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Literature summary extracted from

  • Lewis, R.M.; Godfrey, K.M.; Jackson, A.A.; Cameron, I.T.; Hanson, M.A.
    Low serine hydroxymethyltransferase activity in the human placenta has important implications for fetal glycine supply (2005), J. Clin. Endocrinol. Metab., 90, 1594-1598.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.2.1 L-Ser + tetrahydrofolate Ovis aries placental conversion of serine to glycine is a major source of fetal glycine Gly + 5,10-methylenetetrahydrofolate
-
 ?
2.1.2.1 additional information Homo sapiens low activity in placenta suggests that placental conversion of serine to glycine is not a major source of fetal glycine ?
-
 ?
2.1.2.1 additional information Rattus norvegicus low activity in placenta suggests that placental conversion of serine to glycine is not a major source of fetal glycine ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.1.2.1 Homo sapiens
-
-
-
2.1.2.1 Ovis aries
-
-
-
2.1.2.1 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.1.2.1 placenta low activity Rattus norvegicus
-
2.1.2.1 placenta activity per gram of placenta increases 2.1fold between midgestation and term Ovis aries
-
2.1.2.1 placenta low activity, activity is similar 8 weeks post conception and at term Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.2.1 L-Ser + tetrahydrofolate placental conversion of serine to glycine is a major source of fetal glycine Ovis aries Gly + 5,10-methylenetetrahydrofolate
-
 ?
2.1.2.1 additional information low activity in placenta suggests that placental conversion of serine to glycine is not a major source of fetal glycine Homo sapiens ?
-
 ?
2.1.2.1 additional information low activity in placenta suggests that placental conversion of serine to glycine is not a major source of fetal glycine Rattus norvegicus ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.1.2.1 SHMT
-
 Homo sapiens
2.1.2.1 SHMT
-
 Rattus norvegicus
2.1.2.1 SHMT
-
 Ovis aries