EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
3.1.1.3 | additional information | phosphorylation at Ser506 activates the enzyme by 100-140% | Rattus norvegicus |
EC Number | Cloned (Comment) | Organism |
---|---|---|
3.1.1.3 | DNA and amino acid sequence determination and analysis, the genes encoding the enzyme are located on chromosome 8 within a cluster of carboxylesterase genes, genetic organization, expression analysis | Mus musculus |
3.1.1.3 | the genes encoding the enzyme are located on chromosome 16 within a cluster of carboxylesterase genes, genetic organization, expression analysis | Homo sapiens |
EC Number | Protein Variants | Comment | Organism |
---|---|---|---|
3.1.1.3 | additional information | a perilipin-regulation mutant shows increased enzyme activity in adipose tissue and increased lipolysis leading to lean mice | Mus musculus |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
3.1.1.3 | endoplasmic reticulum | - |
Mus musculus | 5783 | - |
3.1.1.3 | endoplasmic reticulum | - |
Homo sapiens | 5783 | - |
3.1.1.3 | endoplasmic reticulum | - |
Rattus norvegicus | 5783 | - |
3.1.1.3 | endoplasmic reticulum | - |
Sus scrofa | 5783 | - |
3.1.1.3 | endoplasmic reticulum | - |
Bos taurus | 5783 | - |
3.1.1.3 | lipid droplet | - |
Mus musculus | 5811 | - |
3.1.1.3 | lipid droplet | - |
Homo sapiens | 5811 | - |
3.1.1.3 | lipid droplet | - |
Rattus norvegicus | 5811 | - |
3.1.1.3 | lipid droplet | - |
Sus scrofa | 5811 | - |
3.1.1.3 | lipid droplet | - |
Bos taurus | 5811 | - |
3.1.1.3 | microsome | - |
Mus musculus | - |
- |
3.1.1.3 | microsome | - |
Homo sapiens | - |
- |
3.1.1.3 | microsome | - |
Rattus norvegicus | - |
- |
3.1.1.3 | microsome | - |
Sus scrofa | - |
- |
3.1.1.3 | microsome | - |
Bos taurus | - |
- |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.1.1.3 | additional information | Homo sapiens | the enzyme is involved in basal lipolysis of storage triacylglycerides, and hormonally as well as developmentally regulated, physiological functions, role in apoB-containing lipoprotein assembly in the endoplasmic reticulum, overview | ? | - |
? | |
3.1.1.3 | additional information | Rattus norvegicus | the enzyme is involved in basal lipolysis of storage triacylglycerides, and hormonally as well as developmentally regulated, physiological functions, role in apoB-containing lipoprotein assembly in the endoplasmic reticulum, overview | ? | - |
? | |
3.1.1.3 | additional information | Sus scrofa | the enzyme is involved in basal lipolysis of storage triacylglycerides, and hormonally as well as developmentally regulated, physiological functions, role in apoB-containing lipoprotein assembly in the endoplasmic reticulum, overview | ? | - |
? | |
3.1.1.3 | additional information | Bos taurus | the enzyme is involved in basal lipolysis of storage triacylglycerides, and hormonally as well as developmentally regulated, physiological functions, role in apoB-containing lipoprotein assembly in the endoplasmic reticulum, overview | ? | - |
? | |
3.1.1.3 | additional information | Mus musculus | the enzyme is involved in basal lipolysis of storage triacylglycerides, and hormonally as well as developmentally regulated, the hormone-sensitive lipase is negatively regulated by perilipin in adipose tissue, physiological functions, role in apoB-containing lipoprotein assembly in the endoplasmic reticulum, overview | ? | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.1.1.3 | Bos taurus | - |
- |
- |
3.1.1.3 | Homo sapiens | - |
- |
- |
3.1.1.3 | Mus musculus | - |
- |
- |
3.1.1.3 | Rattus norvegicus | - |
- |
- |
3.1.1.3 | Sus scrofa | - |
- |
- |
EC Number | Posttranslational Modification | Comment | Organism |
---|---|---|---|
3.1.1.3 | glycoprotein | posttranslational regulation by N-glycosylation at Asn79 | Homo sapiens |
3.1.1.3 | glycoprotein | posttranslational regulation by N-glycosylation at Asn79 and Asn489 | Mus musculus |
3.1.1.3 | phosphoprotein | a phosphorylation site is Ser506, phosphorylation activates the enzyme | Rattus norvegicus |
3.1.1.3 | phosphoprotein | phosphorylation sites are Tyr218 and at seven Ser/Thr consensus sequences | Homo sapiens |
EC Number | Purification (Comment) | Organism |
---|---|---|
3.1.1.3 | from liver microsomes | Mus musculus |
3.1.1.3 | from liver microsomes | Homo sapiens |
3.1.1.3 | from liver microsomes | Sus scrofa |
EC Number | Reaction | Comment | Organism | Reaction ID |
---|---|---|---|---|
3.1.1.3 | triacylglycerol + H2O = diacylglycerol + a carboxylate | activation mechanism | Rattus norvegicus | |
3.1.1.3 | triacylglycerol + H2O = diacylglycerol + a carboxylate | active site structure, reaction mechanism | Mus musculus | |
3.1.1.3 | triacylglycerol + H2O = diacylglycerol + a carboxylate | active site structure, reaction mechanism | Homo sapiens |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
3.1.1.3 | adipocyte | hormone-sensitive lipase is negatively regulated by perilipin, lipolysis of storage triacylglycerides | Mus musculus | - |
3.1.1.3 | adipocyte | hormone-sensitive lipase, lipolysis of storage triacylglycerides | Homo sapiens | - |
3.1.1.3 | adipocyte | hormone-sensitive lipase, lipolysis of storage triacylglycerides | Rattus norvegicus | - |
3.1.1.3 | adipocyte | hormone-sensitive lipase, lipolysis of storage triacylglycerides | Sus scrofa | - |
3.1.1.3 | adipocyte | hormone-sensitive lipase, lipolysis of storage triacylglycerides | Bos taurus | - |
3.1.1.3 | heart | - |
Mus musculus | - |
3.1.1.3 | heart | - |
Rattus norvegicus | - |
3.1.1.3 | kidney | - |
Mus musculus | - |
3.1.1.3 | kidney | - |
Rattus norvegicus | - |
3.1.1.3 | liver | - |
Homo sapiens | - |
3.1.1.3 | liver | - |
Rattus norvegicus | - |
3.1.1.3 | liver | - |
Sus scrofa | - |
3.1.1.3 | liver | - |
Bos taurus | - |
3.1.1.3 | liver | regulation of enzyme expression, transcription factor binding, overview | Mus musculus | - |
3.1.1.3 | macrophage | - |
Homo sapiens | - |
3.1.1.3 | additional information | no expression in brain, skeletal muscle, or spleen, tissue-specific functions, expression is developmentally regulated, detailed overview | Mus musculus | - |
3.1.1.3 | additional information | tissue-specific functions, expression is developmentally regulated, detailed overview | Homo sapiens | - |
3.1.1.3 | additional information | tissue-specific functions, expression is developmentally regulated, detailed overview | Rattus norvegicus | - |
3.1.1.3 | additional information | tissue-specific functions, expression is developmentally regulated, detailed overview | Sus scrofa | - |
3.1.1.3 | additional information | tissue-specific functions, expression is developmentally regulated, detailed overview | Bos taurus | - |
3.1.1.3 | small intestine | - |
Mus musculus | - |
3.1.1.3 | small intestine | - |
Homo sapiens | - |
3.1.1.3 | small intestine | - |
Rattus norvegicus | - |
3.1.1.3 | testis | - |
Rattus norvegicus | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.1.1.3 | additional information | the enzyme is involved in basal lipolysis of storage triacylglycerides, and hormonally as well as developmentally regulated, physiological functions, role in apoB-containing lipoprotein assembly in the endoplasmic reticulum, overview | Homo sapiens | ? | - |
? | |
3.1.1.3 | additional information | the enzyme is involved in basal lipolysis of storage triacylglycerides, and hormonally as well as developmentally regulated, physiological functions, role in apoB-containing lipoprotein assembly in the endoplasmic reticulum, overview | Rattus norvegicus | ? | - |
? | |
3.1.1.3 | additional information | the enzyme is involved in basal lipolysis of storage triacylglycerides, and hormonally as well as developmentally regulated, physiological functions, role in apoB-containing lipoprotein assembly in the endoplasmic reticulum, overview | Sus scrofa | ? | - |
? | |
3.1.1.3 | additional information | the enzyme is involved in basal lipolysis of storage triacylglycerides, and hormonally as well as developmentally regulated, physiological functions, role in apoB-containing lipoprotein assembly in the endoplasmic reticulum, overview | Bos taurus | ? | - |
? | |
3.1.1.3 | additional information | the enzyme is involved in basal lipolysis of storage triacylglycerides, and hormonally as well as developmentally regulated, the hormone-sensitive lipase is negatively regulated by perilipin in adipose tissue, physiological functions, role in apoB-containing lipoprotein assembly in the endoplasmic reticulum, overview | Mus musculus | ? | - |
? |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
3.1.1.3 | More | secondary and three-dimensional structure analysis, overview | Mus musculus |
3.1.1.3 | More | secondary and three-dimensional structure analysis, overview | Homo sapiens |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
3.1.1.3 | hormone-sensitive lipase | - |
Mus musculus |
3.1.1.3 | hormone-sensitive lipase | - |
Homo sapiens |
3.1.1.3 | hormone-sensitive lipase | - |
Rattus norvegicus |
3.1.1.3 | hormone-sensitive lipase | - |
Sus scrofa |
3.1.1.3 | hormone-sensitive lipase | - |
Bos taurus |
3.1.1.3 | HSL | - |
Mus musculus |
3.1.1.3 | HSL | - |
Homo sapiens |
3.1.1.3 | HSL | - |
Rattus norvegicus |
3.1.1.3 | HSL | - |
Sus scrofa |
3.1.1.3 | HSL | - |
Bos taurus |
3.1.1.3 | TGH | - |
Mus musculus |
3.1.1.3 | TGH | - |
Homo sapiens |
3.1.1.3 | TGH | - |
Rattus norvegicus |
3.1.1.3 | TGH | - |
Sus scrofa |
3.1.1.3 | TGH | - |
Bos taurus |
3.1.1.3 | triacylglycerol hydrolase | - |
Mus musculus |
3.1.1.3 | triacylglycerol hydrolase | - |
Homo sapiens |
3.1.1.3 | triacylglycerol hydrolase | - |
Rattus norvegicus |
3.1.1.3 | triacylglycerol hydrolase | - |
Sus scrofa |
3.1.1.3 | triacylglycerol hydrolase | - |
Bos taurus |