EC Number | Application | Comment | Organism |
---|---|---|---|
3.4.21.118 | additional information | the type II form (longer form) of neuropsin is only expressed in the central nervous system of human. Its origin is less than 5 million years ago. The occurrence of the type II form in human is caused by a human-specific mutation near the novel splicing site. It persists a molecular mechanism for the creation of novel proteins through alternative splicing in the central nervous system during human evolution. Potential importance of the creation of novel splicing forms in the central nervous system in the emergence of human cognition | Homo sapiens |
EC Number | Protein Variants | Comment | Organism |
---|---|---|---|
3.4.21.118 | additional information | a human-specific T to A mutation triggers the change of splicing pattern. Mutation is not only necessary but also sufficient for type II expression | Homo sapiens |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.4.21.118 | Homo sapiens | O60259 | - |
- |
3.4.21.118 | Macaca mulatta | Q5V9S7 | - |
- |
3.4.21.118 | Pan troglodytes | Q5V9U8 | - |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
3.4.21.118 | brain | - |
Homo sapiens | - |
3.4.21.118 | brain | - |
Pan troglodytes | - |
3.4.21.118 | brain | - |
Macaca mulatta | - |
3.4.21.118 | central nervous system | - |
Homo sapiens | - |
3.4.21.118 | placenta | - |
Homo sapiens | - |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
3.4.21.118 | neuropsin | - |
Homo sapiens |
3.4.21.118 | neuropsin | - |
Pan troglodytes |
3.4.21.118 | neuropsin | - |
Macaca mulatta |
3.4.21.118 | type I neuropsin | - |
Pan troglodytes |
3.4.21.118 | type I neuropsin | - |
Macaca mulatta |
3.4.21.118 | type II neuropsin | - |
Homo sapiens |