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Literature summary extracted from

  • Beaufort, N.; Debela, M.; Creutzburg, S.; Kellermann, J.; Bode, W.; Schmitt, M.; Pidard, D.; Magdolen, V.
    Interplay of human tissue kallikrein 4 (hK4) with the plasminogen activation system: hK4 regulates the structure and functions of the urokinase-type plasminogen activator receptor (uPAR) (2006), Biol. Chem., 387, 217-222.
    View publication on PubMed

Application

EC Number Application Comment Organism
3.4.21.77 medicine enzyme may modulate the tumor-associated urokinase-type plasminogen activator/urokinase-type plasminogen activator receptor-system activity by either activating the pro-enzyme form of plasminogen activator or cleaving the cell surface-associated receptor Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.21.B12 additional information Homo sapiens enzyme modulates the tumor-associated urokinase-type plasminogen activator/urokinase-type plasminogen activator receptor system activity by either activating the pro-enzyme form of urokinase-type plasminogen activator or cleaving the cell surface-associated urokinase-type plasminogen activator receptor ?
-
 ?
3.4.21.35 additional information Homo sapiens tissue kallikrein 4 regulates the structure and functions of the tumor-associated urokinase-type plasminogen activator receptor ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.B12 Homo sapiens
-
-
-
3.4.21.35 Homo sapiens
-
-
-
3.4.21.77 Homo sapiens
-
 isoform tissue kallikrein 4, hK4
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.B12 additional information enzyme modulates the tumor-associated urokinase-type plasminogen activator/urokinase-type plasminogen activator receptor system activity by either activating the pro-enzyme form of urokinase-type plasminogen activator or cleaving the cell surface-associated urokinase-type plasminogen activator receptor Homo sapiens ?
-
 ?
3.4.21.B12 urokinase-type plasminogen activator receptor + H2 cleavage occurs in D1-D2 linker sequence and, to a lesser extent, in D3 juxtamembrane domain Homo sapiens ?
-
 ?
3.4.21.35 additional information tissue kallikrein 4 regulates the structure and functions of the tumor-associated urokinase-type plasminogen activator receptor Homo sapiens ?
-
 ?
3.4.21.77 urokinase-type plasminogen activator receptor + H2O
-
 Homo sapiens ? cleavage within D1-D2 linker sequence and in its D3 juxtamembrane domain ?

Synonyms

EC Number Synonyms Comment Organism
3.4.21.35 tissue kallikrein 4
-
 Homo sapiens
3.4.21.77 K4
-
 Homo sapiens