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Literature summary extracted from

  • Newman, J.W.; Morisseau, C.; Hammock, B.D.
    Epoxide hydrolases: their roles and interactions with lipid metabolism (2005), Prog. Lipid Res., 44, 1-51.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.3.2.9 additional information insulin increases enzyme activity in hepatocyte cell culture Rattus norvegicus
3.3.2.9 Phospholipids the enzyme is tightly associated with phospholipids Homo sapiens
3.3.2.10 additional information inducible isozymes can be induced by e.g. fruit ripening, germination, host-defense, exogenous exposure to hormones, growth Vicia sativa
3.3.2.10 additional information inducible isozymes can be induced by e.g. fruit ripening, germination, host-defense, exogenous exposure to hormones, growth Triticum aestivum
3.3.2.10 additional information inducible isozymes can be induced by e.g. fruit ripening, germination, host-defense, exogenous exposure to hormones, growth Spinacia oleracea
3.3.2.10 additional information inducible isozymes can be induced by e.g. fruit ripening, germination, host-defense, exogenous exposure to hormones, growth Brassica napus
3.3.2.10 additional information inducible isozymes can be induced by e.g. fruit ripening, germination, host-defense, exogenous exposure to hormones, growth Ricinus communis
3.3.2.10 additional information inducible isozymes can be induced by e.g. fruit ripening, germination, host-defense, exogenous exposure to hormones, growth Apium graveolens
3.3.2.10 additional information inducible isozymes can be induced by e.g. fruit ripening, germination, host-defense, exogenous exposure to hormones, growth Oryza sativa
3.3.2.10 additional information inducible isozymes can be induced by e.g. fruit ripening, germination, host-defense, exogenous exposure to hormones, growth Ananas comosus
3.3.2.10 additional information inducible isozymes can be induced by e.g. fruit ripening, germination, host-defense, exogenous exposure to hormones, growth Euphorbia lagascae
3.3.2.10 additional information inducible isozymes can be induced by e.g. fruit ripening, germination, host-defense, exogenous exposure to hormones, growth Malus pumila
3.3.2.10 additional information inducible isozymes can be induced by e.g. fruit ripening, germination, host-defense, exogenous exposure to hormones, growth, ethylene induces the enzyme in germinating seeds Glycine max
3.3.2.10 additional information inducible isozymes can be induced by e.g. fruit ripening, germination, host-defense, exogenous exposure to hormones, growth, pathogenic fungus infection induces the enzyme in leaves Citrus jambhiri
3.3.2.10 additional information inducible isozymes can be induced by e.g. fruit ripening, germination, host-defense, exogenous exposure to hormones, growth, viral infection of the aerial body and the plant induces the enzyme Nicotiana tabacum
3.3.2.10 additional information inducible isozymes can be induced by e.g. fruit ripening, germination, host-defense, growth, the enzyme is not affected by cytokinin, abscisic acid, 6-benzylaminopurine, or gibberellin, but highly by methyl jasmonate, auxin, and ethylene, wounding induces the enzyme in leaves Solanum tuberosum
3.3.2.10 additional information inducible isozymes can be induced by e.g. fruit ripening, germination, host-defense, growth, the enzyme is not affected by cytokinin, abscisic acid, 6-benzylaminopurine, or gibberellin, while auxin, 2,4-dichlorophenoxy acetic acid, and naphthalene acetic acid induce the enzyme in stem and leaves, drought stress slightly induces the enzmye in stem and leaves Arabidopsis thaliana
3.3.2.10 additional information the enzyme is induced by clofibrate Cavia porcellus
3.3.2.10 additional information the enzyme is induced by clofibrate Homo sapiens
3.3.2.10 additional information the enzyme is induced by clofibrate Rattus norvegicus
3.3.2.10 additional information the enzyme is induced by clofibrate Sus scrofa
3.3.2.10 additional information the enzyme is induced by clofibrate Oryctolagus cuniculus
3.3.2.10 additional information the enzyme is induced by clofibrate Mesocricetus auratus
3.3.2.10 additional information the enzyme is induced by clofibrate Equus caballus
3.3.2.10 additional information the enzyme is induced by clofibrate Macaca mulatta
3.3.2.10 additional information the enzyme is induced by clofibrate Papio sp.
3.3.2.10 additional information the enzyme is induced by clofibrate Mus musculus

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.3.2.9
-
 Rattus norvegicus
3.3.2.9 gene EPHX1 is located on chromosome 1, DNA and amino acid sequence determination and analysis, expression of liver enzyme in Schizosaccharomyces pombe, expression in Cos-1 cells, expression using the baculovirus system Homo sapiens

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
3.1.3.76 crystal structure analysis Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
3.3.2.9 E404D mutation of the catalytic triad residue leads to increased activity compared to the wild-type enzyme Homo sapiens
3.3.2.9 additional information polymorphisms associated with the onset of diseases Homo sapiens
3.3.2.10 additional information enzyme polymorphisms, overview Homo sapiens
3.3.2.10 R287E naturally occuring mutation of gene EPXH2 leads to elevated plasma cholesterol and triglycerides Homo sapiens
3.3.2.10 R287Q naturally occuring mutation of gene EPXH2 leads to elevated risk of coronary artery calcification found in African Americans Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.3.2.9 additional information suppression of enzyme expression by glucocorticoid, interacting with the 5'-flanking sequence, and by dexamethasone, gadolinium chloride, acriflavine, lipopolysaccharide, gem-di-, trans-di-, tri- and tetra-substituted epoxides are either low turnover substrates or inhibitors Homo sapiens
3.3.2.9 additional information suppression of enzyme expression by dexamethasone, gadolinium chloride, acriflavine, lipopolysaccharide Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.1.3.76 0.021
-
 threo-9-hydroxy-10-(phosphonooxy)octadecanoate pH 7.8, 37°C, recombinant enzyme Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.3.2.9 cytosol in neoplastic livers Homo sapiens 5829
-
3.3.2.9 microsome
-
 Mus musculus
-
-
3.3.2.9 microsome
-
 Homo sapiens
-
-
3.3.2.9 microsome
-
 Rattus norvegicus
-
-
3.3.2.9 additional information the enzyme shows strong hydrophobic interaction with the membrane, deletion of the N-terminal membrane anchor does not render the enzyme soluble Homo sapiens
-
-
3.3.2.9 plasma membrane in liver, the catalytic site facing the extracellular medium Homo sapiens 5886
-
3.3.2.9 smooth endoplasmic reticulum in liver, the catalytic site facing the cytosol Homo sapiens 5790
-
3.3.2.10 cytosol
-
 Vicia sativa 5829
-
3.3.2.10 cytosol
-
 Cavia porcellus 5829
-
3.3.2.10 cytosol
-
 Homo sapiens 5829
-
3.3.2.10 cytosol
-
 Rattus norvegicus 5829
-
3.3.2.10 cytosol
-
 Sus scrofa 5829
-
3.3.2.10 cytosol
-
 Triticum aestivum 5829
-
3.3.2.10 cytosol
-
 Oryctolagus cuniculus 5829
-
3.3.2.10 cytosol
-
 Spinacia oleracea 5829
-
3.3.2.10 cytosol
-
 Zea mays 5829
-
3.3.2.10 cytosol
-
 Solanum tuberosum 5829
-
3.3.2.10 cytosol
-
 Nicotiana tabacum 5829
-
3.3.2.10 cytosol
-
 Glycine max 5829
-
3.3.2.10 cytosol
-
 Arabidopsis thaliana 5829
-
3.3.2.10 cytosol
-
 Brassica napus 5829
-
3.3.2.10 cytosol
-
 Ricinus communis 5829
-
3.3.2.10 cytosol
-
 Mesocricetus auratus 5829
-
3.3.2.10 cytosol
-
 Equus caballus 5829
-
3.3.2.10 cytosol
-
 Apium graveolens 5829
-
3.3.2.10 cytosol
-
 Macaca mulatta 5829
-
3.3.2.10 cytosol
-
 Oryza sativa 5829
-
3.3.2.10 cytosol
-
 Oncorhynchus mykiss 5829
-
3.3.2.10 cytosol
-
 Ananas comosus 5829
-
3.3.2.10 cytosol
-
 Oryzias latipes 5829
-
3.3.2.10 cytosol
-
 Papio sp. 5829
-
3.3.2.10 cytosol
-
 Euphorbia lagascae 5829
-
3.3.2.10 cytosol
-
 Mus musculus 5829
-
3.3.2.10 cytosol
-
 Citrus jambhiri 5829
-
3.3.2.10 cytosol
-
 Malus pumila 5829
-
3.3.2.10 cytosol
-
 Pimephales promelas 5829
-
3.3.2.10 cytosol
-
 Stenotomus chrysops 5829
-
3.3.2.10 glyoxysome
-
 Ricinus communis 9514
-
3.3.2.10 peroxisome in the light mitochondrial fraction Mus musculus 5777
-
3.3.2.10 peroxisome the enzyme contains an impaired peroxisomal targeting sequence leading to dual localization Rattus norvegicus 5777
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.1.3.76 Mg2+ dependent on Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.3.2.9 50000
-
 x * 50000, about Homo sapiens
3.3.2.10 35000
-
 n * 35000, about Solanum tuberosum
3.3.2.10 35000
-
 n * 35000, about Glycine max
3.3.2.10 35000
-
 n * 35000, about Arabidopsis thaliana
3.3.2.10 35000
-
 n * 35000, about Ricinus communis
3.3.2.10 35000
-
 x * 35000, about Vicia sativa
3.3.2.10 35000
-
 x * 35000, about Triticum aestivum
3.3.2.10 35000
-
 x * 35000, about Spinacia oleracea
3.3.2.10 35000
-
 x * 35000, about Nicotiana tabacum
3.3.2.10 35000
-
 x * 35000, about Brassica napus
3.3.2.10 35000
-
 x * 35000, about Apium graveolens
3.3.2.10 35000
-
 x * 35000, about Oryza sativa
3.3.2.10 35000
-
 x * 35000, about Ananas comosus
3.3.2.10 35000
-
 x * 35000, about Euphorbia lagascae
3.3.2.10 35000
-
 x * 35000, about Citrus jambhiri
3.3.2.10 35000
-
 x * 35000, about Malus pumila
3.3.2.10 62000
-
 2 * 62000, about Cavia porcellus
3.3.2.10 62000
-
 2 * 62000, about Homo sapiens
3.3.2.10 62000
-
 2 * 62000, about Rattus norvegicus
3.3.2.10 62000
-
 2 * 62000, about Sus scrofa
3.3.2.10 62000
-
 2 * 62000, about Oryctolagus cuniculus
3.3.2.10 62000
-
 2 * 62000, about Mesocricetus auratus
3.3.2.10 62000
-
 2 * 62000, about Equus caballus
3.3.2.10 62000
-
 2 * 62000, about Macaca mulatta
3.3.2.10 62000
-
 2 * 62000, about Papio sp.
3.3.2.10 62000
-
 2 * 62000, about Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.3.2.9 additional information Homo sapiens key enzyme in the metabolism of environmental contaminants being responsible for xenobiotic transformations, regulation of the enzyme occurs at transcriptional, translational, and post-translational level, the enzyme is also involved in cytoprotection and steroid metabolism, as well as in cellular responses to glucose metabolism and in Na+-dependent bile acid transport, the enzyme is part of a multi-transport system at the cell surface ?
-
 ?
3.3.2.9 additional information Mus musculus key enzyme in the metabolism of environmental contaminants being responsible for xenobiotic transformations, regulation of the enzyme occurs at transcriptional, translational, and post-translational level. The enzyme is also involved in cytoprotection and steroid metabolism, as well as in cellular responses to glucose metabolism and in Na+-dependent bile acid transport. The enzyme is part of a multi-transport system at the cell surface ?
-
 ?
3.3.2.9 additional information Rattus norvegicus the enzyme activity in diabetic and in fasted rats is reduced by 60-71%, key enzyme in the metabolism of environmental contaminants being responsible for xenobiotic transformations, regulation of the enzyme occurs at transcriptional, translational, and post-translational level, the enzyme is also involved in cytoprotection and steroid metabolism, as well as in cellular responses to glucose metabolism and in Na+-dependent bile acid transport, the enzyme is part of a multi-transport system at the cell surface ?
-
 ?
3.3.2.10 9,10-epoxy-18-hydroxy octadeca-(12Z)-eneoic acid + H2O Solanum tuberosum
-
 ?
-
 ?
3.3.2.10 9,10-epoxy-18-hydroxy octadeca-(12Z)-eneoic acid + H2O Citrus jambhiri
-
 ?
-
 ?
3.3.2.10 9,10-epoxy-18-hydroxy octadeca-(12Z)-eneoic acid + H2O Malus pumila step in cutin biosynthesis ?
-
 ?
3.3.2.10 additional information Homo sapiens enzyme regulation, overview ?
-
 ?
3.3.2.10 additional information Oncorhynchus mykiss enzyme regulation, overview ?
-
 ?
3.3.2.10 additional information Oryzias latipes enzyme regulation, overview ?
-
 ?
3.3.2.10 additional information Pimephales promelas enzyme regulation, overview ?
-
 ?
3.3.2.10 additional information Stenotomus chrysops enzyme regulation, overview ?
-
 ?
3.3.2.10 additional information Vicia sativa preferred endogenous substrates are epoxides containing fatty acids, e.g. epoxides of stearic and linoleic acids, and hepoxilins ?
-
 ?
3.3.2.10 additional information Triticum aestivum preferred endogenous substrates are epoxides containing fatty acids, e.g. epoxides of stearic and linoleic acids, and hepoxilins ?
-
 ?
3.3.2.10 additional information Spinacia oleracea preferred endogenous substrates are epoxides containing fatty acids, e.g. epoxides of stearic and linoleic acids, and hepoxilins ?
-
 ?
3.3.2.10 additional information Zea mays preferred endogenous substrates are epoxides containing fatty acids, e.g. epoxides of stearic and linoleic acids, and hepoxilins ?
-
 ?
3.3.2.10 additional information Nicotiana tabacum preferred endogenous substrates are epoxides containing fatty acids, e.g. epoxides of stearic and linoleic acids, and hepoxilins ?
-
 ?
3.3.2.10 additional information Glycine max preferred endogenous substrates are epoxides containing fatty acids, e.g. epoxides of stearic and linoleic acids, and hepoxilins ?
-
 ?
3.3.2.10 additional information Arabidopsis thaliana preferred endogenous substrates are epoxides containing fatty acids, e.g. epoxides of stearic and linoleic acids, and hepoxilins ?
-
 ?
3.3.2.10 additional information Brassica napus preferred endogenous substrates are epoxides containing fatty acids, e.g. epoxides of stearic and linoleic acids, and hepoxilins ?
-
 ?
3.3.2.10 additional information Ricinus communis preferred endogenous substrates are epoxides containing fatty acids, e.g. epoxides of stearic and linoleic acids, and hepoxilins ?
-
 ?
3.3.2.10 additional information Apium graveolens preferred endogenous substrates are epoxides containing fatty acids, e.g. epoxides of stearic and linoleic acids, and hepoxilins ?
-
 ?
3.3.2.10 additional information Oryza sativa preferred endogenous substrates are epoxides containing fatty acids, e.g. epoxides of stearic and linoleic acids, and hepoxilins ?
-
 ?
3.3.2.10 additional information Ananas comosus preferred endogenous substrates are epoxides containing fatty acids, e.g. epoxides of stearic and linoleic acids, and hepoxilins ?
-
 ?
3.3.2.10 additional information Euphorbia lagascae preferred endogenous substrates are epoxides containing fatty acids, e.g. epoxides of stearic and linoleic acids, and hepoxilins ?
-
 ?
3.3.2.10 additional information Malus pumila synthesis of anti-fungal substances in fruits, the enzyme is involved in host-defense and cutin biosynthesis, preferred endogenous substrates are epoxides containing fatty acids, e.g. epoxides of stearic and linoleic acids, and hepoxilins ?
-
 ?
3.3.2.10 additional information Citrus jambhiri the enzyme is involved in host-defense and cutin biosynthesis, preferred endogenous substrates are epoxides containing fatty acids, e.g. epoxides of stearic and linoleic acids, and hepoxilins ?
-
 ?
3.3.2.10 additional information Solanum tuberosum the enzyme is involved in host-defense and cutin biosynthesis, synthesis of (9S,10S,11R)-trihydroxy-12(Z)-octadecenoic and (9S,12S,13S)-trihydroxy-10(E)-octadecenoic acids with potent anti-fungal properties, preferred endogenous substrates are epoxides containing fatty acids, e.g. epoxides of stearic and linoleic acids, and hepoxilins ?
-
 ?
3.3.2.10 additional information Cavia porcellus the enzyme is involved in metabolism of epoxide lipids in blood pressure, inflammation, reproduction and in lidpi/carbohydrate metabolism, enzyme regulation, overview ?
-
 ?
3.3.2.10 additional information Rattus norvegicus the enzyme is involved in metabolism of epoxide lipids in blood pressure, inflammation, reproduction and in lidpi/carbohydrate metabolism, enzyme regulation, overview ?
-
 ?
3.3.2.10 additional information Sus scrofa the enzyme is involved in metabolism of epoxide lipids in blood pressure, inflammation, reproduction and in lidpi/carbohydrate metabolism, enzyme regulation, overview ?
-
 ?
3.3.2.10 additional information Oryctolagus cuniculus the enzyme is involved in metabolism of epoxide lipids in blood pressure, inflammation, reproduction and in lidpi/carbohydrate metabolism, enzyme regulation, overview ?
-
 ?
3.3.2.10 additional information Mesocricetus auratus the enzyme is involved in metabolism of epoxide lipids in blood pressure, inflammation, reproduction and in lidpi/carbohydrate metabolism, enzyme regulation, overview ?
-
 ?
3.3.2.10 additional information Equus caballus the enzyme is involved in metabolism of epoxide lipids in blood pressure, inflammation, reproduction and in lidpi/carbohydrate metabolism, enzyme regulation, overview ?
-
 ?
3.3.2.10 additional information Macaca mulatta the enzyme is involved in metabolism of epoxide lipids in blood pressure, inflammation, reproduction and in lidpi/carbohydrate metabolism, enzyme regulation, overview ?
-
 ?
3.3.2.10 additional information Papio sp. the enzyme is involved in metabolism of epoxide lipids in blood pressure, inflammation, reproduction and in lipid/carbohydrate metabolism, enzyme regulation, overview ?
-
 ?
3.3.2.10 additional information Mus musculus the enzyme is involved in synthesis of tetrahydrofuran diol and trihydroxy furanyl lipids, enzyme regulation, overview ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.3.76 Homo sapiens
-
-
-
3.3.2.9 Homo sapiens
-
-
-
3.3.2.9 Mus musculus
-
-
-
3.3.2.9 Rattus norvegicus
-
-
-
3.3.2.10 Ananas comosus
-
 multiple isozymes, constitutive and inducible
-
3.3.2.10 Apium graveolens
-
 multiple isozymes, constitutive and inducible
-
3.3.2.10 Arabidopsis thaliana
-
 multiple isozymes, constitutive and inducible
-
3.3.2.10 Brassica napus
-
 multiple isozymes, constitutive and inducible
-
3.3.2.10 Cavia porcellus
-
-
-
3.3.2.10 Citrus jambhiri
-
 multiple isozymes, constitutive and inducible
-
3.3.2.10 Equus caballus
-
-
-
3.3.2.10 Euphorbia lagascae
-
 multiple isozymes, constitutive and inducible
-
3.3.2.10 Glycine max
-
 multiple isozymes, constitutive and inducible
-
3.3.2.10 Homo sapiens
-
-
-
3.3.2.10 Macaca mulatta
-
-
-
3.3.2.10 Malus pumila
-
 multiple isozymes, constitutive and inducible
-
3.3.2.10 Mesocricetus auratus
-
-
-
3.3.2.10 Mus musculus P34914 isozyme EPXH2B
-
3.3.2.10 Nicotiana tabacum
-
 multiple isozymes, constitutive and infection-induced
-
3.3.2.10 Oncorhynchus mykiss
-
-
-
3.3.2.10 Oryctolagus cuniculus
-
-
-
3.3.2.10 Oryza sativa
-
 multiple isozymes, constitutive and inducible
-
3.3.2.10 Oryzias latipes
-
-
-
3.3.2.10 Papio sp.
-
 baboon
-
3.3.2.10 Pimephales promelas
-
-
-
3.3.2.10 Rattus norvegicus
-
-
-
3.3.2.10 Ricinus communis
-
 multiple isozymes, constitutive and inducible
-
3.3.2.10 Solanum tuberosum
-
 multiple isozymes, constitutive and inducible
-
3.3.2.10 Spinacia oleracea
-
 multiple isozymes, constitutive and inducible
-
3.3.2.10 Stenotomus chrysops
-
-
-
3.3.2.10 Sus scrofa
-
-
-
3.3.2.10 Triticum aestivum
-
 multiple isozymes, constitutive and inducible
-
3.3.2.10 Vicia sativa
-
 multiple isozymes, constitutive and inducible
-
3.3.2.10 Zea mays
-
 multiple isozymes
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.3.2.10 from liver Cavia porcellus
3.3.2.10 from liver Mus musculus

Reaction

EC Number Reaction Comment Organism Reaction ID
3.1.3.76 (9S,10S)-10-hydroxy-9-(phosphooxy)octadecanoate + H2O = (9S,10S)-9,10-dihydroxyoctadecanoate + phosphate the phosphatase activity of the enzyme is located at the N-terminal part, the C-terminal part harbors the epoxide hydrolase activity of EC 3.3.2.10, both catalytic sites act independently Homo sapiens
a

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.3.2.9 adrenal gland
-
 Homo sapiens
-
3.3.2.9 adrenal gland adrenalectomy elevates enzyme levels Rattus norvegicus
-
3.3.2.9 brain
-
 Mus musculus
-
3.3.2.9 brain
-
 Homo sapiens
-
3.3.2.9 brain
-
 Rattus norvegicus
-
3.3.2.9 bronchus
-
 Homo sapiens
-
3.3.2.9 cell culture numerous cancer cell lines and primary cells Homo sapiens
-
3.3.2.9 epithelium bronchial Homo sapiens
-
3.3.2.9 glial cell high enzyme content Mus musculus
-
3.3.2.9 glial cell high enzyme content Homo sapiens
-
3.3.2.9 glial cell high enzyme content Rattus norvegicus
-
3.3.2.9 heart
-
 Mus musculus
-
3.3.2.9 heart
-
 Rattus norvegicus
-
3.3.2.9 hepatocyte
-
 Rattus norvegicus
-
3.3.2.9 hypothalamus
-
 Rattus norvegicus
-
3.3.2.9 liver
-
 Mus musculus
-
3.3.2.9 liver
-
 Homo sapiens
-
3.3.2.9 liver the liver enzyme is controlled by the pituitary gland Rattus norvegicus
-
3.3.2.9 lung
-
 Mus musculus
-
3.3.2.9 lung
-
 Homo sapiens
-
3.3.2.9 lung
-
 Rattus norvegicus
-
3.3.2.9 lymphocyte
-
 Homo sapiens
-
3.3.2.9 lymphocyte intra-epithelial, cells show down-regulated enzyme expression Mus musculus
-
3.3.2.9 monocyte
-
 Homo sapiens
-
3.3.2.9 additional information wide tissue distribution in mammalian tissue, enzyme levels vary with environmental exposure, sex, and age Mus musculus
-
3.3.2.9 additional information wide tissue distribution in mammalian tissue, enzyme levels vary with environmental exposure, sex, and age Homo sapiens
-
3.3.2.9 additional information wide tissue distribution in mammalian tissue, enzyme levels vary with environmental exposure, sex, and age, growth hormones are involved in sexually dimorphic liver enzyme expression Rattus norvegicus
-
3.3.2.9 neuron low enzyme content Mus musculus
-
3.3.2.9 neuron low enzyme content Homo sapiens
-
3.3.2.9 neuron low enzyme content Rattus norvegicus
-
3.3.2.9 ovary
-
 Mus musculus
-
3.3.2.9 pituitary gland hypophysectomy induces the liver enzyme in females and males Rattus norvegicus
-
3.3.2.9 synovial tissue
-
 Homo sapiens
-
3.3.2.9 testis
-
 Mus musculus
-
3.3.2.9 testis
-
 Rattus norvegicus
-
3.3.2.10 adrenal gland
-
 Homo sapiens
-
3.3.2.10 aerial part
-
 Nicotiana tabacum
-
3.3.2.10 brain
-
 Rattus norvegicus
-
3.3.2.10 endosperm
-
 Ricinus communis
-
3.3.2.10 endothelium vascular Homo sapiens
-
3.3.2.10 epididymis
-
 Homo sapiens
-
3.3.2.10 fruit
-
 Malus pumila
-
3.3.2.10 gonad
-
 Homo sapiens
-
3.3.2.10 heart
-
 Rattus norvegicus
-
3.3.2.10 intestine
-
 Homo sapiens
-
3.3.2.10 kidney cortex Homo sapiens
-
3.3.2.10 kidney cortex Rattus norvegicus
-
3.3.2.10 kidney cortex Mus musculus
-
3.3.2.10 leaf
-
 Nicotiana tabacum
-
3.3.2.10 leaf
-
 Arabidopsis thaliana
-
3.3.2.10 leaf
-
 Citrus jambhiri
-
3.3.2.10 leaf meristem shows increased enzyme level compared to expanding and mature leaves Solanum tuberosum
-
3.3.2.10 leukocyte
-
 Rattus norvegicus
-
3.3.2.10 liver
-
 Cavia porcellus
-
3.3.2.10 liver
-
 Homo sapiens
-
3.3.2.10 liver
-
 Rattus norvegicus
-
3.3.2.10 liver
-
 Mus musculus
-
3.3.2.10 lung
-
 Rattus norvegicus
-
3.3.2.10 lymph node
-
 Homo sapiens
-
3.3.2.10 mammary gland
-
 Mus musculus
-
3.3.2.10 additional information tissue distribution Vicia sativa
-
3.3.2.10 additional information tissue distribution Cavia porcellus
-
3.3.2.10 additional information tissue distribution Homo sapiens
-
3.3.2.10 additional information tissue distribution Rattus norvegicus
-
3.3.2.10 additional information tissue distribution Sus scrofa
-
3.3.2.10 additional information tissue distribution Triticum aestivum
-
3.3.2.10 additional information tissue distribution Oryctolagus cuniculus
-
3.3.2.10 additional information tissue distribution Spinacia oleracea
-
3.3.2.10 additional information tissue distribution Zea mays
-
3.3.2.10 additional information tissue distribution Solanum tuberosum
-
3.3.2.10 additional information tissue distribution Nicotiana tabacum
-
3.3.2.10 additional information tissue distribution Glycine max
-
3.3.2.10 additional information tissue distribution Arabidopsis thaliana
-
3.3.2.10 additional information tissue distribution Brassica napus
-
3.3.2.10 additional information tissue distribution Ricinus communis
-
3.3.2.10 additional information tissue distribution Mesocricetus auratus
-
3.3.2.10 additional information tissue distribution Equus caballus
-
3.3.2.10 additional information tissue distribution Apium graveolens
-
3.3.2.10 additional information tissue distribution Macaca mulatta
-
3.3.2.10 additional information tissue distribution Oryza sativa
-
3.3.2.10 additional information tissue distribution Oncorhynchus mykiss
-
3.3.2.10 additional information tissue distribution Ananas comosus
-
3.3.2.10 additional information tissue distribution Oryzias latipes
-
3.3.2.10 additional information tissue distribution Papio sp.
-
3.3.2.10 additional information tissue distribution Euphorbia lagascae
-
3.3.2.10 additional information tissue distribution Mus musculus
-
3.3.2.10 additional information tissue distribution Citrus jambhiri
-
3.3.2.10 additional information tissue distribution Malus pumila
-
3.3.2.10 additional information tissue distribution Pimephales promelas
-
3.3.2.10 additional information tissue distribution Stenotomus chrysops
-
3.3.2.10 muscle striated Mus musculus
-
3.3.2.10 ovary
-
 Homo sapiens
-
3.3.2.10 ovary
-
 Mus musculus
-
3.3.2.10 pancreas
-
 Homo sapiens
-
3.3.2.10 placenta
-
 Homo sapiens
-
3.3.2.10 prostate
-
 Homo sapiens
-
3.3.2.10 seed germinating Glycine max
-
3.3.2.10 seed germination-specific isozyme Euphorbia lagascae
-
3.3.2.10 skin
-
 Rattus norvegicus
-
3.3.2.10 smooth muscle
-
 Homo sapiens
-
3.3.2.10 spleen
-
 Rattus norvegicus
-
3.3.2.10 stem
-
 Arabidopsis thaliana
-
3.3.2.10 stomach
-
 Homo sapiens
-
3.3.2.10 testis
-
 Rattus norvegicus
-
3.3.2.10 tonsil
-
 Homo sapiens
-
3.3.2.10 urinary bladder
-
 Homo sapiens
-
3.3.2.10 uterus
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.3.76 erythro-9-hydroxy-10-(phosphonooxy)octadecanoate + H2O
-
 Homo sapiens erythro-9,10-dihydroxyoctadecanoic acid + phosphate i.e. dihydroxy elaidic acid ?
3.1.3.76 additional information the enzyme acts regioselectively, substrate specificity Homo sapiens ?
-
 ?
3.1.3.76 threo-9-hydroxy-10-(phosphonooxy)octadecanoate + H2O preferred substrate Homo sapiens threo-9,10-dihydroxyoctadecanoic acid + phosphate i.e. dihydroxy stearic acid ?
3.3.2.9 epoxy-stearic acid + H2O highly enantiospecific reaction, low activity Homo sapiens ?
-
 ?
3.3.2.9 additional information key enzyme in the metabolism of environmental contaminants being responsible for xenobiotic transformations, regulation of the enzyme occurs at transcriptional, translational, and post-translational level, the enzyme is also involved in cytoprotection and steroid metabolism, as well as in cellular responses to glucose metabolism and in Na+-dependent bile acid transport, the enzyme is part of a multi-transport system at the cell surface Homo sapiens ?
-
 ?
3.3.2.9 additional information key enzyme in the metabolism of environmental contaminants being responsible for xenobiotic transformations, regulation of the enzyme occurs at transcriptional, translational, and post-translational level. The enzyme is also involved in cytoprotection and steroid metabolism, as well as in cellular responses to glucose metabolism and in Na+-dependent bile acid transport. The enzyme is part of a multi-transport system at the cell surface Mus musculus ?
-
 ?
3.3.2.9 additional information the enzyme activity in diabetic and in fasted rats is reduced by 60-71%, key enzyme in the metabolism of environmental contaminants being responsible for xenobiotic transformations, regulation of the enzyme occurs at transcriptional, translational, and post-translational level, the enzyme is also involved in cytoprotection and steroid metabolism, as well as in cellular responses to glucose metabolism and in Na+-dependent bile acid transport, the enzyme is part of a multi-transport system at the cell surface Rattus norvegicus ?
-
 ?
3.3.2.9 additional information wide substrate specificity, epoxide-containing glycerol-phospholipids are poor substrates, the enzyme prefers mono- and cis-1,2-disubstituted epoxides as substrates, while gem-di-, trans-di-, tri- and tetra-substituted epoxides are either low turnover substrates or inhibitors, the enzyme has a tamaoxifen binding site Homo sapiens ?
-
 ?
3.3.2.9 additional information wide substrate specificity, the enzyme prefers mono- and cis-1,2-disubstituted epoxides as substrates, while gem-di-, trans-di-, tri- and tetra-substituted epoxides are either low turnover substrates or inhibitors Mus musculus ?
-
 ?
3.3.2.9 additional information wide substrate specificity, the enzyme prefers mono- and cis-1,2-disubstituted epoxides as substrates, while gem-di-, trans-di-, tri- and tetra-substituted epoxides are either low turnover substrates or inhibitors Rattus norvegicus ?
-
 ?
3.3.2.10 11,12-leukotriene A4 + H2O
-
 Cavia porcellus ?
-
 ?
3.3.2.10 11R,12S-epoxyeicosatrienoic acid + H2O
-
 Mus musculus 11R,12S-dihydroxyeicosatrienoic acid
-
 ?
3.3.2.10 11S,12R-epoxyeicosatrienoic acid + H2O
-
 Mus musculus 11S,12R-hydroxyeicosatrienoic acid
-
 ?
3.3.2.10 12,13-epoxy octadeca-(9Z)-eneoic acid + H2O
-
 Vicia sativa ?
-
 ?
3.3.2.10 12,13-epoxy octadeca-(9Z)-eneoic acid + H2O
-
 Triticum aestivum ?
-
 ?
3.3.2.10 12,13-epoxy octadeca-(9Z)-eneoic acid + H2O
-
 Spinacia oleracea ?
-
 ?
3.3.2.10 12,13-epoxy octadeca-(9Z)-eneoic acid + H2O
-
 Zea mays ?
-
 ?
3.3.2.10 12,13-epoxy octadeca-(9Z)-eneoic acid + H2O
-
 Solanum tuberosum ?
-
 ?
3.3.2.10 12,13-epoxy octadeca-(9Z)-eneoic acid + H2O
-
 Nicotiana tabacum ?
-
 ?
3.3.2.10 12,13-epoxy octadeca-(9Z)-eneoic acid + H2O
-
 Glycine max ?
-
 ?
3.3.2.10 12,13-epoxy octadeca-(9Z)-eneoic acid + H2O
-
 Arabidopsis thaliana ?
-
 ?
3.3.2.10 12,13-epoxy octadeca-(9Z)-eneoic acid + H2O
-
 Brassica napus ?
-
 ?
3.3.2.10 12,13-epoxy octadeca-(9Z)-eneoic acid + H2O
-
 Ricinus communis ?
-
 ?
3.3.2.10 12,13-epoxy octadeca-(9Z)-eneoic acid + H2O
-
 Apium graveolens ?
-
 ?
3.3.2.10 12,13-epoxy octadeca-(9Z)-eneoic acid + H2O
-
 Oryza sativa ?
-
 ?
3.3.2.10 12,13-epoxy octadeca-(9Z)-eneoic acid + H2O
-
 Ananas comosus ?
-
 ?
3.3.2.10 12,13-epoxy octadeca-(9Z)-eneoic acid + H2O
-
 Euphorbia lagascae ?
-
 ?
3.3.2.10 12,13-epoxy octadeca-(9Z)-eneoic acid + H2O
-
 Citrus jambhiri ?
-
 ?
3.3.2.10 12,13-epoxy octadeca-(9Z)-eneoic acid + H2O
-
 Malus pumila ?
-
 ?
3.3.2.10 14,15-leukotriene A4 + H2O
-
 Cavia porcellus ?
-
 ?
3.3.2.10 14R,15S-epoxyeicosatrienoic acid + H2O
-
 Mus musculus 14R,15S-dihydroxyeicosatrienoic acid
-
 ?
3.3.2.10 14S,15R-epoxyeicosatrienoic acid + H2O
-
 Mus musculus 14S,15R-dihydroxyeicosatrienoic acid
-
 ?
3.3.2.10 14S,15S-trans-epoxy-(5Z,8Z,10E,12E)-eicosatetraenoic acid + H2O
-
 Mus musculus 14S,15R-dihydroxy-(5Z,8Z,10E,12E)-eicosatetraenoic acid
-
 ?
3.3.2.10 5,6-leukotriene A4 + H2O
-
 Cavia porcellus ?
-
 ?
3.3.2.10 8R,9S-epoxyeicosatrienoic acid + H2O
-
 Mus musculus 8R,9S-dihydroxyeicosatrienoic acid
-
 ?
3.3.2.10 8S,9R-epoxyeicosatrienoic acid + H2O
-
 Mus musculus 8S,9R-dihydroxyeicosatrienoic acid
-
 ?
3.3.2.10 9(10),12(13)-diepoxyoctadecanoic acid + H2O
-
 Mus musculus 9,10,12,13-tetrahydroxyoctadecanoic acid
-
 ?
3.3.2.10 9,10-epoxy octadeca-(12Z)-eneoic acid + H2O
-
 Vicia sativa ?
-
 ?
3.3.2.10 9,10-epoxy octadeca-(12Z)-eneoic acid + H2O
-
 Spinacia oleracea ?
-
 ?
3.3.2.10 9,10-epoxy octadeca-(12Z)-eneoic acid + H2O
-
 Arabidopsis thaliana ?
-
 ?
3.3.2.10 9,10-epoxy octadeca-(12Z)-eneoic acid + H2O
-
 Brassica napus ?
-
 ?
3.3.2.10 9,10-epoxy octadeca-(12Z)-eneoic acid + H2O
-
 Ricinus communis ?
-
 ?
3.3.2.10 9,10-epoxy octadeca-(12Z)-eneoic acid + H2O
-
 Ananas comosus ?
-
 ?
3.3.2.10 9,10-epoxy octadeca-(12Z)-eneoic acid + H2O
-
 Euphorbia lagascae ?
-
 ?
3.3.2.10 9,10-epoxy octadeca-(12Z)-eneoic acid + H2O
-
 Citrus jambhiri ?
-
 ?
3.3.2.10 9,10-epoxy octadeca-(12Z)-eneoic acid + H2O
-
 Malus pumila ?
-
 ?
3.3.2.10 9,10-epoxy octadeca-(12Z)-eneoic acid + H2O no enantioselectivity Triticum aestivum ?
-
 ?
3.3.2.10 9,10-epoxy octadeca-(12Z)-eneoic acid + H2O no enantioselectivity Zea mays ?
-
 ?
3.3.2.10 9,10-epoxy octadeca-(12Z)-eneoic acid + H2O no enantioselectivity Oryza sativa ?
-
 ?
3.3.2.10 9,10-epoxy octadeca-(12Z)-eneoic acid + H2O no enantioselectivity of infection-induced isozymes, conversion of the (S)-carbon to the corresponding threo-(R,R)-diol in over 85% Nicotiana tabacum ?
-
 ?
3.3.2.10 9,10-epoxy octadeca-(12Z)-eneoic acid + H2O the enzyme prefers the (9R,10S)-enantiomer Apium graveolens ?
-
 ?
3.3.2.10 9,10-epoxy octadeca-(12Z)-eneoic acid + H2O the enzyme prefers the (9R,10S)-enantiomer, conversion of the (S)-carbon to the corresponding threo-(R,R)-diol in over 85% Solanum tuberosum ?
-
 ?
3.3.2.10 9,10-epoxy octadeca-(12Z)-eneoic acid + H2O the enzyme strongly prefers the (9R,10S)-enantiomer, conversion of the (S)-carbon to the corresponding threo-(R,R)-diol in over 85% Glycine max ?
-
 ?
3.3.2.10 9,10-epoxy-18-hydroxy octadeca-(12Z)-eneoic acid + H2O
-
 Vicia sativa ?
-
 ?
3.3.2.10 9,10-epoxy-18-hydroxy octadeca-(12Z)-eneoic acid + H2O
-
 Triticum aestivum ?
-
 ?
3.3.2.10 9,10-epoxy-18-hydroxy octadeca-(12Z)-eneoic acid + H2O
-
 Spinacia oleracea ?
-
 ?
3.3.2.10 9,10-epoxy-18-hydroxy octadeca-(12Z)-eneoic acid + H2O
-
 Zea mays ?
-
 ?
3.3.2.10 9,10-epoxy-18-hydroxy octadeca-(12Z)-eneoic acid + H2O
-
 Solanum tuberosum ?
-
 ?
3.3.2.10 9,10-epoxy-18-hydroxy octadeca-(12Z)-eneoic acid + H2O
-
 Nicotiana tabacum ?
-
 ?
3.3.2.10 9,10-epoxy-18-hydroxy octadeca-(12Z)-eneoic acid + H2O
-
 Glycine max ?
-
 ?
3.3.2.10 9,10-epoxy-18-hydroxy octadeca-(12Z)-eneoic acid + H2O
-
 Arabidopsis thaliana ?
-
 ?
3.3.2.10 9,10-epoxy-18-hydroxy octadeca-(12Z)-eneoic acid + H2O
-
 Brassica napus ?
-
 ?
3.3.2.10 9,10-epoxy-18-hydroxy octadeca-(12Z)-eneoic acid + H2O
-
 Ricinus communis ?
-
 ?
3.3.2.10 9,10-epoxy-18-hydroxy octadeca-(12Z)-eneoic acid + H2O
-
 Apium graveolens ?
-
 ?
3.3.2.10 9,10-epoxy-18-hydroxy octadeca-(12Z)-eneoic acid + H2O
-
 Oryza sativa ?
-
 ?
3.3.2.10 9,10-epoxy-18-hydroxy octadeca-(12Z)-eneoic acid + H2O
-
 Ananas comosus ?
-
 ?
3.3.2.10 9,10-epoxy-18-hydroxy octadeca-(12Z)-eneoic acid + H2O
-
 Euphorbia lagascae ?
-
 ?
3.3.2.10 9,10-epoxy-18-hydroxy octadeca-(12Z)-eneoic acid + H2O
-
 Citrus jambhiri ?
-
 ?
3.3.2.10 9,10-epoxy-18-hydroxy octadeca-(12Z)-eneoic acid + H2O
-
 Malus pumila ?
-
 ?
3.3.2.10 9,10-epoxy-18-hydroxy octadeca-(12Z)-eneoic acid + H2O step in cutin biosynthesis Malus pumila ?
-
 ?
3.3.2.10 9-hydroxy-10,11-epoxy octadeca-(12Z)-eneoic acid + H2O
-
 Vicia sativa ?
-
 ?
3.3.2.10 9-hydroxy-10,11-epoxy octadeca-(12Z)-eneoic acid + H2O
-
 Triticum aestivum ?
-
 ?
3.3.2.10 9-hydroxy-10,11-epoxy octadeca-(12Z)-eneoic acid + H2O
-
 Spinacia oleracea ?
-
 ?
3.3.2.10 9-hydroxy-10,11-epoxy octadeca-(12Z)-eneoic acid + H2O
-
 Zea mays ?
-
 ?
3.3.2.10 9-hydroxy-10,11-epoxy octadeca-(12Z)-eneoic acid + H2O
-
 Solanum tuberosum ?
-
 ?
3.3.2.10 9-hydroxy-10,11-epoxy octadeca-(12Z)-eneoic acid + H2O
-
 Nicotiana tabacum ?
-
 ?
3.3.2.10 9-hydroxy-10,11-epoxy octadeca-(12Z)-eneoic acid + H2O
-
 Glycine max ?
-
 ?
3.3.2.10 9-hydroxy-10,11-epoxy octadeca-(12Z)-eneoic acid + H2O
-
 Arabidopsis thaliana ?
-
 ?
3.3.2.10 9-hydroxy-10,11-epoxy octadeca-(12Z)-eneoic acid + H2O
-
 Brassica napus ?
-
 ?
3.3.2.10 9-hydroxy-10,11-epoxy octadeca-(12Z)-eneoic acid + H2O
-
 Ricinus communis ?
-
 ?
3.3.2.10 9-hydroxy-10,11-epoxy octadeca-(12Z)-eneoic acid + H2O
-
 Apium graveolens ?
-
 ?
3.3.2.10 9-hydroxy-10,11-epoxy octadeca-(12Z)-eneoic acid + H2O
-
 Oryza sativa ?
-
 ?
3.3.2.10 9-hydroxy-10,11-epoxy octadeca-(12Z)-eneoic acid + H2O
-
 Ananas comosus ?
-
 ?
3.3.2.10 9-hydroxy-10,11-epoxy octadeca-(12Z)-eneoic acid + H2O
-
 Euphorbia lagascae ?
-
 ?
3.3.2.10 9-hydroxy-10,11-epoxy octadeca-(12Z)-eneoic acid + H2O
-
 Citrus jambhiri ?
-
 ?
3.3.2.10 9-hydroxy-10,11-epoxy octadeca-(12Z)-eneoic acid + H2O
-
 Malus pumila ?
-
 ?
3.3.2.10 additional information enzyme regulation, overview Homo sapiens ?
-
 ?
3.3.2.10 additional information enzyme regulation, overview Oncorhynchus mykiss ?
-
 ?
3.3.2.10 additional information enzyme regulation, overview Oryzias latipes ?
-
 ?
3.3.2.10 additional information enzyme regulation, overview Pimephales promelas ?
-
 ?
3.3.2.10 additional information enzyme regulation, overview Stenotomus chrysops ?
-
 ?
3.3.2.10 additional information preferred endogenous substrates are epoxides containing fatty acids, e.g. epoxides of stearic and linoleic acids, and hepoxilins Vicia sativa ?
-
 ?
3.3.2.10 additional information preferred endogenous substrates are epoxides containing fatty acids, e.g. epoxides of stearic and linoleic acids, and hepoxilins Triticum aestivum ?
-
 ?
3.3.2.10 additional information preferred endogenous substrates are epoxides containing fatty acids, e.g. epoxides of stearic and linoleic acids, and hepoxilins Spinacia oleracea ?
-
 ?
3.3.2.10 additional information preferred endogenous substrates are epoxides containing fatty acids, e.g. epoxides of stearic and linoleic acids, and hepoxilins Zea mays ?
-
 ?
3.3.2.10 additional information preferred endogenous substrates are epoxides containing fatty acids, e.g. epoxides of stearic and linoleic acids, and hepoxilins Nicotiana tabacum ?
-
 ?
3.3.2.10 additional information preferred endogenous substrates are epoxides containing fatty acids, e.g. epoxides of stearic and linoleic acids, and hepoxilins Glycine max ?
-
 ?
3.3.2.10 additional information preferred endogenous substrates are epoxides containing fatty acids, e.g. epoxides of stearic and linoleic acids, and hepoxilins Arabidopsis thaliana ?
-
 ?
3.3.2.10 additional information preferred endogenous substrates are epoxides containing fatty acids, e.g. epoxides of stearic and linoleic acids, and hepoxilins Brassica napus ?
-
 ?
3.3.2.10 additional information preferred endogenous substrates are epoxides containing fatty acids, e.g. epoxides of stearic and linoleic acids, and hepoxilins Ricinus communis ?
-
 ?
3.3.2.10 additional information preferred endogenous substrates are epoxides containing fatty acids, e.g. epoxides of stearic and linoleic acids, and hepoxilins Apium graveolens ?
-
 ?
3.3.2.10 additional information preferred endogenous substrates are epoxides containing fatty acids, e.g. epoxides of stearic and linoleic acids, and hepoxilins Oryza sativa ?
-
 ?
3.3.2.10 additional information preferred endogenous substrates are epoxides containing fatty acids, e.g. epoxides of stearic and linoleic acids, and hepoxilins Ananas comosus ?
-
 ?
3.3.2.10 additional information preferred endogenous substrates are epoxides containing fatty acids, e.g. epoxides of stearic and linoleic acids, and hepoxilins Euphorbia lagascae ?
-
 ?
3.3.2.10 additional information synthesis of anti-fungal substances in fruits, the enzyme is involved in host-defense and cutin biosynthesis, preferred endogenous substrates are epoxides containing fatty acids, e.g. epoxides of stearic and linoleic acids, and hepoxilins Malus pumila ?
-
 ?
3.3.2.10 additional information the enzyme is involved in host-defense and cutin biosynthesis, preferred endogenous substrates are epoxides containing fatty acids, e.g. epoxides of stearic and linoleic acids, and hepoxilins Citrus jambhiri ?
-
 ?
3.3.2.10 additional information the enzyme is involved in host-defense and cutin biosynthesis, synthesis of (9S,10S,11R)-trihydroxy-12(Z)-octadecenoic and (9S,12S,13S)-trihydroxy-10(E)-octadecenoic acids with potent anti-fungal properties, preferred endogenous substrates are epoxides containing fatty acids, e.g. epoxides of stearic and linoleic acids, and hepoxilins Solanum tuberosum ?
-
 ?
3.3.2.10 additional information the enzyme is involved in metabolism of epoxide lipids in blood pressure, inflammation, reproduction and in lidpi/carbohydrate metabolism, enzyme regulation, overview Cavia porcellus ?
-
 ?
3.3.2.10 additional information the enzyme is involved in metabolism of epoxide lipids in blood pressure, inflammation, reproduction and in lidpi/carbohydrate metabolism, enzyme regulation, overview Rattus norvegicus ?
-
 ?
3.3.2.10 additional information the enzyme is involved in metabolism of epoxide lipids in blood pressure, inflammation, reproduction and in lidpi/carbohydrate metabolism, enzyme regulation, overview Sus scrofa ?
-
 ?
3.3.2.10 additional information the enzyme is involved in metabolism of epoxide lipids in blood pressure, inflammation, reproduction and in lidpi/carbohydrate metabolism, enzyme regulation, overview Oryctolagus cuniculus ?
-
 ?
3.3.2.10 additional information the enzyme is involved in metabolism of epoxide lipids in blood pressure, inflammation, reproduction and in lidpi/carbohydrate metabolism, enzyme regulation, overview Mesocricetus auratus ?
-
 ?
3.3.2.10 additional information the enzyme is involved in metabolism of epoxide lipids in blood pressure, inflammation, reproduction and in lidpi/carbohydrate metabolism, enzyme regulation, overview Equus caballus ?
-
 ?
3.3.2.10 additional information the enzyme is involved in metabolism of epoxide lipids in blood pressure, inflammation, reproduction and in lidpi/carbohydrate metabolism, enzyme regulation, overview Macaca mulatta ?
-
 ?
3.3.2.10 additional information the enzyme is involved in metabolism of epoxide lipids in blood pressure, inflammation, reproduction and in lipid/carbohydrate metabolism, enzyme regulation, overview Papio sp. ?
-
 ?
3.3.2.10 additional information the enzyme is involved in synthesis of tetrahydrofuran diol and trihydroxy furanyl lipids, enzyme regulation, overview Mus musculus ?
-
 ?
3.3.2.10 additional information plant enzymes prefer trans- over cis-epoxides of sterically hindered substrates like stilbene oxides Vicia sativa ?
-
 ?
3.3.2.10 additional information plant enzymes prefer trans- over cis-epoxides of sterically hindered substrates like stilbene oxides Triticum aestivum ?
-
 ?
3.3.2.10 additional information plant enzymes prefer trans- over cis-epoxides of sterically hindered substrates like stilbene oxides Spinacia oleracea ?
-
 ?
3.3.2.10 additional information plant enzymes prefer trans- over cis-epoxides of sterically hindered substrates like stilbene oxides Zea mays ?
-
 ?
3.3.2.10 additional information plant enzymes prefer trans- over cis-epoxides of sterically hindered substrates like stilbene oxides Solanum tuberosum ?
-
 ?
3.3.2.10 additional information plant enzymes prefer trans- over cis-epoxides of sterically hindered substrates like stilbene oxides Nicotiana tabacum ?
-
 ?
3.3.2.10 additional information plant enzymes prefer trans- over cis-epoxides of sterically hindered substrates like stilbene oxides Glycine max ?
-
 ?
3.3.2.10 additional information plant enzymes prefer trans- over cis-epoxides of sterically hindered substrates like stilbene oxides Arabidopsis thaliana ?
-
 ?
3.3.2.10 additional information plant enzymes prefer trans- over cis-epoxides of sterically hindered substrates like stilbene oxides Brassica napus ?
-
 ?
3.3.2.10 additional information plant enzymes prefer trans- over cis-epoxides of sterically hindered substrates like stilbene oxides Ricinus communis ?
-
 ?
3.3.2.10 additional information plant enzymes prefer trans- over cis-epoxides of sterically hindered substrates like stilbene oxides Apium graveolens ?
-
 ?
3.3.2.10 additional information plant enzymes prefer trans- over cis-epoxides of sterically hindered substrates like stilbene oxides Oryza sativa ?
-
 ?
3.3.2.10 additional information plant enzymes prefer trans- over cis-epoxides of sterically hindered substrates like stilbene oxides Ananas comosus ?
-
 ?
3.3.2.10 additional information plant enzymes prefer trans- over cis-epoxides of sterically hindered substrates like stilbene oxides Euphorbia lagascae ?
-
 ?
3.3.2.10 additional information plant enzymes prefer trans- over cis-epoxides of sterically hindered substrates like stilbene oxides Citrus jambhiri ?
-
 ?
3.3.2.10 additional information plant enzymes prefer trans- over cis-epoxides of sterically hindered substrates like stilbene oxides Malus pumila ?
-
 ?
3.3.2.10 additional information substrate specificity, the enzyme prefers trans- over cis-epoxides of sterically hindered substrates like stilbene oxides, the C-terminal domain catalyzes epoxy fatty acid hydrolysis, the N-terminal catalytic domain has also phosphatase activity with specificity for fatty acid diol phosphates, except for the isozyme EPXH2B, overview Mus musculus ?
-
 ?
3.3.2.10 additional information the enzyme prefers trans- over cis-epoxides of sterically hindered substrates like stilbene oxides, the C-terminal domain catalyzes epoxy fatty acid hydrolysis, the N-terminal catalytic domain has also phosphatase activity with specificity for fatty acid diol phosphates Cavia porcellus ?
-
 ?
3.3.2.10 additional information the enzyme prefers trans- over cis-epoxides of sterically hindered substrates like stilbene oxides, the C-terminal domain catalyzes epoxy fatty acid hydrolysis, the N-terminal catalytic domain has also phosphatase activity with specificity for fatty acid diol phosphates Sus scrofa ?
-
 ?
3.3.2.10 additional information the enzyme prefers trans- over cis-epoxides of sterically hindered substrates like stilbene oxides, the C-terminal domain catalyzes epoxy fatty acid hydrolysis, the N-terminal catalytic domain has also phosphatase activity with specificity for fatty acid diol phosphates Oryctolagus cuniculus ?
-
 ?
3.3.2.10 additional information the enzyme prefers trans- over cis-epoxides of sterically hindered substrates like stilbene oxides, the C-terminal domain catalyzes epoxy fatty acid hydrolysis, the N-terminal catalytic domain has also phosphatase activity with specificity for fatty acid diol phosphates Mesocricetus auratus ?
-
 ?
3.3.2.10 additional information the enzyme prefers trans- over cis-epoxides of sterically hindered substrates like stilbene oxides, the C-terminal domain catalyzes epoxy fatty acid hydrolysis, the N-terminal catalytic domain has also phosphatase activity with specificity for fatty acid diol phosphates Equus caballus ?
-
 ?
3.3.2.10 additional information the enzyme prefers trans- over cis-epoxides of sterically hindered substrates like stilbene oxides, the C-terminal domain catalyzes epoxy fatty acid hydrolysis, the N-terminal catalytic domain has also phosphatase activity with specificity for fatty acid diol phosphates Macaca mulatta ?
-
 ?
3.3.2.10 additional information the enzyme prefers trans- over cis-epoxides of sterically hindered substrates like stilbene oxides, the C-terminal domain catalyzes epoxy fatty acid hydrolysis, the N-terminal catalytic domain has also phosphatase activity with specificity for fatty acid diol phosphates Papio sp. ?
-
 ?
3.3.2.10 additional information the enzyme prefers trans- over cis-epoxides of sterically hindered substrates like stilbene oxides, the C-terminal domain catalyzes epoxy fatty acid hydrolysis, the N-terminal catalytic domain has also phosphatase activity with specificity for fatty acid diol phosphates, overview Homo sapiens ?
-
 ?
3.3.2.10 additional information the enzyme prefers trans- over cis-epoxides of sterically hindered substrates like stilbene oxides, the C-terminal domain catalyzes epoxy fatty acid hydrolysis, the N-terminal catalytic domain has also phosphatase activity with specificity for fatty acid diol phosphates, overview Rattus norvegicus ?
-
 ?
3.3.2.10 squalene diepoxide + H2O
-
 Mus musculus ?
-
 ?
3.3.2.10 squalene-2,3-epoxide + H2O
-
 Mus musculus ?
-
 ?

Subunits

EC Number Subunits Comment Organism
3.1.3.76 More the phosphatase activity of the enzyme is located at the N-terminal part, the C-terminal part harbors the epoxide hydrolase activity of EC 3.3.2.10 Homo sapiens
3.3.2.9 ? x * 50000, about Homo sapiens
3.3.2.9 More the enzyme possesses an N-terminal strong hydrophobic transmembrane anchor Homo sapiens
3.3.2.10 dimer 2 * 62000, about Cavia porcellus
3.3.2.10 dimer 2 * 62000, about Homo sapiens
3.3.2.10 dimer 2 * 62000, about Rattus norvegicus
3.3.2.10 dimer 2 * 62000, about Sus scrofa
3.3.2.10 dimer 2 * 62000, about Oryctolagus cuniculus
3.3.2.10 dimer 2 * 62000, about Mesocricetus auratus
3.3.2.10 dimer 2 * 62000, about Equus caballus
3.3.2.10 dimer 2 * 62000, about Macaca mulatta
3.3.2.10 dimer 2 * 62000, about Papio sp.
3.3.2.10 dimer 2 * 62000, about Mus musculus
3.3.2.10 monomer or dimer n * 35000, about Solanum tuberosum
3.3.2.10 monomer or dimer n * 35000, about Glycine max
3.3.2.10 monomer or dimer n * 35000, about Arabidopsis thaliana
3.3.2.10 monomer or dimer n * 35000, about Ricinus communis
3.3.2.10 monomer or dimer x * 35000, about Vicia sativa
3.3.2.10 monomer or dimer x * 35000, about Triticum aestivum
3.3.2.10 monomer or dimer x * 35000, about Spinacia oleracea
3.3.2.10 monomer or dimer x * 35000, about Nicotiana tabacum
3.3.2.10 monomer or dimer x * 35000, about Brassica napus
3.3.2.10 monomer or dimer x * 35000, about Apium graveolens
3.3.2.10 monomer or dimer x * 35000, about Oryza sativa
3.3.2.10 monomer or dimer x * 35000, about Ananas comosus
3.3.2.10 monomer or dimer x * 35000, about Euphorbia lagascae
3.3.2.10 monomer or dimer x * 35000, about Citrus jambhiri
3.3.2.10 monomer or dimer x * 35000, about Malus pumila
3.3.2.10 More the C-terminal domain catalyzes epoxy fatty acid hydrolysis, the N-terminal catalytic domain has also phosphatase activity with specificity for fatty acid diol phosphates Cavia porcellus
3.3.2.10 More the C-terminal domain catalyzes epoxy fatty acid hydrolysis, the N-terminal catalytic domain has also phosphatase activity with specificity for fatty acid diol phosphates Homo sapiens
3.3.2.10 More the C-terminal domain catalyzes epoxy fatty acid hydrolysis, the N-terminal catalytic domain has also phosphatase activity with specificity for fatty acid diol phosphates Rattus norvegicus
3.3.2.10 More the C-terminal domain catalyzes epoxy fatty acid hydrolysis, the N-terminal catalytic domain has also phosphatase activity with specificity for fatty acid diol phosphates Sus scrofa
3.3.2.10 More the C-terminal domain catalyzes epoxy fatty acid hydrolysis, the N-terminal catalytic domain has also phosphatase activity with specificity for fatty acid diol phosphates Oryctolagus cuniculus
3.3.2.10 More the C-terminal domain catalyzes epoxy fatty acid hydrolysis, the N-terminal catalytic domain has also phosphatase activity with specificity for fatty acid diol phosphates Mesocricetus auratus
3.3.2.10 More the C-terminal domain catalyzes epoxy fatty acid hydrolysis, the N-terminal catalytic domain has also phosphatase activity with specificity for fatty acid diol phosphates Equus caballus
3.3.2.10 More the C-terminal domain catalyzes epoxy fatty acid hydrolysis, the N-terminal catalytic domain has also phosphatase activity with specificity for fatty acid diol phosphates Macaca mulatta
3.3.2.10 More the C-terminal domain catalyzes epoxy fatty acid hydrolysis, the N-terminal catalytic domain has also phosphatase activity with specificity for fatty acid diol phosphates Papio sp.
3.3.2.10 More the C-terminal domain catalyzes epoxy fatty acid hydrolysis, the N-terminal catalytic domain has also phosphatase activity with specificity for fatty acid diol phosphates Mus musculus

Synonyms

EC Number Synonyms Comment Organism
3.1.3.76 lipid phosphatase
-
 Homo sapiens
3.1.3.76 More c.f. EC 3.3.2.10 Homo sapiens
3.3.2.9 EPHX1
-
 Homo sapiens
3.3.2.9 mEH
-
 Mus musculus
3.3.2.9 mEH
-
 Homo sapiens
3.3.2.9 mEH
-
 Rattus norvegicus
3.3.2.10 EPXH2
-
 Homo sapiens
3.3.2.10 EPXH2B
-
 Mus musculus
3.3.2.10 SEH
-
 Vicia sativa
3.3.2.10 SEH
-
 Rattus norvegicus
3.3.2.10 SEH
-
 Triticum aestivum
3.3.2.10 SEH
-
 Spinacia oleracea
3.3.2.10 SEH
-
 Zea mays
3.3.2.10 SEH
-
 Solanum tuberosum
3.3.2.10 SEH
-
 Nicotiana tabacum
3.3.2.10 SEH
-
 Glycine max
3.3.2.10 SEH
-
 Arabidopsis thaliana
3.3.2.10 SEH
-
 Brassica napus
3.3.2.10 SEH
-
 Ricinus communis
3.3.2.10 SEH
-
 Apium graveolens
3.3.2.10 SEH
-
 Oryza sativa
3.3.2.10 SEH
-
 Ananas comosus
3.3.2.10 SEH
-
 Papio sp.
3.3.2.10 SEH
-
 Euphorbia lagascae
3.3.2.10 SEH
-
 Citrus jambhiri
3.3.2.10 SEH
-
 Malus pumila

pI Value

EC Number Organism Comment pI Value Maximum pI Value
3.3.2.10 Cavia porcellus
-
 6 5
3.3.2.10 Rattus norvegicus
-
 6 5
3.3.2.10 Sus scrofa
-
 6 5
3.3.2.10 Oryctolagus cuniculus
-
 6 5
3.3.2.10 Mesocricetus auratus
-
 6 5
3.3.2.10 Equus caballus
-
 6 5
3.3.2.10 Macaca mulatta
-
 6 5