Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Lu, Z.X.; Peng, J.; Su, B.
    A human-specific mutation leads to the origin of a novel splice form of neuropsin (KLK8), a gene involved in learning and memory (2007), Hum. Mutat., 28, 978-984.
    View publication on PubMed

Application

EC Number Application Comment Organism
3.4.21.118 additional information the type II form (longer form) of neuropsin is only expressed in the central nervous system of human. Its origin is less than 5 million years ago. The occurrence of the type II form in human is caused by a human-specific mutation near the novel splicing site. It persists a molecular mechanism for the creation of novel proteins through alternative splicing in the central nervous system during human evolution. Potential importance of the creation of novel splicing forms in the central nervous system in the emergence of human cognition Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
3.4.21.118 additional information a human-specific T to A mutation triggers the change of splicing pattern. Mutation is not only necessary but also sufficient for type II expression Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.118 Homo sapiens O60259
-
-
3.4.21.118 Macaca mulatta Q5V9S7
-
-
3.4.21.118 Pan troglodytes Q5V9U8
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.21.118 brain
-
Homo sapiens
-
3.4.21.118 brain
-
Pan troglodytes
-
3.4.21.118 brain
-
Macaca mulatta
-
3.4.21.118 central nervous system
-
Homo sapiens
-
3.4.21.118 placenta
-
Homo sapiens
-

Synonyms

EC Number Synonyms Comment Organism
3.4.21.118 neuropsin
-
Homo sapiens
3.4.21.118 neuropsin
-
Pan troglodytes
3.4.21.118 neuropsin
-
Macaca mulatta
3.4.21.118 type I neuropsin
-
Pan troglodytes
3.4.21.118 type I neuropsin
-
Macaca mulatta
3.4.21.118 type II neuropsin
-
Homo sapiens