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Literature summary extracted from
- Gene structure, localization and role in oxidative stress of methionine sulfoxide reductase A (MSRA) in the monkey retina (2006), Exp. Eye Res., 82, 816-827.
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 1.8.4.11 | gene msrA, genetic structure, DNA and amino acid sequence determination and analysis, expression of isozymes MsrA1-3 in ARPE cells in the cytosol and in mitochondria | Macaca mulatta |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 1.8.4.11 | cytosol | - |
Macaca mulatta | 5829 | - |
| 1.8.4.11 | mitochondrion | - |
Macaca mulatta | 5739 | - |
| 1.8.4.11 | additional information | subcellular distribution of isozymes MsrA1-3 expression in eye tissue, overview, no localization in endosomes, lysosomes, endoplasmic reticulum, and Golgi apparatus | Macaca mulatta | - |
- |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.8.4.11 | Macaca mulatta | - |
gene msrA, isozymes MsrA1-3 | - |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 1.8.4.11 | native enzyme partially from retina by subcellular fractionation | Macaca mulatta |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.8.4.11 | eye | - |
Macaca mulatta | - |
| 1.8.4.11 | macula lutea | - |
Macaca mulatta | - |
| 1.8.4.11 | retina | peripheral | Macaca mulatta | - |
Specific Activity [micromol/min/mg]
| EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|---|
| 1.8.4.11 | additional information | - |
subcellular distribution of MsrA activity in eye tissue, overview | Macaca mulatta |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.8.4.11 | N-acetyl-L-methionine-(S)-S-oxide + thioredoxin | stereospecific reduction | Macaca mulatta | N-acetyl-L-methionine + thioredoxin disulfide + H2O | - |
? |  |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.8.4.11 | methionine sulfoxide reductase A | - |
Macaca mulatta |
| 1.8.4.11 | MsrA | - |
Macaca mulatta |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.8.4.11 | thioredoxin | - |
Macaca mulatta | |
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Release 2023.1 (January 2023)
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