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Literature summary extracted from

  • MacDougall, L.K.; Gagou, M.E.; Leevers, S.J.; Hafen, E.; Waterfield, M.D.
    Targeted expression of the class II phosphoinositide 3-kinase in Drosophila melanogaster reveals lipid kinase-dependent effects on patterning and interactions with receptor signaling pathways (2004), Mol. Cell. Biol., 24, 796-808.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.1.154 expression of class I isozyme Dp110 enhances organ size by increasing the size of cells without perturbing patterning, ectopic expression of wild-type and catalytically inactive mutant of class II isozyme PI3K_68D in different patterns during Drosophila melanogaster disk development, phenotype analysis of adult cuticle Drosophila melanogaster

Protein Variants

EC Number Protein Variants Comment Organism
2.7.1.154 additional information the catalytically inactive mutant of class II isozyme PI3K_68D can bind the Drk adaptor protein in vitro Drosophila melanogaster

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.154 ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate Drosophila melanogaster
-
 ADP + 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate
-
 ?
2.7.1.154 additional information Drosophila melanogaster the isozymes interact with and effect patterning of receptor signaling pathways, overview ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.154 Drosophila melanogaster
-
 diverse strains
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.154 cuticle
-
 Drosophila melanogaster
-
2.7.1.154 larva
-
 Drosophila melanogaster
-
2.7.1.154 additional information isozyme expression pattern and phenotype, Drk adaptor protein might be involved in localization of the isozymes, overview Drosophila melanogaster
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.154 ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
-
 Drosophila melanogaster ADP + 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate
-
 ?
2.7.1.154 additional information the isozymes interact with and effect patterning of receptor signaling pathways, overview Drosophila melanogaster ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.1.154 class I phosphoinositide 3-kinase
-
 Drosophila melanogaster
2.7.1.154 class II phosphoinositide 3-kinase
-
 Drosophila melanogaster
2.7.1.154 class III phosphoinositide 3-kinase
-
 Drosophila melanogaster
2.7.1.154 phosphoinositide 3-kinase
-
 Drosophila melanogaster
2.7.1.154 PI3K
-
 Drosophila melanogaster