Any feedback?
Literature summary extracted from
- 11beta-Hydroxysteroid dehydrogenase type 1: purification from human liver and characterization as carbonyl reductase of xenobiotics (2006), Mol. Cell. Endocrinol., 248, 34-37.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.1.1.146 | glycyrrhetinic acid | inhibits both 11beta-hydroxysteroid dehydrogenase and carbonyl reductase activities of the enzyme potently | Homo sapiens |  |
| 1.1.1.184 | glycyrrhetinic acid | inhibits both 11beta-hydroxysteroid dehydrogenase and carbonyl reductase activities of the enzyme potently | Homo sapiens | |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 1.1.1.146 | additional information | - |
additional information | the glucocorticoid and xenobiotic reductase activities show cooperative kinetics | Homo sapiens | |
| 1.1.1.184 | additional information | - |
additional information | the glucocorticoid and xenobiotic reductase activities show cooperative kinetics | Homo sapiens |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 1.1.1.146 | endoplasmic reticulum membrane | - |
Homo sapiens | 5789 | - |
| 1.1.1.146 | microsome | - |
Homo sapiens | - |
- |
| 1.1.1.184 | endoplasmic reticulum membrane | - |
Homo sapiens | 5789 | - |
| 1.1.1.184 | microsome | - |
Homo sapiens | - |
- |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 1.1.1.146 | 34000 | - |
2 * 34000, SDS-PAGE | Homo sapiens |
| 1.1.1.146 | 67400 | - |
gel filtration | Homo sapiens |
| 1.1.1.184 | 34000 | - |
2 * 34000, SDS-PAGE | Homo sapiens |
| 1.1.1.184 | 67400 | - |
gel filtration | Homo sapiens |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.1.1.146 | 4-methylnitrosamino-1-(3-pyridyl)-1-butanone + NADPH | Homo sapiens | i.e. NNK, genotoxic compound from tobacco smoke, isozyme 11beta-HSD1, carbonyl reductase activity, EC 1.1.1.184 | 4-methylnitrosamino-1-(3-pyridyl)-1-butanol + NADP+ | - |
r | |
| 1.1.1.146 | cortisone + NADPH + H+ | Homo sapiens | isozyme 11beta-HSD1, 11beta-hydroxysteroid dehydrogenase activity, EC 1.1.1.146 | cortisol + NADP+ | - |
r | |
| 1.1.1.146 | dehydrocorticosterone + NADPH | Homo sapiens | isozyme 11beta-HSD1, 11beta-hydroxysteroid dehydrogenase activity, EC 1.1.1.146 | corticosterone + NADP+ | - |
r | |
| 1.1.1.146 | additional information | Homo sapiens | the enzyme interconvertes 11-oxo-glucocorticoids to their 11-hydroxy metabolites, reaction of EC 1.1.1.146, but is also active as carbonyl reductase, EC 1.1.1.184, in detoxification of xenobiotic carbonyl compounds reducing them to alcohols that are easier to conjugate and eliminate | ? | - |
? | |
| 1.1.1.146 | oracin + NADPH + H+ | Homo sapiens | a cytostatic drug, isozyme 11beta-HSD1, carbonyl reductase activity, EC 1.1.1.184, stereochemical ratio of 3:1 for R:S enantiomers of the pro-chiral carbonyl centre of oracin, inactivation of the anti-cancer drug | dihydrooracin + NADP+ | - |
r | |
| 1.1.1.184 | 4-methylnitrosamino-1-(3-pyridyl)-1-butanone + NADPH + H+ | Homo sapiens | i.e. NNK, genotoxic compound from tobacco smoke, isozyme 11beta-HSD1, carbonyl reductase activity, EC 1.1.1.184 | 4-methylnitrosamino-1-(3-pyridyl)-1-butanol + NADP+ | - |
r | |
| 1.1.1.184 | additional information | Homo sapiens | the enzyme interconvertes 11-oxo-glucocorticoids to their 11-hydroxy metabolites, reaction of EC 1.1.1.146, but is also active as carbonyl reductase, EC 1.1.1.184, in detoxification of xenobiotic carbonyl compounds reducing them to alcohols that are easier to conjugate and eliminate | ? | - |
? | |
| 1.1.1.184 | oracin + NADPH + H+ | Homo sapiens | a cytostatic drug, isozyme 11beta-HSD1, carbonyl reductase activity, EC 1.1.1.184, stereochemical ratio of 3:1 for R:S enantiomers of the pro-chiral carbonyl centre of oracin, inactivation of the anti-cancer drug | dihydrooracin + NADP+ | - |
r | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.1.1.146 | Homo sapiens | - |
- |
- |
| 1.1.1.184 | Homo sapiens | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 1.1.1.146 | native enzyme from liver microsomes to homogeneity | Homo sapiens |
| 1.1.1.184 | native enzyme from liver microsomes to homogeneity | Homo sapiens |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.1.1.146 | liver | - |
Homo sapiens | - |
| 1.1.1.146 | lung | - |
Homo sapiens | - |
| 1.1.1.184 | liver | - |
Homo sapiens | - |
| 1.1.1.184 | lung | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.1.1.146 | 4-methylnitrosamino-1-(3-pyridyl)-1-butanone + NADPH | i.e. NNK, genotoxic compound from tobacco smoke, isozyme 11beta-HSD1, carbonyl reductase activity, EC 1.1.1.184 | Homo sapiens | 4-methylnitrosamino-1-(3-pyridyl)-1-butanol + NADP+ | - |
r | |
| 1.1.1.146 | cortisone + NADPH + H+ | isozyme 11beta-HSD1, 11beta-hydroxysteroid dehydrogenase activity, EC 1.1.1.146 | Homo sapiens | cortisol + NADP+ | - |
r | |
| 1.1.1.146 | dehydrocorticosterone + NADPH | isozyme 11beta-HSD1, 11beta-hydroxysteroid dehydrogenase activity, EC 1.1.1.146 | Homo sapiens | corticosterone + NADP+ | - |
r | |
| 1.1.1.146 | additional information | the enzyme interconvertes 11-oxo-glucocorticoids to their 11-hydroxy metabolites, reaction of EC 1.1.1.146, but is also active as carbonyl reductase, EC 1.1.1.184, in detoxification of xenobiotic carbonyl compounds reducing them to alcohols that are easier to conjugate and eliminate | Homo sapiens | ? | - |
? | |
| 1.1.1.146 | additional information | the enzyme shows pluripotent substrate specificity being active as 11beta-hydroxysteroid dehydrogenase, EC 1.1.1.146, and carbonyl reductase, EC 1.1.1.184 | Homo sapiens | ? | - |
? | |
| 1.1.1.146 | oracin + NADPH + H+ | a cytostatic drug, isozyme 11beta-HSD1, carbonyl reductase activity, EC 1.1.1.184, stereochemical ratio of 3:1 for R:S enantiomers of the pro-chiral carbonyl centre of oracin, inactivation of the anti-cancer drug | Homo sapiens | dihydrooracin + NADP+ | - |
r | |
| 1.1.1.184 | 4-methylnitrosamino-1-(3-pyridyl)-1-butanone + NADPH + H+ | i.e. NNK, genotoxic compound from tobacco smoke, isozyme 11beta-HSD1, carbonyl reductase activity, EC 1.1.1.184 | Homo sapiens | 4-methylnitrosamino-1-(3-pyridyl)-1-butanol + NADP+ | - |
r | |
| 1.1.1.184 | additional information | the enzyme interconvertes 11-oxo-glucocorticoids to their 11-hydroxy metabolites, reaction of EC 1.1.1.146, but is also active as carbonyl reductase, EC 1.1.1.184, in detoxification of xenobiotic carbonyl compounds reducing them to alcohols that are easier to conjugate and eliminate | Homo sapiens | ? | - |
? | |
| 1.1.1.184 | additional information | the enzyme shows pluripotent substrate specificity being active as 11beta-hydroxysteroid dehydrogenase, EC 1.1.1.146, and carbonyl reductase, EC 1.1.1.184 | Homo sapiens | ? | - |
? | |
| 1.1.1.184 | oracin + NADPH + H+ | a cytostatic drug, isozyme 11beta-HSD1, carbonyl reductase activity, EC 1.1.1.184, stereochemical ratio of 3:1 for R:S enantiomers of the pro-chiral carbonyl centre of oracin, inactivation of the anti-cancer drug | Homo sapiens | dihydrooracin + NADP+ | - |
r | |
| 1.1.1.184 | oracin + NADPH + H+ | a cytostatic drug, isozyme 11beta-HSD1, carbonyl reductase activity, EC 1.1.1.184, stereochemical ratio of 3:1 for R:S enantiomers of the pro-chiral carbonyl centre of oracin, inactivation reaction | Homo sapiens | dihydrooracin + NADP+ | - |
r | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 1.1.1.146 | dimer | 2 * 34000, SDS-PAGE | Homo sapiens |
| 1.1.1.184 | dimer | 2 * 34000, SDS-PAGE | Homo sapiens |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.1.1.146 | 11beta-HSD1 | - |
Homo sapiens |
| 1.1.1.146 | 11beta-hydroxysteroid dehydrogenase type 1 | - |
Homo sapiens |
| 1.1.1.146 | More | cf. EC 1.1.1.184 | Homo sapiens |
| 1.1.1.184 | xenobiotic carbonyl reductase | - |
Homo sapiens |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.1.1.146 | NADP+ | - |
Homo sapiens | |
| 1.1.1.146 | NADPH | - |
Homo sapiens | |
| 1.1.1.184 | NADP+ | - |
Homo sapiens | |
| 1.1.1.184 | NADPH | - |
Homo sapiens | |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
