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Literature summary extracted from

  • Kamp, G.; Schmidt, H.; Stypa, H.; Feiden, S.; Mahling, C.; Wegener, G.
    Regulatory properties of 6-phosphofructokinase and control of glycolysis in boar spermatozoa (2007), Reproduction, 133, 29-40.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.1.11 AMP activates Sus scrofa
2.7.1.11 AMP at near-physiological substrate concentrations, PFK activity requires activators of which the combination of AMP and fructose 2,6-bisphosphate is most efficient as a result of synergistic effects Sus scrofa
2.7.1.11 D-fructose 2,6-bisphosphate activates Sus scrofa
2.7.1.11 fructose 2,6-bisphosphate at near-physiological substrate concentrations, PFK activity requires activators of which the combination of AMP and fructose 2,6-bisphosphate is most efficient as a result of synergistic effects Sus scrofa

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.1.11 ATP at physiological concentration; at physiological pH, the enzyme is allosterically inhibited by near-physiological concentrations of its co-substrate ATP, which induces cooperativity, i.e. reduces the affinity for the substrate fructose 6-phosphate. Inhibition by ATP is reinforced by citrate and H+ Sus scrofa

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.1.11 acrosome
-
 Sus scrofa
-
-
2.7.1.11 flagellum
-
 Sus scrofa
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.11 additional information Sus scrofa 6-phosphofructokinase is the most important element for control of glycolytic flux ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.11 Sus scrofa
-
-
-
2.7.1.11 Sus scrofa
-
 boar
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.1.11
-
 Sus scrofa

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.11 spermatozoon localized in the mid-piece and principal piece of the flagellum as well as in the acrosomal area at the top of the head and in the cytoplasmic droplets released from the mid-piece after ejaculation Sus scrofa
-
2.7.1.11 spermatozoon PFK shows no tight binding to sperm structures. It can readily be extracted from ejaculated boar spermatozoa by sonication. PFK is localized in the mid-piece and principal piece of the flagellum as well as in the acrosomal area at the top of the head and in the cytoplasmic droplets released from the mid-piece after ejaculation Sus scrofa
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.11 additional information 6-phosphofructokinase is the most important element for control of glycolytic flux Sus scrofa ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.1.11 PFK
-
 Sus scrofa

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.7.1.11 8
-
 above pH 8, the enzyme loses all its regulatory properties and shows maximal activity Sus scrofa
2.7.1.11 8
-
 above pH 8, PFK lost all its regulatory properties and showed maximum activity Sus scrofa