EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
3.4.21.B6 | CHAPS | increases enzyme activity up to 4fold with increasing concentration | Homo sapiens | |
3.4.21.B6 | DMSO | increases enzyme activity up to 2fold with increasing concentration | Homo sapiens | |
3.4.21.B6 | additional information | NP-40, Triton X-100, 15% glycerol, up to 0.5 mM DTT and 0.25 mM beta-mercaptoethanol have no effect on enzyme activity | Homo sapiens | |
3.4.21.B6 | ZnCl2 | with acetyl-PRLR-7-amino-3-carbamoylmethyl-4-methylcoumarin | Homo sapiens |
EC Number | Cloned (Comment) | Organism |
---|---|---|
3.4.21.B6 | expression in Sf9 cells | Homo sapiens |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
3.4.21.B6 | Aprotinin | - |
Homo sapiens | |
3.4.21.B6 | Brij 35 | activity decreases with increasing detergent concentration | Homo sapiens | |
3.4.21.B6 | CaCl2 | - |
Homo sapiens | |
3.4.21.B6 | CoCl2 | - |
Homo sapiens | |
3.4.21.B6 | CuCl2 | - |
Homo sapiens | |
3.4.21.B6 | EDTA | reduces enzyme activity by 30% | Homo sapiens | |
3.4.21.B6 | LiCl | - |
Homo sapiens | |
3.4.21.B6 | MgCl2 | - |
Homo sapiens | |
3.4.21.B6 | additional information | not inhibited by alpha1-antitrypsin, alpha1-antitrypsinPDX, alpha1-antichymotrypsin, and soybean trypsin inhibitor | Homo sapiens | |
3.4.21.B6 | NaCl | - |
Homo sapiens | |
3.4.21.B6 | NaF | - |
Homo sapiens | |
3.4.21.B6 | NaI | - |
Homo sapiens | |
3.4.21.B6 | NiCl2 | - |
Homo sapiens | |
3.4.21.B6 | placental bikunin | - |
Homo sapiens | |
3.4.21.B6 | Tween 20 | activity decreases with increasing detergent concentration | Homo sapiens | |
3.4.21.B6 | ZnCl2 | with acetyl-KHYR-7-amino-3-carbamoylmethyl-4-methylcoumarin | Homo sapiens |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
3.4.21.B6 | 0.0555 | - |
acetyl-KDYR-7-amido-4-carbamoylmethylcoumarin | with ZnCL2 | Homo sapiens | |
3.4.21.B6 | 0.0786 | - |
acetyl-PRLR-7-amido-4-carbamoylmethylcoumarin | without ZnCL2 | Homo sapiens | |
3.4.21.B6 | 0.141 | - |
acetyl-PRLR-7-amido-4-carbamoylmethylcoumarin | with ZnCL2 | Homo sapiens | |
3.4.21.B6 | 0.193 | - |
acetyl-KHYR-7-amido-4-carbamoylmethylcoumarin | - |
Homo sapiens | |
3.4.21.B6 | 0.219 | - |
acetyl-KDYR-7-amido-4-carbamoylmethylcoumarin | without ZnCL2 | Homo sapiens | |
3.4.21.B6 | 0.86 | - |
acetyl-KDYR-7-amido-4-carbamoylmethylcoumarin | - |
Homo sapiens |
EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
3.4.21.B6 | 40000 | - |
SDS-PAGE, glycosylated enzyme | Homo sapiens |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.4.21.B6 | Homo sapiens | - |
- |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
3.4.21.B6 | by gel filtration | Homo sapiens |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.4.21.B6 | 7-amido-4-carbamoylmethylcoumarin-KHYRSVAS-K(DNP)R + H2O | - |
Homo sapiens | ? | - |
? | |
3.4.21.B6 | 7-amido-4-carbamoylmethylcoumarin-KHYRSVAW-K(DNP)R + H2O | - |
Homo sapiens | ? | - |
? | |
3.4.21.B6 | acetyl-DHYR-7-amido-4-carbamoylmethylcoumarin + H2O | suboptimal substrate | Homo sapiens | acetyl-DHYR + 7-amino-4-carbamoylmethylcoumarin | - |
? | |
3.4.21.B6 | acetyl-KDYR-7-amido-4-carbamoylmethylcoumarin + H2O | suboptimal substrate | Homo sapiens | acetyl-KDYR + 7-amino-4-carbamoylmethylcoumarin | - |
? | |
3.4.21.B6 | acetyl-KHDR-7-amido-4-carbamoylmethylcoumarin + H2O | suboptimal substrate | Homo sapiens | acetyl-KHDR + 7-amino-4-carbamoylmethylcoumarin | - |
? | |
3.4.21.B6 | acetyl-KHYR-7-amido-4-carbamoylmethylcoumarin + H2O | - |
Homo sapiens | acetyl-KHYR + 7-amino-4-carbamoylmethylcoumarin | - |
? | |
3.4.21.B6 | acetyl-KHYR-7-amido-4-carbamoylmethylcoumarin + H2O | optimal substrate | Homo sapiens | acetyl-KHYR + 7-amino-4-carbamoylmethylcoumarin | - |
? | |
3.4.21.B6 | acetyl-KHYR-7-amido-4-methylcoumarin + H2O | - |
Homo sapiens | acetyl-KHYR + 7-amino-4-methylcoumarin | - |
? | |
3.4.21.B6 | acetyl-PRLR-7-amido-4-carbamoylmethylcoumarin + H2O | suboptimal substrate | Homo sapiens | acetyl-PRLR + 7-amino-4-carbamoylmethylcoumarin | - |
? | |
3.4.21.B6 | additional information | 7-amido-4-carbamoylmethylcoumarin-KHYRIVAS-K(DNP)R completely inactive | Homo sapiens | ? | - |
? |
EC Number | Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
3.4.21.B6 | 0.083 | - |
acetyl-KDYR-7-amido-4-carbamoylmethylcoumarin | - |
Homo sapiens | |
3.4.21.B6 | 0.381 | - |
acetyl-PRLR-7-amido-4-carbamoylmethylcoumarin | with ZnCL2 | Homo sapiens | |
3.4.21.B6 | 0.601 | - |
acetyl-PRLR-7-amido-4-carbamoylmethylcoumarin | without ZnCL2 | Homo sapiens | |
3.4.21.B6 | 1.97 | - |
acetyl-KHYR-7-amido-4-carbamoylmethylcoumarin | - |
Homo sapiens | |
3.4.21.B6 | 2.38 | - |
acetyl-KDYR-7-amido-4-carbamoylmethylcoumarin | without ZnCL2 | Homo sapiens | |
3.4.21.B6 | 6.08 | - |
acetyl-PRLR-7-amido-4-carbamoylmethylcoumarin | without ZnCL2 | Homo sapiens | |
3.4.21.B6 | 6.53 | - |
acetyl-KDYR-7-amido-4-carbamoylmethylcoumarin | with ZnCL2 | Homo sapiens |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
3.4.21.B6 | 9 | - |
- |
Homo sapiens |
EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|---|
3.4.21.B6 | 0.0000014 | - |
Aprotinin | - |
Homo sapiens | |
3.4.21.B6 | 0.000005 | - |
placental bikunin | - |
Homo sapiens | |
3.4.21.B6 | 0.0021 | - |
CuCl2 | with acetyl-PRLR-7-amido-4-carbamoylmethylcoumarin | Homo sapiens | |
3.4.21.B6 | 0.0048 | - |
ZnCl2 | with acetyl-PRLR-7-amido-4-carbamoylmethylcoumarin | Homo sapiens | |
3.4.21.B6 | 0.01 | - |
NiCl2 | with acetyl-PRLR-7-amido-4-carbamoylmethylcoumarin | Homo sapiens | |
3.4.21.B6 | 0.047 | - |
CoCl2 | with acetyl-PRLR-7-amido-4-carbamoylmethylcoumarin | Homo sapiens | |
3.4.21.B6 | 0.57 | - |
CoCl2 | with acetyl-KHYR-7-amido-4-carbamoylmethylcoumarin | Homo sapiens | |
3.4.21.B6 | 1.15 | - |
CaCl2 | with acetyl-KHYR-7-amido-4-carbamoylmethylcoumarin | Homo sapiens | |
3.4.21.B6 | 1.42 | - |
MgCl2 | with acetyl-KHYR-7-amido-4-carbamoylmethylcoumarin | Homo sapiens | |
3.4.21.B6 | 16.4 | - |
NaI | with acetyl-KHYR-7-amido-4-carbamoylmethylcoumarin | Homo sapiens | |
3.4.21.B6 | 21.3 | - |
LiCl | with acetyl-KHYR-7-amido-4-carbamoylmethylcoumarin | Homo sapiens | |
3.4.21.B6 | 22.4 | - |
NaCl | with acetyl-KHYR-7-amido-4-carbamoylmethylcoumarin | Homo sapiens | |
3.4.21.B6 | 26.3 | - |
NaF | with acetyl-KHYR-7-amido-4-carbamoylmethylcoumarin | Homo sapiens |