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Literature summary extracted from

  • Dal Monte, M.; Del Corso, A.; Moschini, R.; Cappiello, M.; Amodeo, P.; Mura, U.
    Zofenoprilat-glutathione mixed disulfide as a specific S-thiolating agent of bovine lens aldose reductase (2005), Antioxid. Redox Signal., 7, 841-848.
    View publication on PubMed

General Stability

EC Number General Stability Organism
1.1.1.21 DTT stabilizes the purified native enzyme from lens at 2 mM Bos taurus

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.21 zofenoprilat-glutathione disulfide the enzyme is specifically S-thionylated and inactivated by ZSSG, a homodisulfide formed by GSH and zofenoprilat, an angiotensin-converting enzyme inhibitor carrying a thiol group, which is more stable than glutathione, optimization, overview Bos taurus

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.21 Bos taurus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.21 lens
-
 Bos taurus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.1.1.21 0.92
-
 purified native enzyme from lens Bos taurus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.21 glyceraldehyde + NADPH + H+
-
 Bos taurus glycerol + NADP+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.21 aldose reductase
-
 Bos taurus
1.1.1.21 ALR2
-
 Bos taurus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.1.1.21 6.8
-
 assay at Bos taurus

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.21 NADPH
-
 Bos taurus

pI Value

EC Number Organism Comment pI Value Maximum pI Value
1.1.1.21 Bos taurus isoelectric focusing 4.9 4.8