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Literature summary extracted from

  • Glover, D.M.
    Polo kinase and progression through M phase in Drosophila: a perspective from the spindle poles (2005), Oncogene, 24, 230-237.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.11.21 developmental expression analysis of the highly conserved enzyme Drosophila melanogaster

Protein Variants

EC Number Protein Variants Comment Organism
2.7.11.21 additional information mutant phenotype analysis Drosophila melanogaster

General Stability

EC Number General Stability Organism
2.7.11.21 association with Hsp90 at the centrosome stabilizes the enzyme Drosophila melanogaster

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.11.21 centrosome associated with Hsp90 Drosophila melanogaster 5813
-
2.7.11.21 cytoplasm
-
 Drosophila melanogaster 5737
-
2.7.11.21 kinetochore
-
 Drosophila melanogaster 776
-
2.7.11.21 spindle mid zone of the central spindle Drosophila melanogaster 5819
-
2.7.11.21 spindle pole
-
 Drosophila melanogaster 922
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.21 ATP + 85kDa microtubule-associated protein Drosophila melanogaster protein is released from microtubules after phosphorylation ADP + phosphorylated 85kDa microtubule-associated protein
-
 ?
2.7.11.21 ATP + abnormal spindle pole protein Drosophila melanogaster i.e. abnormal spindle pole protein, activation of abnormal spindle pole protein by phosphorylation ADP + phosphorylated abnormal spindle pole protein
-
 ?
2.7.11.21 ATP + dephospho-beta-tubulin Drosophila melanogaster the enzyme is required for beta-tubulin recruitment to the centrosome ADP + phosphorylated beta-tubulin
-
 ?
2.7.11.21 additional information Drosophila melanogaster the enzyme is a mitotic kinase and is required for centrosome maturation at mitotic M-phase entry in order to recruit the gamma-tubulin ring complex and activate abnormal spindle pole protein, Asp, the enzyme is involved in mitotic networks and cytokinesis, e.g. in spermatogenesis, overview, functional modeling of polo kinase in mitotic phases ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.21 Drosophila melanogaster
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.21 embryo
-
 Drosophila melanogaster
-
2.7.11.21 larva
-
 Drosophila melanogaster
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.21 ATP + 85kDa microtubule-associated protein
-
 Drosophila melanogaster ADP + phosphorylated 85kDa microtubule-associated protein
-
 ?
2.7.11.21 ATP + 85kDa microtubule-associated protein protein is released from microtubules after phosphorylation Drosophila melanogaster ADP + phosphorylated 85kDa microtubule-associated protein
-
 ?
2.7.11.21 ATP + abnormal spindle pole protein
-
 Drosophila melanogaster ADP + phosphorylated abnormal spindle pole protein
-
 ?
2.7.11.21 ATP + abnormal spindle pole protein i.e. abnormal spindle pole protein, activation of abnormal spindle pole protein by phosphorylation Drosophila melanogaster ADP + phosphorylated abnormal spindle pole protein
-
 ?
2.7.11.21 ATP + dephospho-beta-tubulin
-
 Drosophila melanogaster ADP + phosphorylated beta-tubulin
-
 ?
2.7.11.21 ATP + dephospho-beta-tubulin the enzyme is required for beta-tubulin recruitment to the centrosome Drosophila melanogaster ADP + phosphorylated beta-tubulin
-
 ?
2.7.11.21 additional information the enzyme is a mitotic kinase and is required for centrosome maturation at mitotic M-phase entry in order to recruit the gamma-tubulin ring complex and activate abnormal spindle pole protein, Asp, the enzyme is involved in mitotic networks and cytokinesis, e.g. in spermatogenesis, overview, functional modeling of polo kinase in mitotic phases Drosophila melanogaster ?
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.11.21 ATP
-
 Drosophila melanogaster