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Literature summary extracted from

  • Han, M.; Park, D.; Vanderzalm, P.J.; Mains, R.E.; Eipper, B.A.; Taghert, P.H.
    Drosophila uses two distinct neuropeptide amidating enzymes, dPAL1 and dPAL2 (2004), J. Neurochem., 90, 129-141.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
4.3.2.5 Cd2+
-
Drosophila melanogaster
4.3.2.5 Cd2+
-
Rattus norvegicus
4.3.2.5 Co2+
-
Drosophila melanogaster
4.3.2.5 Co2+
-
Rattus norvegicus

Cloned(Commentary)

EC Number Cloned (Comment) Organism
4.3.2.5
-
Drosophila melanogaster
4.3.2.5
-
Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.3.2.5 EDTA 1 mM; 1 mM Drosophila melanogaster

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
4.3.2.5 0.013
-
alpha-N-Acetyl-Tyr-Val-alpha-hydroxyglycine
-
Rattus norvegicus
4.3.2.5 0.045
-
alpha-N-Acetyl-Tyr-Val-alpha-hydroxyglycine
-
Drosophila melanogaster
4.3.2.5 0.238
-
alpha-N-Acetyl-Tyr-Val-alpha-hydroxyglycine
-
Drosophila melanogaster

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
4.3.2.5 endoplasmic reticulum
-
Drosophila melanogaster 5783
-
4.3.2.5 Golgi trans face
-
Drosophila melanogaster
-
-
4.3.2.5 soluble
-
Drosophila melanogaster
-
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
4.3.2.5 Cd2+ activates the enzyme Drosophila melanogaster
4.3.2.5 Cd2+ activates the enzyme Rattus norvegicus
4.3.2.5 Co2+ activates the enzyme Drosophila melanogaster
4.3.2.5 Co2+ activates the enzyme Rattus norvegicus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
4.3.2.5 43900
-
monomer, secreted, rhodopsin-tagged protein, calculated from amino acid sequence Drosophila melanogaster
4.3.2.5 44400
-
monomer, secreted, rhodopsin-tagged protein, calculated from amino acid sequence Drosophila melanogaster
4.3.2.5 49300
-
x * 49300, rhodopsin-tagged protein, SDS-PAGE Drosophila melanogaster
4.3.2.5 51300
-
x * 51300, rhodopsin-tagged protein, SDS-PAGE Drosophila melanogaster

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.3.2.5 peptidylamidoglycolate Drosophila melanogaster
-
peptidyl amide + glyoxylate
-
?
4.3.2.5 peptidylamidoglycolate Rattus norvegicus
-
peptidyl amide + glyoxylate
-
?

Organism

EC Number Organism UniProt Comment Textmining
4.3.2.5 Drosophila melanogaster Q9V5E1
-
-
4.3.2.5 Drosophila melanogaster Q9W1L5
-
-
4.3.2.5 Rattus norvegicus P14925
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
4.3.2.5
-
Drosophila melanogaster
4.3.2.5
-
Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.3.2.5 central nervous system
-
Drosophila melanogaster
-
4.3.2.5 central nervous system
-
Rattus norvegicus
-
4.3.2.5 neuron
-
Drosophila melanogaster
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.3.2.5 alpha-N-acetyl-Tyr-Val-alpha-hydroxyglycine
-
Drosophila melanogaster alpha-N-acetyl-Tyr-Val-NH2 + glyoxylate
-
?
4.3.2.5 alpha-N-acetyl-Tyr-Val-alpha-hydroxyglycine
-
Rattus norvegicus alpha-N-acetyl-Tyr-Val-NH2 + glyoxylate
-
?
4.3.2.5 peptidylamidoglycolate
-
Drosophila melanogaster peptidyl amide + glyoxylate
-
?
4.3.2.5 peptidylamidoglycolate
-
Rattus norvegicus peptidyl amide + glyoxylate
-
?

Subunits

EC Number Subunits Comment Organism
4.3.2.5 ? x * 49300, rhodopsin-tagged protein, SDS-PAGE Drosophila melanogaster
4.3.2.5 ? x * 51300, rhodopsin-tagged protein, SDS-PAGE Drosophila melanogaster

Synonyms

EC Number Synonyms Comment Organism
4.3.2.5 dPAL1 gene product
-
Drosophila melanogaster
4.3.2.5 dPAL2 gene product
-
Drosophila melanogaster
4.3.2.5 PAL
-
Drosophila melanogaster
4.3.2.5 PAL
-
Rattus norvegicus
4.3.2.5 peptidyl-alpha-hydroxyglycine alpha-amidating lyase
-
Drosophila melanogaster
4.3.2.5 peptidyl-alpha-hydroxyglycine alpha-amidating lyase
-
Rattus norvegicus
4.3.2.5 rPAL gene product
-
Rattus norvegicus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
4.3.2.5 6.5
-
-
Drosophila melanogaster
4.3.2.5 7.5
-
-
Drosophila melanogaster