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Literature summary extracted from

  • Burke, J.R.
    Targeting IkB kinase for the treatment of inflammatory and other disorders (2003), Curr. Opin. Drug Discov. Devel., 6, 720-728.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.11.10 NEMO
-
 Homo sapiens

Application

EC Number Application Comment Organism
2.7.11.10 pharmacology IKK is a target for development of therapeutics for treatment of diseases resulting from nuclear transcription factor NFkappaB pathogenesis Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.11.10 5-Aminosalicylate weak inhibition of IKK-2 Homo sapiens
2.7.11.10 Acetylsalicylate weak inhibition of IKK-2 Homo sapiens
2.7.11.10 BMS-345541 specific for IKK-2, binds at an allosteric site Homo sapiens
2.7.11.10 curcumin weak inhibition of IKK-2 Homo sapiens
2.7.11.10 cyclopentone prostaglandines inhibition of IKK-2 Homo sapiens
2.7.11.10 salicylate weak inhibition of IKK-2 Homo sapiens
2.7.11.10 sulfasalazine weak inhibition of IKK-2 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.11.10 cytoplasm
-
 Homo sapiens 5737
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.11.10 Mg2+
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.10 ATP + [IkappaB protein] Homo sapiens signalling step of IKK bound to NFkappaB for subsequent ubiquitination of IkappaB and proteolytic degradation ADP + [IkappaB phosphoprotein]
-
 ?
2.7.11.10 additional information Homo sapiens activation of heterodimeric nuclear transcription factor NFkappaB is an essential step in inflammation, e.g. resulting in osteoarthritis, ulcerative colitis, asthma, and Crohn's disease, signalling step for phosphorylation, subsequent ubiquitination and proteolytic degradation of IkappaB, NFkappaB remains free after the reaction and is translocated to the nucleus, NFkappaB activation is also involved in development of diseases like cancer, gut ischemia-reperfusion, diabetes, or in transplant rejections, overview ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.10 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.10 ATP + [IkappaB protein]
-
 Homo sapiens ADP + [IkappaB phosphoprotein]
-
 ?
2.7.11.10 ATP + [IkappaB protein] signalling step of IKK bound to NFkappaB for subsequent ubiquitination of IkappaB and proteolytic degradation Homo sapiens ADP + [IkappaB phosphoprotein]
-
 ?
2.7.11.10 additional information activation of heterodimeric nuclear transcription factor NFkappaB is an essential step in inflammation, e.g. resulting in osteoarthritis, ulcerative colitis, asthma, and Crohn's disease, signalling step for phosphorylation, subsequent ubiquitination and proteolytic degradation of IkappaB, NFkappaB remains free after the reaction and is translocated to the nucleus, NFkappaB activation is also involved in development of diseases like cancer, gut ischemia-reperfusion, diabetes, or in transplant rejections, overview Homo sapiens ?
-
 ?

Subunits

EC Number Subunits Comment Organism
2.7.11.10 More the IKK complex consists of 3 subunits: catalytic IKKalpha and IKKbeta, and noncatalytic NEMO/IKKgamma Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
2.7.11.10 IKK
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.11.10 ATP
-
 Homo sapiens