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Literature summary extracted from

  • Makinen, K.K.; Makinen, P.
    Coccolysin (2004), Handbook of Proteolytic Enzymes(Barrett,A. J. ,Rawlings,N. D. ,Woessner,J. F. ,Eds. )Academic Press, 1, 396-398.
No PubMed abstract available

Application

EC Number Application Comment Organism
3.4.24.30 medicine coccolysin is a virulence factor Enterococcus faecalis

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.24.30 high molecular mass inflammatory factor
-
 Enterococcus faecalis
3.4.24.30 metal chelator inactivates Enterococcus faecalis
3.4.24.30 o-Chloranil is a near-stoichiometric inhibitor of the enzyme Enterococcus faecalis

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.4.24.30 Zn2+
-
 Enterococcus faecalis

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.4.24.30 31500
-
-
 Enterococcus faecalis

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.30 Enterococcus faecalis
-
 var. liquefaciens, straom OG1-10
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.24.30 angiotensin I + H2O
-
 Enterococcus faecalis ?
-
 ?
3.4.24.30 angiotensin II + H2O only cleaved at Tyr-Ile Enterococcus faecalis ?
-
 ?
3.4.24.30 Azocoll + H2O
-
 Enterococcus faecalis ?
-
 ?
3.4.24.30 bradykinin + H2O
-
 Enterococcus faecalis ?
-
 ?
3.4.24.30 casein + H2O
-
 Enterococcus faecalis ?
-
 ?
3.4.24.30 clots milk + H2O
-
 Enterococcus faecalis ?
-
 ?
3.4.24.30 Gelatin + H2O
-
 Enterococcus faecalis ?
-
 ?
3.4.24.30 Hemoglobin + H2O
-
 Enterococcus faecalis ?
-
 ?
3.4.24.30 human endothelin 1 + H2O
-
 Enterococcus faecalis ?
-
 ?
3.4.24.30 insulin B chain + H2O rapidly hydrolyzed at Phe24-Phe25, followed by the cleavage of the His5-Leu6 and other bonds Enterococcus faecalis ?
-
 ?
3.4.24.30 additional information no cleavage of Pz-Pro-Leu-Gly-Pro-D-Arg and 2-FA-Leu-Gly-Pro-Ala Enterococcus faecalis ?
-
 ?
3.4.24.30 pheromone related peptide + H2O
-
 Enterococcus faecalis ?
-
 ?
3.4.24.30 Substance P + H2O
-
 Enterococcus faecalis ?
-
 ?

Subunits

EC Number Subunits Comment Organism
3.4.24.30 monomer
-
 Enterococcus faecalis

Synonyms

EC Number Synonyms Comment Organism
3.4.24.30 metalloendopeptidase II
-
 Enterococcus faecalis
3.4.24.30 microbial proteinase
-
 Enterococcus faecalis
3.4.24.30 streptococcal gelatinase
-
 Enterococcus faecalis

pH Range

EC Number pH Minimum pH Maximum Comment Organism
3.4.24.30 6 8 with azocoll as substrate Enterococcus faecalis
3.4.24.30 7 7.2 with shorter peptides as substrates Enterococcus faecalis