EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.1.1.21 | (5-biphenyl-4-ylmethyl-2,4-dioxothiazolidin-3-yl)acetic acid | IC50: 0.0017 mM | Bos taurus | |
1.1.1.21 | (5-biphenyl-4-ylmethyl-2,4-dioxothiazolidin-3-yl)acetic acid methyl ester | 15% inhibition of ALR2 at 0.05 mM | Bos taurus | |
1.1.1.21 | 5-(3-methoxybenzyl)-2,4-thiazolidinedione | 16% inhibition of ALR2 at 0.05 mM | Bos taurus | |
1.1.1.21 | 5-(3-phenoxybenzyl)-2,4-thiazolidinedione | IC50: 0.0789 mM | Bos taurus | |
1.1.1.21 | 5-(4-benzyloxybenzyl)-2,4-thiazolidinedione | IC50: 0.0314 mM | Bos taurus | |
1.1.1.21 | 5-(4-methoxybenzyl)-2,4-thiazolidinedione | 21% inhibition of ALR2 at 0.05 mM | Bos taurus | |
1.1.1.21 | 5-(4-phenoxybenzyl)-2,4-thiazolidinedione | IC50: 0.0404 mM | Bos taurus | |
1.1.1.21 | 5-biphenyl-4-ylmethyl-2,4-thiazolidinedione | IC50: 0.0658 mM | Bos taurus | |
1.1.1.21 | epalrestat | - |
Bos taurus | |
1.1.1.21 | additional information | poor inhibition by [2,4-dioxo-5-(4-phenoxybenzyl)thiazolidin-3-yl]acetic acid methyl ester | Bos taurus | |
1.1.1.21 | pioglitazone | - |
Bos taurus | |
1.1.1.21 | ponalrestat | IC50: 80 nM | Bos taurus | |
1.1.1.21 | rosiglitazone | - |
Bos taurus | |
1.1.1.21 | sorbinil | IC50: 0.0034 mM | Bos taurus | |
1.1.1.21 | [2,4-dioxo-5-(3-phenoxybenzyl)thiazolidin-3-yl]acetic acid | IC50: 0.0010 mM | Bos taurus | |
1.1.1.21 | [2,4-dioxo-5-(3-phenoxybenzyl)thiazolidin-3-yl]acetic acid methyl ester | 26% inhibition of ALR2 at 0.05 mM | Bos taurus | |
1.1.1.21 | [2,4-dioxo-5-(4-phenoxybenzyl)thiazolidin-3-yl]acetic acid | IC50: 0.0028 mM | Bos taurus | |
1.1.1.21 | [5-(3-methoxybenzyl)-2,4-dioxothiazolidin-3-yl]acetic acid | IC50: 0.0030 mM | Bos taurus | |
1.1.1.21 | [5-(3-methoxybenzyl)-2,4-dioxothiazolidin-3-yl]acetic acid methyl ester | IC50: 0.0211 mM | Bos taurus | |
1.1.1.21 | [5-(4-benzyloxybenzyl)-2,4-dioxothiazolidin-3-yl]acetic acid methyl ester | 24% inhibition of ALR2 at 0.05 mM | Bos taurus | |
1.1.1.21 | [5-(4-hydroxybenzyl)-2,4-dioxothiazolidin-3-yl]acetic acid | IC50: 0.0021 mM | Bos taurus | |
1.1.1.21 | [5-(4-methoxybenzyl)-2,4-dioxothiazolidin-3-yl]acetic acid | IC50: 0.0011 mM | Bos taurus | |
1.1.1.21 | [5-(4-methoxybenzyl)-2,4-dioxothiazolidin-3-yl]acetic acid methyl ester | 24% inhibition of ALR2 at 0.05 mM | Bos taurus |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.1.1.21 | Bos taurus | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
1.1.1.21 | lens | - |
Bos taurus | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.1.1.21 | glyceraldehyde + NADPH + H+ | - |
Bos taurus | glycerol + NADP+ | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.1.1.21 | aldose reductase | - |
Bos taurus |
1.1.1.21 | ALR2 | - |
Bos taurus |
EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|---|
1.1.1.21 | 37 | - |
assay at | Bos taurus |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
1.1.1.21 | 7 | - |
assay at | Bos taurus |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
1.1.1.21 | NADPH | - |
Bos taurus |
EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|---|
1.1.1.21 | 0.00008 | - |
IC50: 80 nM | Bos taurus | ponalrestat | |
1.1.1.21 | 0.001 | - |
IC50: 0.0010 mM | Bos taurus | [2,4-dioxo-5-(3-phenoxybenzyl)thiazolidin-3-yl]acetic acid | |
1.1.1.21 | 0.0011 | - |
IC50: 0.0011 mM | Bos taurus | [5-(4-methoxybenzyl)-2,4-dioxothiazolidin-3-yl]acetic acid | |
1.1.1.21 | 0.0017 | - |
IC50: 0.0017 mM | Bos taurus | (5-biphenyl-4-ylmethyl-2,4-dioxothiazolidin-3-yl)acetic acid | |
1.1.1.21 | 0.0021 | - |
IC50: 0.0021 mM | Bos taurus | [5-(4-hydroxybenzyl)-2,4-dioxothiazolidin-3-yl]acetic acid | |
1.1.1.21 | 0.0028 | - |
IC50: 0.0028 mM | Bos taurus | [2,4-dioxo-5-(4-phenoxybenzyl)thiazolidin-3-yl]acetic acid | |
1.1.1.21 | 0.003 | - |
IC50: 0.0030 mM | Bos taurus | [5-(3-methoxybenzyl)-2,4-dioxothiazolidin-3-yl]acetic acid | |
1.1.1.21 | 0.0034 | - |
IC50: 0.0034 mM | Bos taurus | sorbinil | |
1.1.1.21 | 0.0211 | - |
IC50: 0.0211 mM | Bos taurus | [5-(3-methoxybenzyl)-2,4-dioxothiazolidin-3-yl]acetic acid methyl ester | |
1.1.1.21 | 0.0314 | - |
IC50: 0.0314 mM | Bos taurus | 5-(4-benzyloxybenzyl)-2,4-thiazolidinedione | |
1.1.1.21 | 0.0404 | - |
IC50: 0.0404 mM | Bos taurus | 5-(4-phenoxybenzyl)-2,4-thiazolidinedione | |
1.1.1.21 | 0.0658 | - |
IC50: 0.0658 mM | Bos taurus | 5-biphenyl-4-ylmethyl-2,4-thiazolidinedione | |
1.1.1.21 | 0.0789 | - |
IC50: 0.0789 mM | Bos taurus | 5-(3-phenoxybenzyl)-2,4-thiazolidinedione |