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Literature summary extracted from

  • Grivennikova, V.G.; Roth, R.; Zakharova, N.V.; Hagerhall, C.; Vinogradov, A.D.
    The mitochondrial and prokaryotic proton-translocating NADH:ubiquinone oxidoreductases: similarities and dissimilarities of the quinone-junction sites (2003), Biochim. Biophys. Acta, 1607, 79-90.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
7.1.1.2 ADP-ribose competitive with NADH Bos taurus
7.1.1.2 ADP-ribose competitive with NADH Paracoccus denitrificans
7.1.1.2 rotenone
-
 Bos taurus
7.1.1.2 rotenone inhibition of NADH oxidation, NAD+ reduction is not inhibited by 0.001 mM rotenone Paracoccus denitrificans
7.1.1.2 rotenone
-
 Rhodobacter capsulatus
7.1.1.2 Triton X-100
-
 Bos taurus
7.1.1.2 Triton X-100
-
 Paracoccus denitrificans
7.1.1.2 Triton X-100
-
 Rhodobacter capsulatus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
7.1.1.2 0.0014
-
 NADH coupled oxidase reaction, pH 8.0, 25°C Bos taurus
7.1.1.2 0.002
-
 NADH coupled oxidase reaction, pH 8.0, 25°C Paracoccus denitrificans
7.1.1.2 0.0022
-
 NADH uncoupled oxidase reaction, pH 8.0, 25°C Bos taurus
7.1.1.2 0.006
-
 NADH uncoupled oxidase reaction, pH 8.0, 25°C Rhodobacter capsulatus
7.1.1.2 0.007
-
 NAD+ pH 8.0, 25°C, succinate supported NAD+ reduction Bos taurus
7.1.1.2 0.007
-
 NADH uncoupled oxidase reaction, pH 8.0, 25°C Paracoccus denitrificans
7.1.1.2 0.01
-
 coenzyme Q1 pH 8.0, 25°C Bos taurus
7.1.1.2 0.015
-
 coenzyme Q1 pH 8.0, 25°C Rhodobacter capsulatus
7.1.1.2 0.02
-
 coenzyme Q1 pH 8.0, 25°C Paracoccus denitrificans
7.1.1.2 0.27
-
 NAD+ pH 8.0, 25°C, succinate supported NAD+ reduction Paracoccus denitrificans

Organism

EC Number Organism UniProt Comment Textmining
7.1.1.2 Bos taurus
-
-
-
7.1.1.2 Paracoccus denitrificans
-
-
-
7.1.1.2 Rhodobacter capsulatus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
7.1.1.2 heart
-
 Bos taurus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
7.1.1.2 NADH + H+ + coenzyme Q1
-
 Paracoccus denitrificans NAD+ + reduced coenzyme Q1
-
 ?
7.1.1.2 NADH + H+ + coenzyme Q1
-
 Bos taurus NAD+ + reduced coenzyme Q1
-
 ?
7.1.1.2 NADH + H+ + coenzyme Q1
-
 Rhodobacter capsulatus NAD+ + reduced coenzyme Q1
-
 ?

Synonyms

EC Number Synonyms Comment Organism
7.1.1.2 complex I
-
 Paracoccus denitrificans
7.1.1.2 complex I
-
 Bos taurus
7.1.1.2 complex I
-
 Rhodobacter capsulatus
7.1.1.2 NADH:ubiquinone oxidoreductase
-
 Paracoccus denitrificans
7.1.1.2 NADH:ubiquinone oxidoreductase
-
 Bos taurus
7.1.1.2 NADH:ubiquinone oxidoreductase
-
 Rhodobacter capsulatus

Cofactor

EC Number Cofactor Comment Organism Structure
7.1.1.2 NADH
-
 Paracoccus denitrificans
7.1.1.2 NADH
-
 Bos taurus
7.1.1.2 NADH
-
 Rhodobacter capsulatus

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
7.1.1.2 0.000001
-
 rotenone pH 8.0, 25°C, NADH oxidase reaction Bos taurus
7.1.1.2 0.00002
-
 rotenone pH 8.0, 25°C, NAD+ reduction Bos taurus
7.1.1.2 0.00015
-
 rotenone pH 8.0, 25°C, NADH oxidase reaction Rhodobacter capsulatus
7.1.1.2 0.0005
-
 rotenone pH 8.0, 25°C, NADH oxidase reaction Paracoccus denitrificans
7.1.1.2 0.007
-
 Triton X-100 pH 8.0, 25°C, NADH oxidase reaction Bos taurus
7.1.1.2 0.01
-
 Triton X-100 pH 8.0, 25°C, NAD+ reduction Paracoccus denitrificans
7.1.1.2 0.025
-
 ADP-ribose pH 8.0, 25°C Bos taurus
7.1.1.2 0.025
-
 Triton X-100 pH 8.0, 25°C, NADH oxidase reaction Rhodobacter capsulatus
7.1.1.2 0.04
-
 Triton X-100 pH 8.0, 25°C, NAD+ reduction Bos taurus
7.1.1.2 0.05
-
 Triton X-100 pH 8.0, 25°C, NADH oxidase reaction Paracoccus denitrificans
7.1.1.2 0.08
-
 ADP-ribose pH 8.0, 25°C Paracoccus denitrificans