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Literature summary extracted from

  • Covian, R.; Gutierrez-Cirlos, E.B.; Trumpower, B.L.
    Anti-cooperative oxidation of ubiquinol by the yeast cytochrome bc1 complex (2004), J. Biol. Chem., 279, 15040-15049.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
7.1.1.8 Antimycin stimulation at low inhibitor/enzyme ratio Saccharomyces cerevisiae
7.1.1.8 ilicicolin stimulation at low inhibitor/enzyme ratio Saccharomyces cerevisiae

Protein Variants

EC Number Protein Variants Comment Organism
7.1.1.8 Y185F iron-sulfur protein mutant, pre-steady-state and steady-­state kinetic analysis in comparison to the wild-type enzyme Saccharomyces cerevisiae

Inhibitors

EC Number Inhibitors Comment Organism Structure
7.1.1.8 Antimycin due to half-of-sites mechanism of the enzyme, 1 inhibitor molecule per enzyme complex dimer is sufficient for inhibition, center N inhibitor Saccharomyces cerevisiae
7.1.1.8 ilicicolin H center N inhibitor Saccharomyces cerevisiae

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
7.1.1.8 additional information
-
 additional information pre-steady-state and steady-state kinetics, kinetic modeling, kinetics of interactions between monomers of the dimeric enzyme complex, pH 7.0 and pH 8.8 Saccharomyces cerevisiae

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
7.1.1.8 Iron enzyme complex contains an iron-sulfur protein, and heme groups in the cytochrome molecules Saccharomyces cerevisiae

Organism

EC Number Organism UniProt Comment Textmining
7.1.1.8 Saccharomyces cerevisiae
-
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
7.1.1.8 quinol + 2 ferricytochrome c = quinone + 2 ferrocytochrome c + 2 H+[side 2] alternating half-of-sites mechanism of ubiquinol oxidation Saccharomyces cerevisiae
a

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
7.1.1.8 decyl-ubiquinol + ferricytochrome c anti-cooperative oxidation of ubiquinol, reversible partial reaction Saccharomyces cerevisiae decyl-ubiquinone + ferrocytochrome c
-
 ?
7.1.1.8 additional information electron transfer takes place between the 2 cytochrome b subunits Saccharomyces cerevisiae ?
-
 ?
7.1.1.8 ubiquinol-2 + 2 ferricytochrome c anti-cooperative oxidation of ubiquinol, reversible partial reaction Saccharomyces cerevisiae ubiquinone-2 + 2 ferrocytochrome c + 2 H+
-
 ?

Subunits

EC Number Subunits Comment Organism
7.1.1.8 More interaction analysis between monomers of the dimeric enzyme complex Saccharomyces cerevisiae

Synonyms

EC Number Synonyms Comment Organism
7.1.1.8 cytochrome bc1 complex
-
 Saccharomyces cerevisiae

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
7.1.1.8 7
-
 assay at Saccharomyces cerevisiae