.1.45 ThyA
-
 Methanocaldococcus jannaschii
2.1.1.45 ThyA
-
 Archaeoglobus fulgidus
2.1.1.45 ThyA
-
 Methanopyrus kandleri
2.1.1.148 ThyX
-
 Pyrococcus furiosus
2.1.1.148 ThyX
-
 Thermoplasma acidophilum
2.1.1.148 ThyX
-
 Saccharolobus solfataricus
2.1.1.148 ThyX
-
 Thermotoga maritima
2.1.1.148 ThyX
-
 Pyrococcus horikoshii
2.1.1.148 ThyX
-
 Pyrobaculum aerophilum
2.1.1.148 ThyX
-
 Aquifex aeolicus
2.1.1.148 ThyX
-
 Aeropyrum pernix
2.1.1.148 ThyX
-
 Thermoplasma volcanium
2.1.1.148 ThyX
-
 Sulfurisphaera tokodaii
2.1.1.148 ThyX
-
 Pyrococcus abyssi

Cofactor

EC Number Cofactor Comment Organism Structure
2.1.1.148 FAD
-
 Pyrococcus furiosus
2.1.1.148 FAD
-
 Thermoplasma acidophilum
2.1.1.148 FAD
-
 Saccharolobus solfataricus
2.1.1.148 FAD
-
 Thermotoga maritima
2.1.1.148 FAD
-
 Pyrococcus horikoshii
2.1.1.148 FAD
-
 Pyrobaculum aerophilum
2.1.1.148 FAD
-
 Aquifex aeolicus
2.1.1.148 FAD
-
 Aeropyrum pernix
2.1.1.148 FAD
-
 Thermoplasma volcanium
2.1.1.148 FAD
-
 Sulfurisphaera tokodaii
2.1.1.148 FAD
-
 Pyrococcus abyssi
2.1.1.148 NADPH
-
 Pyrococcus furiosus
2.1.1.148 NADPH
-
 Thermoplasma acidophilum
2.1.1.148 NADPH
-
 Saccharolobus solfataricus
2.1.1.148 NADPH
-
 Thermotoga maritima
2.1.1.148 NADPH
-
 Pyrococcus horikoshii
2.1.1.148 NADPH
-
 Pyrobaculum aerophilum
2.1.1.148 NADPH
-
 Aquifex aeolicus
2.1.1.148 NADPH
-
 Aeropyrum pernix
2.1.1.148 NADPH
-
 Thermoplasma volcanium
2.1.1.148 NADPH
-
 Sulfurisphaera tokodaii
2.1.1.148 NADPH
-
 Pyrococcus abyssi