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Literature summary extracted from
- Specific modification of a Na+ binding site in NADH:quinone oxidoreductase from Klebsiella pneumoniae with dicyclohexylcarbodiimide (2006), J. Bacteriol., 188, 3264-3272.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 7.2.1.1 | annonin VI | IC50: 0.05 mM | Klebsiella pneumoniae |  |
| 7.2.1.1 | additional information | not inhibited by 0.04 mM Ag+ | Klebsiella pneumoniae |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 7.2.1.1 | membrane | - |
Klebsiella pneumoniae | 16020 | - |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 7.2.1.1 | Klebsiella pneumoniae | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 7.2.1.1 | Fractogel DEAE-650(S) column chromatography and Source 15Q Superformance column chromatography | Klebsiella pneumoniae |
Specific Activity [micromol/min/mg]
| EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|---|
| 7.2.1.1 | 0.22 | - |
in solubilized membranes | Klebsiella pneumoniae |
| 7.2.1.1 | 0.77 | - |
after purification | Klebsiella pneumoniae |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 7.2.1.1 | NADH + N',N'-dicyclohexylcarbodiimide | - |
Klebsiella pneumoniae | NAD+ + ? | - |
? | |
| 7.2.1.1 | NADH + ubiquinone-1 | - |
Klebsiella pneumoniae | NAD+ + ubiquinol-1 | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 7.2.1.1 | multimer | - |
Klebsiella pneumoniae |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 7.2.1.1 | Na+-translocating complex 1 | - |
Klebsiella pneumoniae |
| 7.2.1.1 | Na+-translocating NADH:quinone oxidoreductase | - |
Klebsiella pneumoniae |
| 7.2.1.1 | NDH-1 | - |
Klebsiella pneumoniae |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 7.2.1.1 | 7.5 | - |
- |
Klebsiella pneumoniae |
IC50 Value
| EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|---|
| 7.2.1.1 | 0.05 | - |
IC50: 0.05 mM | Klebsiella pneumoniae | annonin VI | |
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Release 2023.1 (January 2023)
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