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Literature summary extracted from

  • Garcia-Murillas, I.; Pettitt, T.; Macdonald, E.; Okkenhaug, H.; Georgiev, P.; Trivedi, D.; Hassan, B.; Wakelam, M.; Raghu, P.
    Iazaro encodes a lipid phosphate phosphohydrolase that regulates phosphatidylinositol turnover during Drosophila phototransduction (2006), Neuron, 49, 533-546.
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
3.1.3.4 additional information construction of loss-of-function enzyme mutants by transposon mutagenesis, wild-type enzyme overexpression enhances retinal degeneration of the diacylglycerol kinase causing the rdgA phenotype, overview Drosophila melanogaster

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.3.4 endoplasmic reticulum
-
 Drosophila melanogaster 5783
-
3.1.3.4 membrane
-
 Drosophila melanogaster 16020
-
3.1.3.4 photoreceptor outer segment membrane
-
 Drosophila melanogaster 42622
-
3.1.3.4 plasma membrane
-
 Drosophila melanogaster 5886
-
3.1.3.4 rhabdomere
-
 Drosophila melanogaster 16028
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.3.4 additional information Drosophila melanogaster the enzyme is involved in phototransduction, the enzyme acts synergistically with the diacylglycerol kinase, encoded by gene rdgA, both regulating response termination during phototransduction, regulation of phototransduction and phosphatidyl inositol 4,5-bisphosphate lipid signaling cascade, overview ?
-
 ?
3.1.3.4 phosphatidic acid + H2O Drosophila melanogaster
-
 1,2-diacyl-sn-glycerol + phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.3.4 Drosophila melanogaster
-
 gene Iaza or Iazaro
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.3.4 retina
-
 Drosophila melanogaster
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.1.3.4 additional information
-
-
 Drosophila melanogaster

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.3.4 additional information the enzyme is involved in phototransduction, the enzyme acts synergistically with the diacylglycerol kinase, encoded by gene rdgA, both regulating response termination during phototransduction, regulation of phototransduction and phosphatidyl inositol 4,5-bisphosphate lipid signaling cascade, overview Drosophila melanogaster ?
-
 ?
3.1.3.4 phosphatidic acid + H2O
-
 Drosophila melanogaster 1,2-diacyl-sn-glycerol + phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.3.4 lipid phosphate phosphohydrolase
-
 Drosophila melanogaster
3.1.3.4 LPP
-
 Drosophila melanogaster