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Literature summary extracted from

  • Lee, I.; Salomon, A.R.; Ficarro, S.; Mathes, I.; Lottspeich, F.; Grossman, L.; Hüttemann, M.
    cAMP-dependent tyrosine phosphorylation of subunit I inhibits cytochrome c oxidase activity (2005), J. Biol. Chem., 280, 6094-6110.
    View publication on PubMed

Application

EC Number Application Comment Organism
7.1.1.9 medicine at therapeutic concentrations used for asthma relief, theophylline causes inhibition of the lung enzyme and decreases cellular ATP levels, suggesting a mechanism for its clinical action Bos taurus

Inhibitors

EC Number Inhibitors Comment Organism Structure
7.1.1.9 additional information cAMP-dependent tyrosine phosphorylation of subunit I inhibits cytochrome c oxidase activity Bos taurus
7.1.1.9 theophylline at therapeutic concentrations used for asthma relief, theophylline causes inhibition of the lung enzyme and decreases cellular ATP levels, suggesting a mechanism for its clinical action Bos taurus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
7.1.1.9 mitochondrion
-
 Bos taurus 5739
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
7.1.1.9 ferrocytochrome c + O2 Bos taurus terminal enzyme of the electron transport chain. The glucagon receptor/G-protein/c-AMP pathway regulates enzyme activity ferricytochrome c + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
7.1.1.9 Bos taurus
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
7.1.1.9 phosphoprotein cAMP-dependent tyrosine phosphorylation of subunit I inhibits cytochrome c oxidase activity Bos taurus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
7.1.1.9 liver
-
 Bos taurus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
7.1.1.9 ferrocytochrome c + O2 terminal enzyme of the electron transport chain. The glucagon receptor/G-protein/c-AMP pathway regulates enzyme activity Bos taurus ferricytochrome c + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
7.1.1.9 COX
-
 Bos taurus