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Literature summary extracted from

  • Patel, R.T.; Soulages, J.L.; Arrese, E.L.
    Adipokinetic hormone-induced mobilization of fat body triglyceride stores in Manduca sexta: role of TG-lipase and lipid droplets (2006), Arch. Insect Biochem. Physiol., 63, 73-81.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.1.1.3 additional information protein kinase A phosphorylates and activates the TG-lipase substrate, the lipid droplets, PKA also phosphorylates the lipase, but does not directly activate it, overview, the changes induced by adipokinetic hormone on the lipid droplets contribute with an approximately 2fold increase to the overall rate of lipolysis Manduca sexta

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.1.3 cytosol
-
 Manduca sexta 5829
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.1.3 triacylglycerol + H2O Manduca sexta the enzyme is involved in adipokinetic hormone-induced mobilization of fat body triglyceride stores in Manduca sexta, protein kinase A phosphorylates and activates the TG-lipase substrate, the lipid droplets, protein kinase A also phosphorylates the lipase, but does not directly activate it, overview diacylglycerol + a carboxylate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.3 Manduca sexta
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
3.1.1.3 phosphoprotein protein kinase A phosphorylates the TG-lipase, while it does not directly activate it, but activates the lipid droplet substrate, also increasing enzyme activity that way, overview Manduca sexta

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.1.3 fat body
-
 Manduca sexta
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.1.1.3 additional information
-
-
 Manduca sexta

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.1.3 triacylglycerol + H2O
-
 Manduca sexta diacylglycerol + a carboxylate
-
 ?
3.1.1.3 triacylglycerol + H2O the enzyme is involved in adipokinetic hormone-induced mobilization of fat body triglyceride stores in Manduca sexta, protein kinase A phosphorylates and activates the TG-lipase substrate, the lipid droplets, protein kinase A also phosphorylates the lipase, but does not directly activate it, overview Manduca sexta diacylglycerol + a carboxylate
-
 ?
3.1.1.3 triolein + H2O
-
 Manduca sexta diolein + oleate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.1.3 TG-lipase
-
 Manduca sexta

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.1.1.3 37
-
 assay at Manduca sexta

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.1.1.3 7.9
-
 assay at Manduca sexta