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Literature summary extracted from

  • Deaton, D.N.; Gao, E.N.; Graham, K.P.; Gross, J.W.; Miller, A.B.; Strelow, J.M.
    Thiol-based angiotensin-converting enzyme 2 inhibitors: P1 modifications for the exploration of the S1 subsite (2008), Bioorg. Med. Chem. Lett., 18, 732-737.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.15.1 (2S)-2-[[(2S)-2-mercapto-3-methylpentanoyl]amino]-3-(2-naphthyl)propanoic acid
-
 Homo sapiens
3.4.15.1 (2S)-3-biphenyl-2-yl-2-[[(2S)-3-methyl-2-sulfanylpentanoyl]amino]propanoic acid
-
 Homo sapiens
3.4.15.1 (2S)-3-biphenyl-3-yl-2-[[(2S)-3-methyl-2-sulfanylpentanoyl]amino]propanoic acid
-
 Homo sapiens
3.4.15.1 (2S)-3-biphenyl-4-yl-2-[(2-mercapto-2-methylpropanoyl)amino]propanoic acid
-
 Homo sapiens
3.4.15.1 (2S)-3-biphenyl-4-yl-2-[(mercaptoacetyl)amino]propanoic acid
-
 Homo sapiens
3.4.15.1 (2S)-3-biphenyl-4-yl-2-[[(2S)-2-mercaptobutanoyl]amino]propanoic acid
-
 Homo sapiens
3.4.15.1 (2S)-3-biphenyl-4-yl-2-[[(2S)-2-mercaptopropanoyl]amino]propanoic acid
-
 Homo sapiens
3.4.15.1 (2S)-3-biphenyl-4-yl-2-[[(2S)-3-methyl-2-sulfanylpentanoyl]amino]propanoic acid
-
 Homo sapiens
3.4.15.1 2-(benzyloxy)-N-[(2S)-3-methyl-2-sulfanylpentanoyl]-L-phenylalanine
-
 Homo sapiens
3.4.15.1 3-(benzyloxy)-N-[(2S)-3-methyl-2-sulfanylpentanoyl]-L-phenylalanine
-
 Homo sapiens
3.4.15.1 N-[(2S)-3-methyl-2-sulfanylpentanoyl]-2-phenoxy-L-phenylalanine
-
 Homo sapiens
3.4.15.1 N-[(2S)-3-methyl-2-sulfanylpentanoyl]-3-phenoxy-L-phenylalanine
-
 Homo sapiens
3.4.15.1 N-[(2S)-3-methyl-2-sulfanylpentanoyl]-O-phenyl-L-tyrosine
-
 Homo sapiens
3.4.15.1 N-[(2S)-3-methyl-2-sulfanylpentanoyl]-O-[4-(trifluoromethyl)benzyl]-L-tyrosine
-
 Homo sapiens
3.4.15.1 O-(2,4-difluorobenzyl)-N-[(2S)-3-methyl-2-sulfanylpentanoyl]-L-tyrosine
-
 Homo sapiens
3.4.15.1 O-(3,4-difluorobenzyl)-N-[(2S)-3-methyl-2-sulfanylpentanoyl]-L-tyrosine
-
 Homo sapiens
3.4.15.1 O-(4-fluorobenzyl)-N-[(2S)-3-methyl-2-sulfanylpentanoyl]-L-tyrosine
-
 Homo sapiens
3.4.15.1 O-benzyl-N-[(2S)-3-methyl-2-sulfanylpentanoyl]-L-tyrosine
-
 Homo sapiens
3.4.15.1 [[(2S)-2-mercapto-3-methylpentanoyl]amino]acetic acid
-
 Homo sapiens
3.4.17.23 (2S)-3-(biphenyl-4-yl)-2-((3S)-2-mercapto-3-methylpentanamido)propanoic acid
-
 Homo sapiens
3.4.17.23 (2S)-3-biphenyl-4-yl-2-[(2-methyl-2-sulfanylpropanoyl)amino]propanoic acid
-
 Homo sapiens
3.4.17.23 (2S)-3-biphenyl-4-yl-2-[(2-sulfanylpropanoyl)amino]propanoic acid
-
 Homo sapiens
3.4.17.23 (2S)-3-biphenyl-4-yl-2-[(sulfanylacetyl)amino]propanoic acid
-
 Homo sapiens
3.4.17.23 (2S)-3-biphenyl-4-yl-2-[[(2R)-2-sulfanylbutanoyl]amino]propanoic acid
-
 Homo sapiens
3.4.17.23 (2S)-3-biphenyl-4-yl-2-[[(2R)-3-methyl-2-sulfanylbutanoyl]amino]propanoic acid
-
 Homo sapiens
3.4.17.23 (2S)-3-biphenyl-4-yl-2-[[(2R)-3-phenyl-2-sulfanylpropanoyl]amino]propanoic acid
-
 Homo sapiens
3.4.17.23 (2S)-3-biphenyl-4-yl-2-[[(2S)-2-phenyl-2-sulfanylacetyl]amino]propanoic acid
-
 Homo sapiens
3.4.17.23 (2S)-3-biphenyl-4-yl-2-[[(2S)-2-sulfanylhexanoyl]amino]propanoic acid
-
 Homo sapiens
3.4.17.23 (2S)-3-biphenyl-4-yl-2-[[(2S)-3-phenyl-2-sulfanylpropanoyl]amino]propanoic acid
-
 Homo sapiens
3.4.17.23 (2S)-3-biphenyl-4-yl-2-[[cyclobutyl(sulfanyl)acetyl]amino]propanoic acid
-
 Homo sapiens
3.4.17.23 (S)-3-(biphenyl-4-yl)-2-((2R,3R)-2-mercapto-3-methylpentanamido)propanoic acid
-
 Homo sapiens
3.4.17.23 (S)-3-(biphenyl-4-yl)-2-((R)-2-cyclohexyl-2-mercaptoacetamido)propanoic acid
-
 Homo sapiens
3.4.17.23 (S)-3-(biphenyl-4-yl)-2-((R)-2-cyclopentyl-2-mercaptoacetamido)propanoic acid
-
 Homo sapiens
3.4.17.23 (S)-3-(biphenyl-4-yl)-2-((R)-2-mercapto-3-(naphthalen-2-yl)propanamido)propanoic acid
-
 Homo sapiens
3.4.17.23 (S)-3-(biphenyl-4-yl)-2-((R)-2-mercapto-4,4-dimethylpentanamido)propanoic acid
-
 Homo sapiens
3.4.17.23 (S)-3-(biphenyl-4-yl)-2-((R)-2-mercapto-4-methylpentanamido)propanoic acid
-
 Homo sapiens
3.4.17.23 (S)-3-(biphenyl-4-yl)-2-((R)-2-mercapto-4-phenylbutanamido)propanoic acid
-
 Homo sapiens
3.4.17.23 (S)-3-(biphenyl-4-yl)-2-((R)-3-cyclohexyl-2-mercaptopropanamido)propanoic acid
-
 Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.4.15.1 Homo sapiens
-
-
-
3.4.15.1 Homo sapiens Q9BYF1
-
-
3.4.17.23 Homo sapiens Q9BYF1
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.15.1 MCA-Ala-Ser-Asp-Lys-Dap(DNP)-OH + H2O angiotensin-converting enzyme Homo sapiens ?
-
 ?
3.4.15.1 MCA-Tyr-Val-Ala-Asp-Ala-Pro-Lys(DNP)-OH + H2O angiotensin-converting enzyme 2 Homo sapiens ?
-
 ?
3.4.17.23 (7-methoxycoumarin-4-yl)-acetyl-Tyr-Val-Ala-Asp-Ala-Pro-Lys(2,4-dinitrophenyl)-OH + H2O
-
 Homo sapiens (7-methoxycoumarin-4-yl)-acetyl-Tyr-Val-Ala-Asp-Ala-Pro + N6-(2,4-dinitrophenyl)-L-Lys
-
 ?
3.4.17.23 angiotensin II + H2O
-
 Homo sapiens angiotensin-(1-7) + Phe
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.15.1 ACE
-
 Homo sapiens
3.4.15.1 ACE2
-
 Homo sapiens
3.4.15.1 angiotensin-converting enzyme
-
 Homo sapiens
3.4.15.1 angiotensin-converting enzyme 2
-
 Homo sapiens
3.4.17.23 ACE2
-
 Homo sapiens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
3.4.15.1 0.0000014
-
 O-benzyl-N-[(2S)-3-methyl-2-sulfanylpentanoyl]-L-tyrosine pH 7.5, angiotensin-converting enzyme 2 Homo sapiens
3.4.15.1 0.0000014
-
 (2S)-3-biphenyl-4-yl-2-[[(2S)-2-mercaptobutanoyl]amino]propanoic acid pH 7.5, angiotensin-converting enzyme 2 Homo sapiens
3.4.15.1 0.0000015
-
 (2S)-3-biphenyl-2-yl-2-[[(2S)-3-methyl-2-sulfanylpentanoyl]amino]propanoic acid pH 7.5, angiotensin-converting enzyme 2 Homo sapiens
3.4.15.1 0.0000015
-
 (2S)-3-biphenyl-3-yl-2-[[(2S)-3-methyl-2-sulfanylpentanoyl]amino]propanoic acid pH 7.5, angiotensin-converting enzyme 2 Homo sapiens
3.4.15.1 0.0000016
-
 N-[(2S)-3-methyl-2-sulfanylpentanoyl]-2-phenoxy-L-phenylalanine pH 7.5, angiotensin-converting enzyme 2 Homo sapiens
3.4.15.1 0.0000018
-
 (2S)-2-[[(2S)-2-mercapto-3-methylpentanoyl]amino]-3-(2-naphthyl)propanoic acid pH 7.5, angiotensin-converting enzyme 2 Homo sapiens
3.4.15.1 0.0000018
-
 N-[(2S)-3-methyl-2-sulfanylpentanoyl]-O-phenyl-L-tyrosine pH 7.5, angiotensin-converting enzyme 2 Homo sapiens
3.4.15.1 0.0000024
-
 N-[(2S)-3-methyl-2-sulfanylpentanoyl]-3-phenoxy-L-phenylalanine pH 7.5, angiotensin-converting enzyme 2 Homo sapiens
3.4.15.1 0.0000032
-
 O-benzyl-N-[(2S)-3-methyl-2-sulfanylpentanoyl]-L-tyrosine pH 7.5, angiotensin-converting enzyme Homo sapiens
3.4.15.1 0.0000069
-
 (2S)-3-biphenyl-4-yl-2-[[(2S)-2-mercaptopropanoyl]amino]propanoic acid pH 7.5, angiotensin-converting enzyme 2 Homo sapiens
3.4.15.1 0.0000071
-
 O-(4-fluorobenzyl)-N-[(2S)-3-methyl-2-sulfanylpentanoyl]-L-tyrosine pH 7.5, angiotensin-converting enzyme 2 Homo sapiens
3.4.15.1 0.0000086
-
 (2S)-3-biphenyl-4-yl-2-[[(2S)-2-mercaptobutanoyl]amino]propanoic acid pH 7.5, angiotensin-converting enzyme Homo sapiens
3.4.15.1 0.0000093
-
 (2S)-2-[[(2S)-2-mercapto-3-methylpentanoyl]amino]-3-(2-naphthyl)propanoic acid pH 7.5, angiotensin-converting enzyme Homo sapiens
3.4.15.1 0.000016
-
 (2S)-3-biphenyl-4-yl-2-[(mercaptoacetyl)amino]propanoic acid pH 7.5, angiotensin-converting enzyme Homo sapiens
3.4.15.1 0.000021
-
 (2S)-3-biphenyl-4-yl-2-[[(2S)-2-mercaptopropanoyl]amino]propanoic acid pH 7.5, angiotensin-converting enzyme Homo sapiens
3.4.15.1 0.00003
-
 (2S)-3-biphenyl-4-yl-2-[[(2S)-3-methyl-2-sulfanylpentanoyl]amino]propanoic acid pH 7.5, angiotensin-converting enzyme Homo sapiens
3.4.15.1 0.000065
-
 2-(benzyloxy)-N-[(2S)-3-methyl-2-sulfanylpentanoyl]-L-phenylalanine pH, angiotensin-converting enzyme 2 Homo sapiens
3.4.15.1 0.000084
-
 3-(benzyloxy)-N-[(2S)-3-methyl-2-sulfanylpentanoyl]-L-phenylalanine pH 7.5, angiotensin-converting enzyme 2 Homo sapiens
3.4.15.1 0.000086
-
 (2S)-3-biphenyl-4-yl-2-[[(2S)-3-methyl-2-sulfanylpentanoyl]amino]propanoic acid pH 7.5, angiotensin-converting enzyme 2 Homo sapiens
3.4.15.1 0.000093
-
 N-[(2S)-3-methyl-2-sulfanylpentanoyl]-O-[4-(trifluoromethyl)benzyl]-L-tyrosine pH 7.5, angiotensin-converting enzyme Homo sapiens
3.4.15.1 0.0002
-
 (2S)-3-biphenyl-2-yl-2-[[(2S)-3-methyl-2-sulfanylpentanoyl]amino]propanoic acid pH 7.5, angiotensin-converting enzyme Homo sapiens
3.4.15.1 0.0002
-
 N-[(2S)-3-methyl-2-sulfanylpentanoyl]-2-phenoxy-L-phenylalanine pH 7.5, angiotensin-converting enzyme Homo sapiens
3.4.15.1 0.00021
-
 O-(3,4-difluorobenzyl)-N-[(2S)-3-methyl-2-sulfanylpentanoyl]-L-tyrosine pH 7.5, angiotensin-converting enzyme Homo sapiens
3.4.15.1 0.00032
-
 (2S)-3-biphenyl-4-yl-2-[(mercaptoacetyl)amino]propanoic acid pH 7.5, angiotensin-converting enzyme 2 Homo sapiens
3.4.15.1 0.00042
-
 O-(2,4-difluorobenzyl)-N-[(2S)-3-methyl-2-sulfanylpentanoyl]-L-tyrosine pH 7.5, angiotensin-converting enzyme 2 Homo sapiens
3.4.15.1 0.00049
-
 (2S)-3-biphenyl-3-yl-2-[[(2S)-3-methyl-2-sulfanylpentanoyl]amino]propanoic acid pH 7.5, angiotensin-converting enzyme Homo sapiens
3.4.15.1 0.00052
-
 [[(2S)-2-mercapto-3-methylpentanoyl]amino]acetic acid pH 7.5, angiotensin-converting enzyme Homo sapiens
3.4.15.1 0.00055
-
 O-(3,4-difluorobenzyl)-N-[(2S)-3-methyl-2-sulfanylpentanoyl]-L-tyrosine pH 7.5, angiotensin-converting enzyme 2 Homo sapiens
3.4.15.1 0.00062
-
 N-[(2S)-3-methyl-2-sulfanylpentanoyl]-3-phenoxy-L-phenylalanine pH 7.5, angiotensin-converting enzyme Homo sapiens
3.4.15.1 0.0007
-
 N-[(2S)-3-methyl-2-sulfanylpentanoyl]-O-phenyl-L-tyrosine pH 7.5, angiotensin-converting enzyme Homo sapiens
3.4.15.1 0.00084
-
 O-(2,4-difluorobenzyl)-N-[(2S)-3-methyl-2-sulfanylpentanoyl]-L-tyrosine pH 7.5, angiotensin-converting enzyme Homo sapiens
3.4.15.1 0.00086
-
 N-[(2S)-3-methyl-2-sulfanylpentanoyl]-O-[4-(trifluoromethyl)benzyl]-L-tyrosine pH 7.5, angiotensin-converting enzyme 2 Homo sapiens
3.4.15.1 0.0014
-
 [[(2S)-2-mercapto-3-methylpentanoyl]amino]acetic acid pH 7.5, angiotensin-converting enzyme 2 Homo sapiens
3.4.15.1 0.0023
-
 (2S)-3-biphenyl-4-yl-2-[(2-mercapto-2-methylpropanoyl)amino]propanoic acid pH 7.5, angiotensin-converting enzyme 2 Homo sapiens
3.4.15.1 0.0027
-
 O-(4-fluorobenzyl)-N-[(2S)-3-methyl-2-sulfanylpentanoyl]-L-tyrosine pH 7.5, angiotensin-converting enzymepotent and long-acting DPP-IV inhibitor and effective with single daily dosing Homo sapiens
3.4.15.1 0.0034
-
 (2S)-3-biphenyl-4-yl-2-[(2-mercapto-2-methylpropanoyl)amino]propanoic acid pH 7.5, angiotensin-converting enzyme Homo sapiens
3.4.15.1 0.013
-
 2-(benzyloxy)-N-[(2S)-3-methyl-2-sulfanylpentanoyl]-L-phenylalanine pH, angiotensin-converting enzyme Homo sapiens
3.4.17.23 0.0000014
-
 (2S)-3-biphenyl-4-yl-2-[[(2R)-2-sulfanylbutanoyl]amino]propanoic acid apparent value, in (7-methoxycoumarin-4-yl)-acetyl-Tyr-Val-Ala-Asp-Ala-Pro-Lys(2,4-dinitrophenyl)-OH as substrate in 0.001 mM Zn(OAc)2, 0.1 mM TCEP, 50 mM HEPES, 0.3 mM CHAPS, and 300 mM NaCl, at pH 7.5 Homo sapiens
3.4.17.23 0.0000014
-
 (S)-3-(biphenyl-4-yl)-2-((R)-2-mercapto-4-methylpentanamido)propanoic acid apparent value, in (7-methoxycoumarin-4-yl)-acetyl-Tyr-Val-Ala-Asp-Ala-Pro-Lys(2,4-dinitrophenyl)-OH as substrate in 0.001 mM Zn(OAc)2, 0.1 mM TCEP, 50 mM HEPES, 0.3 mM CHAPS, and 300 mM NaCl, at pH 7.5 Homo sapiens
3.4.17.23 0.0000015
-
 (2S)-3-(biphenyl-4-yl)-2-((3S)-2-mercapto-3-methylpentanamido)propanoic acid apparent value, in (7-methoxycoumarin-4-yl)-acetyl-Tyr-Val-Ala-Asp-Ala-Pro-Lys(2,4-dinitrophenyl)-OH as substrate in 0.001 mM Zn(OAc)2, 0.1 mM TCEP, 50 mM HEPES, 0.3 mM CHAPS, and 300 mM NaCl, at pH 7.5 Homo sapiens
3.4.17.23 0.0000015
-
 (2S)-3-biphenyl-4-yl-2-[[(2R)-3-methyl-2-sulfanylbutanoyl]amino]propanoic acid apparent value, in (7-methoxycoumarin-4-yl)-acetyl-Tyr-Val-Ala-Asp-Ala-Pro-Lys(2,4-dinitrophenyl)-OH as substrate in 0.001 mM Zn(OAc)2, 0.1 mM TCEP, 50 mM HEPES, 0.3 mM CHAPS, and 300 mM NaCl, at pH 7.5 Homo sapiens
3.4.17.23 0.0000016
-
 (S)-3-(biphenyl-4-yl)-2-((2R,3R)-2-mercapto-3-methylpentanamido)propanoic acid apparent value, in (7-methoxycoumarin-4-yl)-acetyl-Tyr-Val-Ala-Asp-Ala-Pro-Lys(2,4-dinitrophenyl)-OH as substrate in 0.001 mM Zn(OAc)2, 0.1 mM TCEP, 50 mM HEPES, 0.3 mM CHAPS, and 300 mM NaCl, at pH 7.5 Homo sapiens
3.4.17.23 0.0000018
-
 (2S)-3-biphenyl-4-yl-2-[[(2S)-2-sulfanylhexanoyl]amino]propanoic acid apparent value, in (7-methoxycoumarin-4-yl)-acetyl-Tyr-Val-Ala-Asp-Ala-Pro-Lys(2,4-dinitrophenyl)-OH as substrate in 0.001 mM Zn(OAc)2, 0.1 mM TCEP, 50 mM HEPES, 0.3 mM CHAPS, and 300 mM NaCl, at pH 7.5 Homo sapiens
3.4.17.23 0.0000018
-
 (S)-3-(biphenyl-4-yl)-2-((R)-2-cyclopentyl-2-mercaptoacetamido)propanoic acid apparent value, in (7-methoxycoumarin-4-yl)-acetyl-Tyr-Val-Ala-Asp-Ala-Pro-Lys(2,4-dinitrophenyl)-OH as substrate in 0.001 mM Zn(OAc)2, 0.1 mM TCEP, 50 mM HEPES, 0.3 mM CHAPS, and 300 mM NaCl, at pH 7.5 Homo sapiens
3.4.17.23 0.0000024
-
 (2S)-3-biphenyl-4-yl-2-[[cyclobutyl(sulfanyl)acetyl]amino]propanoic acid apparent value, in (7-methoxycoumarin-4-yl)-acetyl-Tyr-Val-Ala-Asp-Ala-Pro-Lys(2,4-dinitrophenyl)-OH as substrate in 0.001 mM Zn(OAc)2, 0.1 mM TCEP, 50 mM HEPES, 0.3 mM CHAPS, and 300 mM NaCl, at pH 7.5 Homo sapiens
3.4.17.23 0.0000069
-
 (2S)-3-biphenyl-4-yl-2-[(2-sulfanylpropanoyl)amino]propanoic acid apparent value, in (7-methoxycoumarin-4-yl)-acetyl-Tyr-Val-Ala-Asp-Ala-Pro-Lys(2,4-dinitrophenyl)-OH as substrate in 0.001 mM Zn(OAc)2, 0.1 mM TCEP, 50 mM HEPES, 0.3 mM CHAPS, and 300 mM NaCl, at pH 7.5 Homo sapiens
3.4.17.23 0.0000071
-
 (S)-3-(biphenyl-4-yl)-2-((R)-2-mercapto-4,4-dimethylpentanamido)propanoic acid apparent value, in (7-methoxycoumarin-4-yl)-acetyl-Tyr-Val-Ala-Asp-Ala-Pro-Lys(2,4-dinitrophenyl)-OH as substrate in 0.001 mM Zn(OAc)2, 0.1 mM TCEP, 50 mM HEPES, 0.3 mM CHAPS, and 300 mM NaCl, at pH 7.5 Homo sapiens
3.4.17.23 0.000065
-
 (S)-3-(biphenyl-4-yl)-2-((R)-2-cyclohexyl-2-mercaptoacetamido)propanoic acid apparent value, in (7-methoxycoumarin-4-yl)-acetyl-Tyr-Val-Ala-Asp-Ala-Pro-Lys(2,4-dinitrophenyl)-OH as substrate in 0.001 mM Zn(OAc)2, 0.1 mM TCEP, 50 mM HEPES, 0.3 mM CHAPS, and 300 mM NaCl, at pH 7.5 Homo sapiens
3.4.17.23 0.000084
-
 (2S)-3-biphenyl-4-yl-2-[[(2S)-2-phenyl-2-sulfanylacetyl]amino]propanoic acid apparent value, in (7-methoxycoumarin-4-yl)-acetyl-Tyr-Val-Ala-Asp-Ala-Pro-Lys(2,4-dinitrophenyl)-OH as substrate in 0.001 mM Zn(OAc)2, 0.1 mM TCEP, 50 mM HEPES, 0.3 mM CHAPS, and 300 mM NaCl, at pH 7.5 Homo sapiens
3.4.17.23 0.000086
-
 (2S)-3-biphenyl-4-yl-2-[[(2R)-3-phenyl-2-sulfanylpropanoyl]amino]propanoic acid apparent value, in (7-methoxycoumarin-4-yl)-acetyl-Tyr-Val-Ala-Asp-Ala-Pro-Lys(2,4-dinitrophenyl)-OH as substrate in 0.001 mM Zn(OAc)2, 0.1 mM TCEP, 50 mM HEPES, 0.3 mM CHAPS, and 300 mM NaCl, at pH 7.5 Homo sapiens
3.4.17.23 0.00032
-
 (2S)-3-biphenyl-4-yl-2-[(sulfanylacetyl)amino]propanoic acid apparent value, in (7-methoxycoumarin-4-yl)-acetyl-Tyr-Val-Ala-Asp-Ala-Pro-Lys(2,4-dinitrophenyl)-OH as substrate in 0.001 mM Zn(OAc)2, 0.1 mM TCEP, 50 mM HEPES, 0.3 mM CHAPS, and 300 mM NaCl, at pH 7.5 Homo sapiens
3.4.17.23 0.00042
-
 (S)-3-(biphenyl-4-yl)-2-((R)-3-cyclohexyl-2-mercaptopropanamido)propanoic acid apparent value, in (7-methoxycoumarin-4-yl)-acetyl-Tyr-Val-Ala-Asp-Ala-Pro-Lys(2,4-dinitrophenyl)-OH as substrate in 0.001 mM Zn(OAc)2, 0.1 mM TCEP, 50 mM HEPES, 0.3 mM CHAPS, and 300 mM NaCl, at pH 7.5 Homo sapiens
3.4.17.23 0.00055
-
 (S)-3-(biphenyl-4-yl)-2-((R)-2-mercapto-3-(naphthalen-2-yl)propanamido)propanoic acid apparent value, in (7-methoxycoumarin-4-yl)-acetyl-Tyr-Val-Ala-Asp-Ala-Pro-Lys(2,4-dinitrophenyl)-OH as substrate in 0.001 mM Zn(OAc)2, 0.1 mM TCEP, 50 mM HEPES, 0.3 mM CHAPS, and 300 mM NaCl, at pH 7.5 Homo sapiens
3.4.17.23 0.00086
-
 (S)-3-(biphenyl-4-yl)-2-((R)-2-mercapto-4-phenylbutanamido)propanoic acid apparent value, in (7-methoxycoumarin-4-yl)-acetyl-Tyr-Val-Ala-Asp-Ala-Pro-Lys(2,4-dinitrophenyl)-OH as substrate in 0.001 mM Zn(OAc)2, 0.1 mM TCEP, 50 mM HEPES, 0.3 mM CHAPS, and 300 mM NaCl, at pH 7.5 Homo sapiens
3.4.17.23 0.0014
-
 (2S)-3-biphenyl-4-yl-2-[[(2S)-3-phenyl-2-sulfanylpropanoyl]amino]propanoic acid apparent value, in (7-methoxycoumarin-4-yl)-acetyl-Tyr-Val-Ala-Asp-Ala-Pro-Lys(2,4-dinitrophenyl)-OH as substrate in 0.001 mM Zn(OAc)2, 0.1 mM TCEP, 50 mM HEPES, 0.3 mM CHAPS, and 300 mM NaCl, at pH 7.5 Homo sapiens
3.4.17.23 0.0023
-
 (2S)-3-biphenyl-4-yl-2-[(2-methyl-2-sulfanylpropanoyl)amino]propanoic acid apparent value, in (7-methoxycoumarin-4-yl)-acetyl-Tyr-Val-Ala-Asp-Ala-Pro-Lys(2,4-dinitrophenyl)-OH as substrate in 0.001 mM Zn(OAc)2, 0.1 mM TCEP, 50 mM HEPES, 0.3 mM CHAPS, and 300 mM NaCl, at pH 7.5 Homo sapiens