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Literature summary extracted from

  • Lamas-Maceiras, M.; Vaca, I.; Rodriguez, E.; Casqueiro, J.; Martin, J.F.
    Amplification and disruption of the phenylacetyl-CoA ligase gene of Penicillium chrysogenum encoding an aryl-capping enzyme that supplies phenylacetic acid to the isopenicillin N acyltransferase (2005), Biochem. J., 395, 147-155.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
6.2.1.30
-
 Penicillium chrysogenum

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.1.164 peroxisome colocalization of isopenicillin N-acyltransferase and phenylacetyl-CoA ligase Penicillium chrysogenum 5777
-
6.2.1.30 peroxisome it is proposed that phenylacetate-CoA ligase and isopenicillin N-acyltransferase form a peroxisomal functional complex Penicillium chrysogenum 5777
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.2.1.30 ATP + phenylacetate + CoA Penicillium chrysogenum phenylacetate-CoA ligase is involved in penicillin production. The enzyme lacks a peptidyl carrier and behaves as an aryl-capping enzyme that activates phenylacetic acid and transfers it to the isopenicillin N acyltransferase. It is proposed that phenylacetate-CoA ligase and isopenicillin N-acyltransferase form a peroxisomal functional complex AMP + diphosphate + phenylacetyl-CoA
-
 ?
6.2.1.30 ATP + phenylacetate + CoA Penicillium chrysogenum the phenylacetyl-CoA ligase encoded by the phl gene is involved in penicillin production. The Phl protein lacks a peptide-carrier-protein domain and behaves as an aryl-capping enzyme that activates phenylacetic acid and transfers it to the isopenicillin N acyltransferase AMP + diphosphate + phenylacetyl-CoA
-
 ?
6.2.1.30 ATP + phenylacetate + CoA Penicillium chrysogenum AS-P-78 phenylacetate-CoA ligase is involved in penicillin production. The enzyme lacks a peptidyl carrier and behaves as an aryl-capping enzyme that activates phenylacetic acid and transfers it to the isopenicillin N acyltransferase. It is proposed that phenylacetate-CoA ligase and isopenicillin N-acyltransferase form a peroxisomal functional complex AMP + diphosphate + phenylacetyl-CoA
-
 ?
6.2.1.30 ATP + phenylacetate + CoA Penicillium chrysogenum AS-P-78 the phenylacetyl-CoA ligase encoded by the phl gene is involved in penicillin production. The Phl protein lacks a peptide-carrier-protein domain and behaves as an aryl-capping enzyme that activates phenylacetic acid and transfers it to the isopenicillin N acyltransferase AMP + diphosphate + phenylacetyl-CoA
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.164 Penicillium chrysogenum
-
-
-
6.2.1.30 Penicillium chrysogenum
-
-
-
6.2.1.30 Penicillium chrysogenum AS-P-78
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.2.1.30 ATP + phenylacetate + CoA
-
 Penicillium chrysogenum AMP + diphosphate + phenylacetyl-CoA
-
 ?
6.2.1.30 ATP + phenylacetate + CoA phenylacetate-CoA ligase is involved in penicillin production. The enzyme lacks a peptidyl carrier and behaves as an aryl-capping enzyme that activates phenylacetic acid and transfers it to the isopenicillin N acyltransferase. It is proposed that phenylacetate-CoA ligase and isopenicillin N-acyltransferase form a peroxisomal functional complex Penicillium chrysogenum AMP + diphosphate + phenylacetyl-CoA
-
 ?
6.2.1.30 ATP + phenylacetate + CoA the phenylacetyl-CoA ligase encoded by the phl gene is involved in penicillin production. The Phl protein lacks a peptide-carrier-protein domain and behaves as an aryl-capping enzyme that activates phenylacetic acid and transfers it to the isopenicillin N acyltransferase Penicillium chrysogenum AMP + diphosphate + phenylacetyl-CoA
-
 ?
6.2.1.30 ATP + phenylacetate + CoA
-
 Penicillium chrysogenum AS-P-78 AMP + diphosphate + phenylacetyl-CoA
-
 ?
6.2.1.30 ATP + phenylacetate + CoA phenylacetate-CoA ligase is involved in penicillin production. The enzyme lacks a peptidyl carrier and behaves as an aryl-capping enzyme that activates phenylacetic acid and transfers it to the isopenicillin N acyltransferase. It is proposed that phenylacetate-CoA ligase and isopenicillin N-acyltransferase form a peroxisomal functional complex Penicillium chrysogenum AS-P-78 AMP + diphosphate + phenylacetyl-CoA
-
 ?
6.2.1.30 ATP + phenylacetate + CoA the phenylacetyl-CoA ligase encoded by the phl gene is involved in penicillin production. The Phl protein lacks a peptide-carrier-protein domain and behaves as an aryl-capping enzyme that activates phenylacetic acid and transfers it to the isopenicillin N acyltransferase Penicillium chrysogenum AS-P-78 AMP + diphosphate + phenylacetyl-CoA
-
 ?

Subunits

EC Number Subunits Comment Organism
2.3.1.164 More isopenicillin N-acyltransferase and phenylacetyl-CoA ligase which supplies phenylacetic acid to the N-acyltransferase form a peroxisomal functional complex Penicillium chrysogenum

Synonyms

EC Number Synonyms Comment Organism
6.2.1.30 Phl protein
-
 Penicillium chrysogenum