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Literature summary extracted from

  • Dawson-Scully, K.; Armstrong, G.A.; Kent, C.; Robertson, R.M.; Sokolowski, M.B.
    Natural variation in the thermotolerance of neural function and behavior due to a cGMP-dependent protein kinase (2007), PLoS ONE, 2, e773.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.11.12 8-bromo-cGMP PKG activator 8-bromo-cGMP abolishes thermoprotective effect of a prior heat shock Drosophila melanogaster
2.7.11.12 cGMP
-
Drosophila melanogaster

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.11.12 the enzyme is encoded by the foraging gene for which shows polymorphisms associated with the allelic variation in for Drosophila melanogaster

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.11.12 KT5823 a specific PKG inhibitor, PKG inhibition induces rapid thermotolerance of neural circuitry Drosophila melanogaster

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.11.12 Mg2+
-
Drosophila melanogaster

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.12 additional information Drosophila melanogaster reduced enzyme activity leads to increased thermotolerance of synaptic transmission at the larval neuromuscular junction, PKG and the for gene polymorphism associated with the allelic variation in for may provide populationswith natural variantion in heat stress tolerance, the for gene function in behaviour is conserved across most organisms, overview ?
-
?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.12 Drosophila melanogaster
-
gene for
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.12 larva
-
Drosophila melanogaster
-
2.7.11.12 muscle
-
Drosophila melanogaster
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.12 additional information reduced enzyme activity leads to increased thermotolerance of synaptic transmission at the larval neuromuscular junction, PKG and the for gene polymorphism associated with the allelic variation in for may provide populationswith natural variantion in heat stress tolerance, the for gene function in behaviour is conserved across most organisms, overview Drosophila melanogaster ?
-
?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.12 PKG
-
Drosophila melanogaster

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.11.12 ATP
-
Drosophila melanogaster