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Literature summary extracted from

  • Segraves, E.N.; Shah, R.R.; Segraves, N.L.; Johnson, T.A.; Whitman, S.; Sui, J.K.; Kenyon, V.A.; Cichewicz, R.H.; Crews, P.; Holman, T.R.
    Probing the activity differences of simple and complex brominated aryl compounds against 15-soybean, 15-human, and 12-human lipoxygenase (2004), J. Med. Chem., 47, 4060-4065.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.13.11.31 2,3,4,5-tetrabromo-6-(2,4-dibromophenoxy)phenol IC50: 0.0007 mM Homo sapiens
1.13.11.31 2,3,4,5-tetrabromo-6-(4,5-dibromo-2-hydroxyphenoxy)phenol IC50: 0.0041 mM Homo sapiens
1.13.11.31 2,3,5-tribromo-6-(4,5-dibromo-2-hydroxyphenoxy)phenol IC50: 0.00041 mM Homo sapiens
1.13.11.31 2,4-dibromo-6-(2,4-dibromo-6-methoxyphenoxy)phenol IC50: 0.012 mM Homo sapiens
1.13.11.31 2,6-dibromo-4-[1-(3-bromo-4-hydroxyphenyl)-1-methylethyl]phenol IC50: 0.007 mM Homo sapiens
1.13.11.31 3,4,6,8-tetrabromooxanthren-1-ol IC50: 0.05 mM Homo sapiens
1.13.11.31 3,4,6-tribromo-2-(2,4-dibromophenoxy)phenol IC50: 0.006 mM Homo sapiens
1.13.11.31 3,4-dibromo-2-(5-bromo-2-hydroxyphenoxy)phenol IC50: 0.047 mM Homo sapiens
1.13.11.31 3,6,8-tribromooxanthren-1-ol IC50: 0.03 mM Homo sapiens
1.13.11.31 3-[3-bromo-5-(2,6-dibromo-4-{2-[2-(3-bromo-4-hydroxy-phenyl)-ethylcarbamoyl]-2-[(E)-hydroxyimino]-ethyl}-phenoxy)-4-methyl-phenyl]-N-[(E)-2-(3,5-dibromo-4-hydroxy-phenyl)-vinyl]-2-[(E)-hydroxyimino]-propionamide IC50: 0.0004 mM Homo sapiens
1.13.11.31 4,4'-propane-2,2-diylbis(2,6-dibromophenol) IC50: 0.01 mM Homo sapiens
1.13.11.31 bestatin 7 IC50: 0.0023 mM Homo sapiens
1.13.11.31 nordihydroguaiaretic acid IC50: 0.0051 mM Homo sapiens
1.13.11.33 2,3,4,5-tetrabromo-6-(2,4-dibromophenoxy)phenol IC50: 0.007 mM Glycine max
1.13.11.33 2,3,4,5-tetrabromo-6-(2,4-dibromophenoxy)phenol IC50: 0.0018 mM Homo sapiens
1.13.11.33 2,3,4,5-tetrabromo-6-(3,5-dibromo-2-hydroxyphenoxy)phenol IC50: 0.00079 mM Homo sapiens
1.13.11.33 2,3,5-tribromo-6-(3,5-dibromo-2-hydroxyphenoxy)phenol IC50: 0.0022 mM Homo sapiens
1.13.11.33 2,4-dibromo-6-(2,4-dibromo-6-methoxyphenoxy)phenol IC50: 0.01 mM Homo sapiens
1.13.11.33 2,4-Dibromophenol IC50: 0.034 mM Homo sapiens
1.13.11.33 2,6-dibromo-4-[1-(3-bromo-4-hydroxyphenyl)-1-methylethyl]phenol IC50: 0.005 mM Homo sapiens
1.13.11.33 3,4,6,8-tetrabromooxanthren-1-ol IC50: 0.0009 mM Homo sapiens
1.13.11.33 3,4,6-tribromo-2-(2,4-dibromophenoxy)phenol IC50: 0.009 mM Glycine max
1.13.11.33 3,4,6-tribromo-2-(2,4-dibromophenoxy)phenol IC50: 0.005 mM Homo sapiens
1.13.11.33 3,4-dibromo-2-(5-bromo-2-hydroxyphenoxy)phenol IC50: 0.011 mM Homo sapiens
1.13.11.33 3,6,8-tribromooxanthren-1-ol IC50: 0.0008 mM Homo sapiens
1.13.11.33 3-[3-bromo-5-(2,6-dibromo-4-{2-[2-(3-bromo-4-hydroxy-phenyl)-ethylcarbamoyl]-2-[(E)-hydroxyimino]-ethyl}-phenoxy)-4-methyl-phenyl]-N-[(E)-2-(3,5-dibromo-4-hydroxy-phenyl)-vinyl]-2-[(E)-hydroxyimino]-propionamide IC50: 0.059 mM Glycine max
1.13.11.33 3-[3-bromo-5-(2,6-dibromo-4-{2-[2-(3-bromo-4-hydroxy-phenyl)-ethylcarbamoyl]-2-[(E)-hydroxyimino]-ethyl}-phenoxy)-4-methyl-phenyl]-N-[(E)-2-(3,5-dibromo-4-hydroxy-phenyl)-vinyl]-2-[(E)-hydroxyimino]-propionamide IC50: 0.059 mM Homo sapiens
1.13.11.33 4,4'-propane-2,2-diylbis(2,6-dibromophenol) IC50: 0.004 mM Homo sapiens
1.13.11.33 4-Bromophenol IC50: 0.048 mM Glycine max
1.13.11.33 4-Bromophenol IC50: 0.055 mM Homo sapiens
1.13.11.33 bestatin IC50: 0.027 mM Glycine max
1.13.11.33 bestatin 7 IC50: 0.027 mM Homo sapiens
1.13.11.33 additional information IC50 above 0.1 mM: compound 1a, compound 1b, compound 1d, compound 1e, compound 1g Homo sapiens
1.13.11.33 nordihydroguaiaretic acid IC50: 0.0018 mM Glycine max
1.13.11.33 nordihydroguaiaretic acid IC50: 0.00011 mM Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.13.11.31 Homo sapiens
-
-
-
1.13.11.33 Glycine max
-
-
-
1.13.11.33 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.13.11.31 blood platelet
-
 Homo sapiens
-
1.13.11.33 reticulocyte
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.13.11.31 arachidonate + O2
-
 Homo sapiens (5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyicosa-5,8,10,14-tetraenoate
-
 ?
1.13.11.33 linoleic acid + O2
-
 Homo sapiens 13-hydroperoxy-(9Z,11E)-linoleic acid
-
 ?
1.13.11.33 linoleic acid + O2
-
 Glycine max 13-hydroperoxy-(9Z,11E)-linoleic acid
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.13.11.31 12-hLO
-
 Homo sapiens
1.13.11.31 12-LO
-
 Homo sapiens
1.13.11.33 15-hLO
-
 Homo sapiens
1.13.11.33 15-LO
-
 Homo sapiens
1.13.11.33 15-LO
-
 Glycine max
1.13.11.33 15-sLO
-
 Glycine max

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.13.11.31 0.0004
-
 IC50: 0.0004 mM Homo sapiens 3-[3-bromo-5-(2,6-dibromo-4-{2-[2-(3-bromo-4-hydroxy-phenyl)-ethylcarbamoyl]-2-[(E)-hydroxyimino]-ethyl}-phenoxy)-4-methyl-phenyl]-N-[(E)-2-(3,5-dibromo-4-hydroxy-phenyl)-vinyl]-2-[(E)-hydroxyimino]-propionamide
1.13.11.31 0.00041
-
 IC50: 0.00041 mM Homo sapiens 2,3,5-tribromo-6-(4,5-dibromo-2-hydroxyphenoxy)phenol
1.13.11.31 0.0007
-
 IC50: 0.0007 mM Homo sapiens 2,3,4,5-tetrabromo-6-(2,4-dibromophenoxy)phenol
1.13.11.31 0.0023
-
 IC50: 0.0023 mM Homo sapiens bestatin 7
1.13.11.31 0.0041
-
 IC50: 0.0041 mM Homo sapiens 2,3,4,5-tetrabromo-6-(4,5-dibromo-2-hydroxyphenoxy)phenol
1.13.11.31 0.0051
-
 IC50: 0.0051 mM Homo sapiens nordihydroguaiaretic acid
1.13.11.31 0.006
-
 IC50: 0.006 mM Homo sapiens 3,4,6-tribromo-2-(2,4-dibromophenoxy)phenol
1.13.11.31 0.007
-
 IC50: 0.007 mM Homo sapiens 2,6-dibromo-4-[1-(3-bromo-4-hydroxyphenyl)-1-methylethyl]phenol
1.13.11.31 0.01
-
 IC50: 0.01 mM Homo sapiens 4,4'-propane-2,2-diylbis(2,6-dibromophenol)
1.13.11.31 0.012
-
 IC50: 0.012 mM Homo sapiens 2,4-dibromo-6-(2,4-dibromo-6-methoxyphenoxy)phenol
1.13.11.31 0.03
-
 IC50: 0.03 mM Homo sapiens 3,6,8-tribromooxanthren-1-ol
1.13.11.31 0.047
-
 IC50: 0.047 mM Homo sapiens 3,4-dibromo-2-(5-bromo-2-hydroxyphenoxy)phenol
1.13.11.31 0.05
-
 IC50: 0.05 mM Homo sapiens 3,4,6,8-tetrabromooxanthren-1-ol
1.13.11.33 0.00011
-
 IC50: 0.00011 mM Homo sapiens nordihydroguaiaretic acid
1.13.11.33 0.00079
-
 IC50: 0.00079 mM Homo sapiens 2,3,4,5-tetrabromo-6-(3,5-dibromo-2-hydroxyphenoxy)phenol
1.13.11.33 0.0008
-
 IC50: 0.0008 mM Homo sapiens 3,6,8-tribromooxanthren-1-ol
1.13.11.33 0.0009
-
 IC50: 0.0009 mM Homo sapiens 3,4,6,8-tetrabromooxanthren-1-ol
1.13.11.33 0.0018
-
 IC50: 0.0018 mM Glycine max nordihydroguaiaretic acid
1.13.11.33 0.0018
-
 IC50: 0.0018 mM Homo sapiens 2,3,4,5-tetrabromo-6-(2,4-dibromophenoxy)phenol
1.13.11.33 0.0022
-
 IC50: 0.0022 mM Homo sapiens 2,3,5-tribromo-6-(3,5-dibromo-2-hydroxyphenoxy)phenol
1.13.11.33 0.004
-
 IC50: 0.004 mM Homo sapiens 4,4'-propane-2,2-diylbis(2,6-dibromophenol)
1.13.11.33 0.005
-
 IC50: 0.005 mM Homo sapiens 3,4,6-tribromo-2-(2,4-dibromophenoxy)phenol
1.13.11.33 0.005
-
 IC50: 0.005 mM Homo sapiens 2,6-dibromo-4-[1-(3-bromo-4-hydroxyphenyl)-1-methylethyl]phenol
1.13.11.33 0.007
-
 IC50: 0.007 mM Glycine max 2,3,4,5-tetrabromo-6-(2,4-dibromophenoxy)phenol
1.13.11.33 0.009
-
 IC50: 0.009 mM Glycine max 3,4,6-tribromo-2-(2,4-dibromophenoxy)phenol
1.13.11.33 0.01
-
 IC50: 0.01 mM Homo sapiens 2,4-dibromo-6-(2,4-dibromo-6-methoxyphenoxy)phenol
1.13.11.33 0.011
-
 IC50: 0.011 mM Homo sapiens 3,4-dibromo-2-(5-bromo-2-hydroxyphenoxy)phenol
1.13.11.33 0.027
-
 IC50: 0.027 mM Glycine max bestatin
1.13.11.33 0.027
-
 IC50: 0.027 mM Homo sapiens bestatin 7
1.13.11.33 0.034
-
 IC50: 0.034 mM Homo sapiens 2,4-Dibromophenol
1.13.11.33 0.048
-
 IC50: 0.048 mM Glycine max 4-Bromophenol
1.13.11.33 0.055
-
 IC50: 0.055 mM Homo sapiens 4-Bromophenol
1.13.11.33 0.059
-
 IC50: 0.059 mM Homo sapiens 3-[3-bromo-5-(2,6-dibromo-4-{2-[2-(3-bromo-4-hydroxy-phenyl)-ethylcarbamoyl]-2-[(E)-hydroxyimino]-ethyl}-phenoxy)-4-methyl-phenyl]-N-[(E)-2-(3,5-dibromo-4-hydroxy-phenyl)-vinyl]-2-[(E)-hydroxyimino]-propionamide
1.13.11.33 0.059
-
 IC50: 0.059 mM Glycine max 3-[3-bromo-5-(2,6-dibromo-4-{2-[2-(3-bromo-4-hydroxy-phenyl)-ethylcarbamoyl]-2-[(E)-hydroxyimino]-ethyl}-phenoxy)-4-methyl-phenyl]-N-[(E)-2-(3,5-dibromo-4-hydroxy-phenyl)-vinyl]-2-[(E)-hydroxyimino]-propionamide
1.13.11.33 0.1
-
 IC50 above 0.1 mM: compound 1a, compound 1b, compound 1d, compound 1e, compound 1g Homo sapiens additional information