EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
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EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
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2.7.2.3 | ATP + 3-phospho-D-glycerate | Drosophila melanogaster | the enzyme is required for ATP generation in the terminal stage of the glycolytic pathway. Important role of PGK in synaptic transmission. Disrupted phosphoglycerate kinase in nubian mutants causes altered ATP generation in nubian animals. Brain extracts show a threefold reduction in resting ATP levels compared with controls. Disruption of ATP generation in nubian animals is accompanied by temperature-dependent defects in neuronal activity with initial seizure activity, followed by an activity-dependent loss of synaptic transmission. Nubian mutants also diaplay structural defects at the synapse, with larger varicosity size but normal varicosity number | ADP + 3-phospho-D-glyceroyl phosphate | - |
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EC Number | Organism | UniProt | Comment | Textmining |
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2.7.2.3 | Drosophila melanogaster | - |
nubian mutant | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
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2.7.2.3 | ATP + 3-phospho-D-glycerate | the enzyme is required for ATP generation in the terminal stage of the glycolytic pathway. Important role of PGK in synaptic transmission. Disrupted phosphoglycerate kinase in nubian mutants causes altered ATP generation in nubian animals. Brain extracts show a threefold reduction in resting ATP levels compared with controls. Disruption of ATP generation in nubian animals is accompanied by temperature-dependent defects in neuronal activity with initial seizure activity, followed by an activity-dependent loss of synaptic transmission. Nubian mutants also diaplay structural defects at the synapse, with larger varicosity size but normal varicosity number | Drosophila melanogaster | ADP + 3-phospho-D-glyceroyl phosphate | - |
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