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Literature summary extracted from

  • Findrik, Z.; Poljanac, M.; Vasic-Racki, D.
    Modelling and optimization of the (R)-(+)-3,4-dihydroxyphenyllactic acid production catalyzed with D-lactate dehydrogenase from Lactobacillus leishmannii using genetic algorithm (2005), Chem. Biochem. Eng. Q., 19, 351-358.
No PubMed abstract available

Application

EC Number Application Comment Organism
1.1.1.28 synthesis enzymatic synthesis of (R)-3,4-dihydrixyphenyllactic acid, a pharmacological compound that is used for the treatment of menstrual disorders, menostasis, menorrhalgia, insomnia, blood circulation diseases and Angina pectoris. Regeneration of NADH by formate dehydrogenase system. Use of genetic algorithm as a stochastic optimization method seems to be the best choice for the optimization Lactobacillus leichmannii

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.28 Lactobacillus leichmannii
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.28 3,4-dihydroxyphenylpyruvic acid + NADH + H+
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Lactobacillus leichmannii (R)-3,4-dihydroxyphenyllactic acid + NAD+
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Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.28 NADH
-
Lactobacillus leichmannii