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Literature summary extracted from

  • Dolinsky, V.W.; Gilham, D.; Alam, M.; Vance, D.E.; Lehner, R.
    Triacylglycerol hydrolase: role in intracellular lipid metabolism (2004), Cell. Mol. Life Sci., 61, 1633-1651.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.1.1.3 additional information phosphorylation at Ser506 activates the enzyme by 100-140% Rattus norvegicus

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.1.1.3 DNA and amino acid sequence determination and analysis, the genes encoding the enzyme are located on chromosome 8 within a cluster of carboxylesterase genes, genetic organization, expression analysis Mus musculus
3.1.1.3 the genes encoding the enzyme are located on chromosome 16 within a cluster of carboxylesterase genes, genetic organization, expression analysis Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
3.1.1.3 additional information a perilipin-regulation mutant shows increased enzyme activity in adipose tissue and increased lipolysis leading to lean mice Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.1.3 endoplasmic reticulum
-
Mus musculus 5783
-
3.1.1.3 endoplasmic reticulum
-
Homo sapiens 5783
-
3.1.1.3 endoplasmic reticulum
-
Rattus norvegicus 5783
-
3.1.1.3 endoplasmic reticulum
-
Sus scrofa 5783
-
3.1.1.3 endoplasmic reticulum
-
Bos taurus 5783
-
3.1.1.3 lipid droplet
-
Mus musculus 5811
-
3.1.1.3 lipid droplet
-
Homo sapiens 5811
-
3.1.1.3 lipid droplet
-
Rattus norvegicus 5811
-
3.1.1.3 lipid droplet
-
Sus scrofa 5811
-
3.1.1.3 lipid droplet
-
Bos taurus 5811
-
3.1.1.3 microsome
-
Mus musculus
-
-
3.1.1.3 microsome
-
Homo sapiens
-
-
3.1.1.3 microsome
-
Rattus norvegicus
-
-
3.1.1.3 microsome
-
Sus scrofa
-
-
3.1.1.3 microsome
-
Bos taurus
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.1.3 additional information Homo sapiens the enzyme is involved in basal lipolysis of storage triacylglycerides, and hormonally as well as developmentally regulated, physiological functions, role in apoB-containing lipoprotein assembly in the endoplasmic reticulum, overview ?
-
?
3.1.1.3 additional information Rattus norvegicus the enzyme is involved in basal lipolysis of storage triacylglycerides, and hormonally as well as developmentally regulated, physiological functions, role in apoB-containing lipoprotein assembly in the endoplasmic reticulum, overview ?
-
?
3.1.1.3 additional information Sus scrofa the enzyme is involved in basal lipolysis of storage triacylglycerides, and hormonally as well as developmentally regulated, physiological functions, role in apoB-containing lipoprotein assembly in the endoplasmic reticulum, overview ?
-
?
3.1.1.3 additional information Bos taurus the enzyme is involved in basal lipolysis of storage triacylglycerides, and hormonally as well as developmentally regulated, physiological functions, role in apoB-containing lipoprotein assembly in the endoplasmic reticulum, overview ?
-
?
3.1.1.3 additional information Mus musculus the enzyme is involved in basal lipolysis of storage triacylglycerides, and hormonally as well as developmentally regulated, the hormone-sensitive lipase is negatively regulated by perilipin in adipose tissue, physiological functions, role in apoB-containing lipoprotein assembly in the endoplasmic reticulum, overview ?
-
?

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.3 Bos taurus
-
-
-
3.1.1.3 Homo sapiens
-
-
-
3.1.1.3 Mus musculus
-
-
-
3.1.1.3 Rattus norvegicus
-
-
-
3.1.1.3 Sus scrofa
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
3.1.1.3 glycoprotein posttranslational regulation by N-glycosylation at Asn79 Homo sapiens
3.1.1.3 glycoprotein posttranslational regulation by N-glycosylation at Asn79 and Asn489 Mus musculus
3.1.1.3 phosphoprotein a phosphorylation site is Ser506, phosphorylation activates the enzyme Rattus norvegicus
3.1.1.3 phosphoprotein phosphorylation sites are Tyr218 and at seven Ser/Thr consensus sequences Homo sapiens

Purification (Commentary)

EC Number Purification (Comment) Organism
3.1.1.3 from liver microsomes Mus musculus
3.1.1.3 from liver microsomes Homo sapiens
3.1.1.3 from liver microsomes Sus scrofa

Reaction

EC Number Reaction Comment Organism Reaction ID
3.1.1.3 triacylglycerol + H2O = diacylglycerol + a carboxylate activation mechanism Rattus norvegicus
3.1.1.3 triacylglycerol + H2O = diacylglycerol + a carboxylate active site structure, reaction mechanism Mus musculus
3.1.1.3 triacylglycerol + H2O = diacylglycerol + a carboxylate active site structure, reaction mechanism Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.1.3 adipocyte hormone-sensitive lipase is negatively regulated by perilipin, lipolysis of storage triacylglycerides Mus musculus
-
3.1.1.3 adipocyte hormone-sensitive lipase, lipolysis of storage triacylglycerides Homo sapiens
-
3.1.1.3 adipocyte hormone-sensitive lipase, lipolysis of storage triacylglycerides Rattus norvegicus
-
3.1.1.3 adipocyte hormone-sensitive lipase, lipolysis of storage triacylglycerides Sus scrofa
-
3.1.1.3 adipocyte hormone-sensitive lipase, lipolysis of storage triacylglycerides Bos taurus
-
3.1.1.3 heart
-
Mus musculus
-
3.1.1.3 heart
-
Rattus norvegicus
-
3.1.1.3 kidney
-
Mus musculus
-
3.1.1.3 kidney
-
Rattus norvegicus
-
3.1.1.3 liver
-
Homo sapiens
-
3.1.1.3 liver
-
Rattus norvegicus
-
3.1.1.3 liver
-
Sus scrofa
-
3.1.1.3 liver
-
Bos taurus
-
3.1.1.3 liver regulation of enzyme expression, transcription factor binding, overview Mus musculus
-
3.1.1.3 macrophage
-
Homo sapiens
-
3.1.1.3 additional information no expression in brain, skeletal muscle, or spleen, tissue-specific functions, expression is developmentally regulated, detailed overview Mus musculus
-
3.1.1.3 additional information tissue-specific functions, expression is developmentally regulated, detailed overview Homo sapiens
-
3.1.1.3 additional information tissue-specific functions, expression is developmentally regulated, detailed overview Rattus norvegicus
-
3.1.1.3 additional information tissue-specific functions, expression is developmentally regulated, detailed overview Sus scrofa
-
3.1.1.3 additional information tissue-specific functions, expression is developmentally regulated, detailed overview Bos taurus
-
3.1.1.3 small intestine
-
Mus musculus
-
3.1.1.3 small intestine
-
Homo sapiens
-
3.1.1.3 small intestine
-
Rattus norvegicus
-
3.1.1.3 testis
-
Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.1.3 additional information the enzyme is involved in basal lipolysis of storage triacylglycerides, and hormonally as well as developmentally regulated, physiological functions, role in apoB-containing lipoprotein assembly in the endoplasmic reticulum, overview Homo sapiens ?
-
?
3.1.1.3 additional information the enzyme is involved in basal lipolysis of storage triacylglycerides, and hormonally as well as developmentally regulated, physiological functions, role in apoB-containing lipoprotein assembly in the endoplasmic reticulum, overview Rattus norvegicus ?
-
?
3.1.1.3 additional information the enzyme is involved in basal lipolysis of storage triacylglycerides, and hormonally as well as developmentally regulated, physiological functions, role in apoB-containing lipoprotein assembly in the endoplasmic reticulum, overview Sus scrofa ?
-
?
3.1.1.3 additional information the enzyme is involved in basal lipolysis of storage triacylglycerides, and hormonally as well as developmentally regulated, physiological functions, role in apoB-containing lipoprotein assembly in the endoplasmic reticulum, overview Bos taurus ?
-
?
3.1.1.3 additional information the enzyme is involved in basal lipolysis of storage triacylglycerides, and hormonally as well as developmentally regulated, the hormone-sensitive lipase is negatively regulated by perilipin in adipose tissue, physiological functions, role in apoB-containing lipoprotein assembly in the endoplasmic reticulum, overview Mus musculus ?
-
?

Subunits

EC Number Subunits Comment Organism
3.1.1.3 More secondary and three-dimensional structure analysis, overview Mus musculus
3.1.1.3 More secondary and three-dimensional structure analysis, overview Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
3.1.1.3 hormone-sensitive lipase
-
Mus musculus
3.1.1.3 hormone-sensitive lipase
-
Homo sapiens
3.1.1.3 hormone-sensitive lipase
-
Rattus norvegicus
3.1.1.3 hormone-sensitive lipase
-
Sus scrofa
3.1.1.3 hormone-sensitive lipase
-
Bos taurus
3.1.1.3 HSL
-
Mus musculus
3.1.1.3 HSL
-
Homo sapiens
3.1.1.3 HSL
-
Rattus norvegicus
3.1.1.3 HSL
-
Sus scrofa
3.1.1.3 HSL
-
Bos taurus
3.1.1.3 TGH
-
Mus musculus
3.1.1.3 TGH
-
Homo sapiens
3.1.1.3 TGH
-
Rattus norvegicus
3.1.1.3 TGH
-
Sus scrofa
3.1.1.3 TGH
-
Bos taurus
3.1.1.3 triacylglycerol hydrolase
-
Mus musculus
3.1.1.3 triacylglycerol hydrolase
-
Homo sapiens
3.1.1.3 triacylglycerol hydrolase
-
Rattus norvegicus
3.1.1.3 triacylglycerol hydrolase
-
Sus scrofa
3.1.1.3 triacylglycerol hydrolase
-
Bos taurus