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Literature summary extracted from

  • Cai, Y.; Cronin, C.N.; Engel, A.G.; Ohno, K.; Hersh, L.B.; Rodgers, D.W.
    Choline acetyltransferase structure reveals distribution of mutations that cause motor disorders (2004), EMBO J., 23, 2047-2058.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.3.1.6 residues 18-617 of full length DNA expressed in Escherichia coli DH5alphaF’IQ Rattus norvegicus

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
2.3.1.6 sitting drop vapor diffusion method Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.1.6 membrane
-
 Rattus norvegicus 16020
-
2.3.1.6 soluble primary form Rattus norvegicus
-
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.3.1.6 additional information metal binding site found in crystal structure analysis, bound metal is most likely a Na+ Rattus norvegicus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.3.1.6 68000
-
 gel filtration Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.6 acetyl-CoA + choline Rattus norvegicus synthesis of the neurotransmitter acetylcholine, mutations in ChAT causes congenital neuromuscular disorders acetylcholine + CoA
-
 r

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.6 Rattus norvegicus P32738
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
2.3.1.6 phosphoprotein regulation of activity by phosphorylation Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.6 neuron
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.6 acetyl-CoA + choline
-
 Rattus norvegicus acetylcholine + CoA
-
 r
2.3.1.6 acetyl-CoA + choline synthesis of the neurotransmitter acetylcholine, mutations in ChAT causes congenital neuromuscular disorders Rattus norvegicus acetylcholine + CoA
-
 r