Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Romero-Gomez, M.
    Role of phosphate-activated glutaminase in the pathogenesis of hepatic encephalopathy (2005), Metab. Brain Dis., 20, 319-325.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.5.1.2 angiotensin II activates Homo sapiens
3.5.1.2 glucagon activates Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.5.1.2 6-diazo-5-oxo-L-norleucine blockade of PAG, avoids the toxic effects of Gln accumulation in the brain Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.5.1.2 phosphate phosphate-activated glutaminase isozyme Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.5.1.2 L-glutamine + H2O Homo sapiens glutamine synthesis pathway, overview, the intestinal and brain phosphate-activated glutaminase plays a role in the pathogenesis of hepatic encephalopathy, overview, PAG is increased in cirrhotics showing minimal hepatic encephalopathy and, therefore, could be implicated in the production of systemic hyperammonemia in these patients, PAG localized into the astrocytes is responsible for ammonia and free-radical production, PAG regulation mechanism, overview L-glutamate + NH3
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.5.1.2 Homo sapiens
-
 phosphate-activated isozyme, kidney type isozyme K-PAG and the hepatic type isozyme L-PAG
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.5.1.2 astrocyte phosphate-activated isozyme Homo sapiens
-
3.5.1.2 brain phosphate-activated isozyme, isozyme K-PAG Homo sapiens
-
3.5.1.2 duodenum phosphate-activated isozyme, mucosa Homo sapiens
-
3.5.1.2 gastrointestinal tract phosphate-activated isozyme Homo sapiens
-
3.5.1.2 gut phosphate-activated isozyme Homo sapiens
-
3.5.1.2 kidney isozyme K-PAG Homo sapiens
-
3.5.1.2 liver phosphate-activated isozyme, isozyme L-PAG Homo sapiens
-
3.5.1.2 additional information isozyme tissue distribution, overview, isozyme K-PAG is located in kidney, brain, and villus enterocyte, while isozyme L-PAG is restricted to the liver Homo sapiens
-
3.5.1.2 mucosa duodenal Homo sapiens
-
3.5.1.2 small intestine phosphate-activated isozyme Homo sapiens
-
3.5.1.2 villus isozyme K-PAG Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.5.1.2 L-glutamine + H2O
-
 Homo sapiens L-glutamate + NH3
-
 ?
3.5.1.2 L-glutamine + H2O glutamine synthesis pathway, overview, the intestinal and brain phosphate-activated glutaminase plays a role in the pathogenesis of hepatic encephalopathy, overview, PAG is increased in cirrhotics showing minimal hepatic encephalopathy and, therefore, could be implicated in the production of systemic hyperammonemia in these patients, PAG localized into the astrocytes is responsible for ammonia and free-radical production, PAG regulation mechanism, overview Homo sapiens L-glutamate + NH3
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.5.1.2 PAG
-
 Homo sapiens
3.5.1.2 phosphate-activated glutaminase
-
 Homo sapiens