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Literature summary extracted from

  • Agrawal, S.; Kumar, A.; Srivastava, V.; Mishra, B.N.
    Cloning, expression, activity and folding studies of serine hydroxymethyltransferase: a target enzyme for cancer chemotherapy (2003), J. Mol. Microbiol. Biotechnol., 6, 67-75.
    View publication on PubMed

Application

EC Number Application Comment Organism
2.1.2.1 medicine enzyme is a target for antibiotics Escherichia coli
2.1.2.1 medicine the cytosolic SHMT is a target enzyme for chemotherapy Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.1.2.1
-
 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.1.2.1 cytosol
-
 Homo sapiens 5829
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.2.1 additional information Homo sapiens the enzyme plays an indispensable role in nucleic acid biosynthesis ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.1.2.1 Escherichia coli
-
-
-
2.1.2.1 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.1.2.1
-
 Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.2.1 L-Ser + tetrahydrofolate
-
 Escherichia coli Gly + 5,10-methylenetetrahydrofolate
-
 r
2.1.2.1 L-Ser + tetrahydrofolate
-
 Homo sapiens Gly + 5,10-methylenetetrahydrofolate
-
 r
2.1.2.1 additional information the enzyme plays an indispensable role in nucleic acid biosynthesis Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.1.2.1 eSHMT
-
 Escherichia coli
2.1.2.1 hSHMT
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
2.1.2.1 pyridoxal 5'-phosphate
-
 Escherichia coli
2.1.2.1 pyridoxal 5'-phosphate
-
 Homo sapiens