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Literature summary extracted from

  • Lane, K.T.; Beese, L.S.
    Thematic review series: lipid posttranslational modifications. Structural biology of protein farnesyltransferase and geranylgeranyltransferase type I (2006), J. Lipid Res., 47, 681-699.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.5.1.58 ABT-839
-
 Homo sapiens
2.5.1.58 BMS-214662
-
 Homo sapiens
2.5.1.58 L-778,123
-
 Homo sapiens
2.5.1.58 R115777
-
 Homo sapiens
2.5.1.58 SCH66336
-
 Homo sapiens
2.5.1.59 L-778,123
-
 Rattus norvegicus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.5.1.58 Mg2+ required, stabilizes the developing negative charge on the diphosphate as the bond breaks between the a-phosphate and the C1 atom of the farnesyl group Homo sapiens
2.5.1.58 Zn2+ contains one Zn2+ ion per dimer, required for catalysis and peptide binding Homo sapiens
2.5.1.59 Zn2+ required for catalysis and peptide binding, one zinc ion per protein dimer Rattus norvegicus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.5.1.58 46000
-
 1 * 48000 + 1 * 46000 Homo sapiens
2.5.1.58 48000
-
 1 * 48000 + 1 * 46000 Homo sapiens
2.5.1.59 43000
-
 1 * 43000 + 1 * 48000 Rattus norvegicus
2.5.1.59 48000
-
 1 * 43000 + 1 * 48000 Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
2.5.1.58 Homo sapiens
-
-
-
2.5.1.59 Rattus norvegicus
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.5.1.58 farnesyl diphosphate + protein-cysteine
-
 Homo sapiens diphosphate + S-farnesyl protein
-
 ir
2.5.1.59 geranylgeranyl diphosphate + Cys-Val-Leu-Leu
-
 Rattus norvegicus S-geranylgeranyl-Cys-Val-Leu-Leu + diphosphate
-
 ?
2.5.1.59 geranylgeranyl diphosphate + Cys-Val-Leu-Ser
-
 Rattus norvegicus S-geranylgeranyl-Cys-Val-Leu-Ser + diphosphate
-
 ?

Subunits

EC Number Subunits Comment Organism
2.5.1.58 heterodimer 1 * 48000 + 1 * 46000 Homo sapiens
2.5.1.59 heterodimer 1 * 43000 + 1 * 48000 Rattus norvegicus

Synonyms

EC Number Synonyms Comment Organism
2.5.1.58 FTase
-
 Homo sapiens
2.5.1.59 geranylgeranyltransferase type I
-
 Rattus norvegicus
2.5.1.59 GGTase-I
-
 Rattus norvegicus