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Literature summary extracted from

  • Anderton, M.C.; Bhakta, S.; Besra, G.S.; Jeavons, P.; Eltis, L.D.; Sim, E.
    Characterization of the putative operon containing arylamine N-acetyltransferase (nat) in Mycobacterium bovis BCG (2006), Mol. Microbiol., 59, 181-192.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.3.1.5 gene nat encoded in the nat operon, DNA and amio acid sequence determination and analysis, genetic structure, promoter consensus sequences, during in vitro growth all the genes in the putative nat operon are expressed, overview Mycobacterium tuberculosis variant bovis

Protein Variants

EC Number Protein Variants Comment Organism
2.3.1.5 additional information deletion of the nat gene causes an extended lag phase in strain BCG and a cell morphology associated with an altered pattern of cell wall mycolates, overview Mycobacterium tuberculosis variant bovis

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.13.11.39 3-chlorocatechol a suicide inhibitor of BphC that oxidizes the active site Fe(II) Mycobacterium tuberculosis variant bovis
2.3.1.5 2,3-Dihydroxybiphenyl the growth of strain BCG is retarded when the cultures are incubated either in the presence of 2,3-dihydroxybiphenyl on both solid and liquid media Mycobacterium tuberculosis variant bovis
2.3.1.5 3-chlorocatechol the growth of strain BCG is retarded when the cultures are incubated either in the presence of 3-chlorocatechol on both solid and liquid media Mycobacterium tuberculosis variant bovis

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.5 acetyl-CoA + an arylamine Mycobacterium tuberculosis variant bovis
-
 CoA + an N-acetylarylamine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.13.11.39 Mycobacterium tuberculosis variant bovis
-
-
-
2.3.1.5 Mycobacterium tuberculosis variant bovis
-
 gene nat
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.13.11.39 biphenyl-2,3-diol + O2
-
 Mycobacterium tuberculosis variant bovis 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate + H2O
-
 ?
2.3.1.5 acetyl-CoA + an arylamine
-
 Mycobacterium tuberculosis variant bovis CoA + an N-acetylarylamine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.13.11.39 2,3-dihydroxybiphenyl 1,2-dioxygenase
-
 Mycobacterium tuberculosis variant bovis
1.13.11.39 bphC5
-
 Mycobacterium tuberculosis variant bovis
2.3.1.5 NAT
-
 Mycobacterium tuberculosis variant bovis

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.3.1.5 7.5
-
 assay at Mycobacterium tuberculosis variant bovis

Cofactor

EC Number Cofactor Comment Organism Structure
2.3.1.5 acetyl-CoA
-
 Mycobacterium tuberculosis variant bovis