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Literature summary extracted from

  • Li, H.; Samouilov, A.; Liu, X.; Zweier, J.L.
    Characterization of the effects of oxygen on xanthine oxidase-mediated nitric oxide formation (2004), J. Biol. Chem., 279, 16939-16946.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.17.3.2 diphenylene iodonium chloride strongly inhibits xanthine oxidase mediated NO generation with NADH serving as reducing substrate, with xanthine or 2,3-dihydroxybenzaldehyde as reducing substrates, NO generation is increased more than six times Bos taurus

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.17.3.2 diphenylene iodonium chloride strongly inhibits xanthine oxidase mediated NO generation with NADH serving as reducing substrate, with xanthine or 2,3-dihydroxybenzaldehyde as reducing substrates, NO generation is increased more than six times Bos taurus
1.17.3.2 O2 competitive inhibitor of NO production Bos taurus
1.17.3.2 oxypurinol inhibits NO generation triggered by xanthine, NADH or 2,3-dihydroxybenzaldehyde Bos taurus

Organism

EC Number Organism UniProt Comment Textmining
1.17.3.2 Bos taurus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.17.3.2 heart xanthine oxidase mediated nitrite reduction can be a source of NO in heart tissue under conditions of tissue normoxia, and it is further increased with mild hypoxia Bos taurus
-
1.17.3.2 milk
-
 Bos taurus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.17.3.2 nitrite + 2,3-dihydroxybenzaldehyde NO generation occurs under aerobic conditions and is regulated by O2 tension, pH, nitrite, and reducing substrate concentrations Bos taurus NO + ?
-
 ?
1.17.3.2 nitrite + NADH NO generation occurs under aerobic conditions and is regulated by O2 tension, pH, nitrite, and reducing substrate concentrations Bos taurus NO + NAD+ + H2O
-
 ?
1.17.3.2 nitrite + xanthine NO generation occurs under aerobic conditions and is regulated by O2 tension, pH, nitrite, and reducing substrate concentrations Bos taurus NO + ?
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.17.3.2 5
-
-
 Bos taurus

pH Range

EC Number pH Minimum pH Maximum Comment Organism
1.17.3.2 6 7.6 under aerobic conditions, NO generation increases more than three times as the pH value decreases from pH 7.4 to 6.0 Bos taurus