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Literature summary extracted from

  • Hsu, H.T.; Chang, Y.C.; Chiu, Y.N.; Liu, C.L.; Chang, K.J.; Guo, I.C.
    Leptin interferes with adrenocorticotropin/3',5'-cyclic adenosine monophosphate (cAMP) signaling, possibly through a janus kinase 2-phosphatidylinositol 3-kinase/akt-phosphodiesterase 3-cAMP pathway, to down-regulate cholesterol side-chain cleavage cytochrome P450 enzyme in human adrenocortical NCI-H295 cell line (2006), J. Clin. Endocrinol. Metab., 91, :2761-2769.
No PubMed abstract available

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.15.6 additional information leptin interferes with adrenocorticotropin/cAMP signaling, possibly through a janus kinase 2-phosphatidylinositol 3-kinase/akt-phosphodiesterase 3-cAMP pathway, to down-regulate the enzyme in NCI-H295 cells, leptin negatively controls ACTH/cholera toxin-induced CYP11A1 promoter activity to inhibit P450scc expression, mechanism, overview Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.15.6 cholesterol + reduced adrenal ferredoxin + O2 Homo sapiens first and rate-limiting enzyme in adrenal steroidogenesis pregnenolone + 4-methylpentanal + oxidized adrenal ferredoxin
-
?
1.14.15.6 additional information Homo sapiens leptin interferes with adrenocorticotropin/cAMP signaling, possibly through a janus kinase 2-phosphatidylinositol 3-kinase/akt-phosphodiesterase 3-cAMP pathway, to down-regulate cholesterol side-chain cleavage cytochrome P450 enzyme in human adrenocortical NCI-H295 cell line, mechanism, overview ?
-
?

Organism

EC Number Organism UniProt Comment Textmining
1.14.15.6 Homo sapiens
-
gene CYP11A1
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.15.6 NCI-H295 cell adrenocortical cell line Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.15.6 cholesterol + reduced adrenal ferredoxin + O2
-
Homo sapiens pregnenolone + 4-methylpentanal + oxidized adrenal ferredoxin
-
?
1.14.15.6 cholesterol + reduced adrenal ferredoxin + O2 first and rate-limiting enzyme in adrenal steroidogenesis Homo sapiens pregnenolone + 4-methylpentanal + oxidized adrenal ferredoxin
-
?
1.14.15.6 additional information leptin interferes with adrenocorticotropin/cAMP signaling, possibly through a janus kinase 2-phosphatidylinositol 3-kinase/akt-phosphodiesterase 3-cAMP pathway, to down-regulate cholesterol side-chain cleavage cytochrome P450 enzyme in human adrenocortical NCI-H295 cell line, mechanism, overview Homo sapiens ?
-
?

Synonyms

EC Number Synonyms Comment Organism
1.14.15.6 cholesterol side-chain cleavage cytochrome P450 enzyme
-
Homo sapiens
1.14.15.6 P450 cholesterol side-chain cleavage enzyme
-
Homo sapiens
1.14.15.6 P450scc
-
Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.15.6 reduced adrenal ferredoxin
-
Homo sapiens