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Literature summary extracted from

  • Hedderich, R.
    Energy-converting [NiFe] hydrogenases from archaea and extremophiles: ancestors of complex I (2004), J. Bioenerg. Biomembr., 36, 65-75.
    View publication on PubMed

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.12.7.2 0.005
-
 H2
-
 Methanosarcina barkeri

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.12.7.2 integral to membrane
-
 Methanosarcina barkeri
-
-
1.12.7.2 membrane
-
 Pyrococcus furiosus 16020
-
1.12.7.2 membrane
-
 Caldanaerobacter subterraneus subsp. tengcongensis 16020
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.12.7.2 Fe contains [4Fe-4S] clusters Methanosarcina barkeri
1.12.7.2 Fe NiFe hydrogenase Pyrococcus furiosus
1.12.7.2 Ni contains NiFe centers Methanosarcina barkeri
1.12.7.2 Ni NiFe hydrogenase Pyrococcus furiosus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.12.7.2 H+ + reduced ferredoxin Pyrococcus furiosus Mbh function as a redox-driven ion pump coupling the reduction of protons with electrons derived from the oxidation of a low-potential ferredoxin to the generation of a H+ motive force H2 + oxidized ferredoxin
-
 ?
1.12.7.2 H+ + reduced ferredoxin Caldanaerobacter subterraneus subsp. tengcongensis reaction is proposed to be coupled to energy conservation H2 + oxidized ferredoxin
-
 ?
1.12.7.2 H2 + oxidized ferredoxin Methanosarcina barkeri enzyme is absolutely required for the reduction of CO2 to formylmethanofuran by H2, Ech hydrogenase provides the cell with reduced ferredoxin required as electron donor reduced ferredoxin + H+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.12.7.2 Caldanaerobacter subterraneus subsp. tengcongensis
-
-
-
1.12.7.2 Methanosarcina barkeri
-
-
-
1.12.7.2 Pyrococcus furiosus
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.12.7.2 H+ + reduced ferredoxin
-
 Pyrococcus furiosus H2 + oxidized ferredoxin
-
 ?
1.12.7.2 H+ + reduced ferredoxin
-
 Caldanaerobacter subterraneus subsp. tengcongensis H2 + oxidized ferredoxin
-
 ?
1.12.7.2 H+ + reduced ferredoxin Mbh function as a redox-driven ion pump coupling the reduction of protons with electrons derived from the oxidation of a low-potential ferredoxin to the generation of a H+ motive force Pyrococcus furiosus H2 + oxidized ferredoxin
-
 ?
1.12.7.2 H+ + reduced ferredoxin reaction is proposed to be coupled to energy conservation Caldanaerobacter subterraneus subsp. tengcongensis H2 + oxidized ferredoxin
-
 ?
1.12.7.2 H+ + reduced methyl viologen
-
 Pyrococcus furiosus H2 + oxidized methyl viologen
-
 ?
1.12.7.2 H2 + oxidized ferredoxin
-
 Methanosarcina barkeri reduced ferredoxin + H+
-
 ?
1.12.7.2 H2 + oxidized ferredoxin enzyme is absolutely required for the reduction of CO2 to formylmethanofuran by H2, Ech hydrogenase provides the cell with reduced ferredoxin required as electron donor Methanosarcina barkeri reduced ferredoxin + H+
-
 ?

Subunits

EC Number Subunits Comment Organism
1.12.7.2 hexamer
-
 Methanosarcina barkeri

Synonyms

EC Number Synonyms Comment Organism
1.12.7.2 Ech hydrogenase
-
 Methanosarcina barkeri
1.12.7.2 Mbh
-
 Pyrococcus furiosus
1.12.7.2 membrane bound NiFe hydrogenase
-
 Pyrococcus furiosus