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Literature summary extracted from

  • Mores, A.; Matziari, M.; Beau, F.; Cuniasse, P.; Yiotakis, A.; Dive, V.
    Development of potent and selective phosphinic peptide inhibitors of angiotensin-converting enzyme 2 (2008), J. Med. Chem., 51, 2216-2226.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.17.23 2-benzyl-3-(hydroxy-pyrrolidin-2-yl-phosphinoyl)-propionic acid
-
Homo sapiens
3.4.17.23 2-benzyl-3-[(1-benzyloxycarbonylamino-2-phenyl-ethyl)-hydroxy-phosphinoyl]-propionic acid
-
Homo sapiens
3.4.17.23 2-benzyl-3-[(1-benzyloxycarbonylamino-3-methyl-butyl)-hydroxy-phosphinoyl]-propionic acid
-
Homo sapiens
3.4.17.23 2-benzyl-3-[(1-benzyloxycarbonylamino-ethyl)-hydroxy-phosphinoyl]-propionic acid
-
Homo sapiens
3.4.17.23 2-[(2-carboxy-3-phenyl-propyl)-hydroxy-phosphinoyl]-pyrrolidine-1-carboxylic acid benzyl ester
-
Homo sapiens
3.4.17.23 2-[(2-carboxy-4-methyl-pentyl)-hydroxy-phosphinoyl]-pyrrolidine-1-carboxylic acid benzyl ester
-
Homo sapiens
3.4.17.23 2-[(2-carboxy-propyl)-hydroxy-phosphinoyl]-pyrrolidine-1-carboxylic acid benzyl ester
-
Homo sapiens
3.4.17.23 3-([1-[2-acetylamino-3-(1H-imidazol-4-yl)-propionylamino]-3-methyl-butyl]-hydroxy-phosphinoyl)-2-(3-phenyl-isoxazol-5-ylmethyl)-propionic acid
-
Homo sapiens
3.4.17.23 3-([1-[2-acetylamino-3-(1H-imidazol-4-yl)-propionylamino]-3-methyl-butyl]-hydroxy-phosphinoyl)-2-benzyl-propionic acid
-
Homo sapiens
3.4.17.23 3-([1-[2-acetylamino-3-(1H-imidazol-4-yl)-propionyl]-pyrrolidin-2-yl]-hydroxy-phosphinoyl)-2-(3-phenyl-isoxazol-5-ylmethyl)-propionic acid
-
Homo sapiens
3.4.17.23 3-([1-[2-acetylamino-3-(1H-imidazol-4-yl)-propionyl]-pyrrolidin-2-yl]-hydroxy-phosphinoyl)-2-benzyl-propionic acid
-
Homo sapiens
3.4.17.23 3-([1-[2-acetylamino-3-(4-hydroxy-phenyl)-propionyl]-pyrrolidin-2-yl]-hydroxy-phosphinoyl)-2-benzyl-propionic acid
-
Homo sapiens
3.4.17.23 3-[(1-amino-2-phenyl-ethyl)-hydroxy-phosphinoyl]-2-benzylpropionic acid
-
Homo sapiens
3.4.17.23 3-[(1-amino-3-methyl-butyl)-hydroxy-phosphinoyl]-2-benzylpropionic acid
-
Homo sapiens
3.4.17.23 3-[(1-amino-ethyl)-hydroxy-phosphinoyl]-2-benzyl-propionic acid
-
Homo sapiens
3.4.17.23 3-[[1-(2-acetylamino-3-methyl-butyryl)-pyrrolidin-2-yl]-hydroxy-phosphinoyl]-2-benzyl-propionic acid
-
Homo sapiens
3.4.17.23 3-[[1-(2-acetylamino-3-phenyl-propionyl)-pyrrolidin-2-yl]-hydroxy-phosphinoyl]-2-benzyl-propionic acid
-
Homo sapiens
3.4.17.23 3-[[1-(2-acetylamino-4-methyl-pentanoyl)-pyrrolidin-2-yl]-hydroxy-phosphinoyl]-2-(3-phenyl-isoxazol-5-ylmethyl)-propionic acid
-
Homo sapiens
3.4.17.23 3-[[1-(2-acetylamino-4-methyl-pentanoyl)-pyrrolidin-2-yl]-hydroxy-phosphinoyl]-2-benzyl-propionic acid
-
Homo sapiens
3.4.17.23 3-[[1-(2-acetylamino-4-methyl-pentanoylamino)-2-phenylethyl]-hydroxy-phosphinoyl]-2-benzyl-propionic acid
-
Homo sapiens
3.4.17.23 3-[[1-(2-acetylamino-6-amino-hexanoyl)-pyrrolidin-2-yl]-hydroxy-phosphinoyl]-2-benzyl-propionic acid
-
Homo sapiens
3.4.17.23 3-[[1-(2-acetylamino-propionyl)-pyrrolidin-2-yl]-hydroxyphosphinoyl]-2-benzyl-propionic acid
-
Homo sapiens
3.4.17.23 4-acetylamino-5-[2-[(2-carboxy-3-phenyl-propyl)-hydroxyphosphinoyl]-pyrrolidin-1-yl]-5-oxo-pentanoic acid
-
Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.4.17.23 Homo sapiens Q9BYF1
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.17.23 angiotensin II + H2O
-
Homo sapiens angiotensin-(1-7) + Phe
-
?

Synonyms

EC Number Synonyms Comment Organism
3.4.17.23 ACE2
-
Homo sapiens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
3.4.17.23 0.00000035
-
3-[[1-(2-acetylamino-3-methyl-butyryl)-pyrrolidin-2-yl]-hydroxy-phosphinoyl]-2-benzyl-propionic acid
-
Homo sapiens
3.4.17.23 0.0000004
-
3-([1-[2-acetylamino-3-(1H-imidazol-4-yl)-propionyl]-pyrrolidin-2-yl]-hydroxy-phosphinoyl)-2-(3-phenyl-isoxazol-5-ylmethyl)-propionic acid
-
Homo sapiens
3.4.17.23 0.00000125
-
3-[[1-(2-acetylamino-4-methyl-pentanoyl)-pyrrolidin-2-yl]-hydroxy-phosphinoyl]-2-(3-phenyl-isoxazol-5-ylmethyl)-propionic acid
-
Homo sapiens
3.4.17.23 0.0000021
-
3-([1-[2-acetylamino-3-(1H-imidazol-4-yl)-propionyl]-pyrrolidin-2-yl]-hydroxy-phosphinoyl)-2-benzyl-propionic acid
-
Homo sapiens
3.4.17.23 0.0000052
-
3-([1-[2-acetylamino-3-(4-hydroxy-phenyl)-propionyl]-pyrrolidin-2-yl]-hydroxy-phosphinoyl)-2-benzyl-propionic acid
-
Homo sapiens
3.4.17.23 0.0000052
-
3-[[1-(2-acetylamino-3-phenyl-propionyl)-pyrrolidin-2-yl]-hydroxy-phosphinoyl]-2-benzyl-propionic acid
-
Homo sapiens
3.4.17.23 0.0000065
-
3-[[1-(2-acetylamino-6-amino-hexanoyl)-pyrrolidin-2-yl]-hydroxy-phosphinoyl]-2-benzyl-propionic acid
-
Homo sapiens
3.4.17.23 0.0000066
-
3-[[1-(2-acetylamino-4-methyl-pentanoyl)-pyrrolidin-2-yl]-hydroxy-phosphinoyl]-2-benzyl-propionic acid
-
Homo sapiens
3.4.17.23 0.000007
-
4-acetylamino-5-[2-[(2-carboxy-3-phenyl-propyl)-hydroxyphosphinoyl]-pyrrolidin-1-yl]-5-oxo-pentanoic acid
-
Homo sapiens
3.4.17.23 0.0000075
-
3-[[1-(2-acetylamino-propionyl)-pyrrolidin-2-yl]-hydroxyphosphinoyl]-2-benzyl-propionic acid
-
Homo sapiens
3.4.17.23 0.00022
-
3-([1-[2-acetylamino-3-(1H-imidazol-4-yl)-propionylamino]-3-methyl-butyl]-hydroxy-phosphinoyl)-2-(3-phenyl-isoxazol-5-ylmethyl)-propionic acid
-
Homo sapiens
3.4.17.23 0.0003
-
2-[(2-carboxy-3-phenyl-propyl)-hydroxy-phosphinoyl]-pyrrolidine-1-carboxylic acid benzyl ester
-
Homo sapiens
3.4.17.23 0.0008
-
3-([1-[2-acetylamino-3-(1H-imidazol-4-yl)-propionylamino]-3-methyl-butyl]-hydroxy-phosphinoyl)-2-benzyl-propionic acid
-
Homo sapiens
3.4.17.23 0.00092
-
3-[[1-(2-acetylamino-4-methyl-pentanoylamino)-2-phenylethyl]-hydroxy-phosphinoyl]-2-benzyl-propionic acid
-
Homo sapiens
3.4.17.23 0.003
-
2-[(2-carboxy-4-methyl-pentyl)-hydroxy-phosphinoyl]-pyrrolidine-1-carboxylic acid benzyl ester
-
Homo sapiens
3.4.17.23 0.003
-
2-[(2-carboxy-propyl)-hydroxy-phosphinoyl]-pyrrolidine-1-carboxylic acid benzyl ester
-
Homo sapiens
3.4.17.23 0.008
-
2-benzyl-3-[(1-benzyloxycarbonylamino-3-methyl-butyl)-hydroxy-phosphinoyl]-propionic acid
-
Homo sapiens
3.4.17.23 0.01
-
2-benzyl-3-[(1-benzyloxycarbonylamino-ethyl)-hydroxy-phosphinoyl]-propionic acid Ki above 0.01 mM Homo sapiens
3.4.17.23 0.01
-
2-benzyl-3-[(1-benzyloxycarbonylamino-2-phenyl-ethyl)-hydroxy-phosphinoyl]-propionic acid Ki above 0.01 mM Homo sapiens
3.4.17.23 0.01
-
3-[(1-amino-ethyl)-hydroxy-phosphinoyl]-2-benzyl-propionic acid Ki above 0.01 mM Homo sapiens
3.4.17.23 0.01
-
3-[(1-amino-2-phenyl-ethyl)-hydroxy-phosphinoyl]-2-benzylpropionic acid Ki above 0.01 mM Homo sapiens
3.4.17.23 0.01
-
3-[(1-amino-3-methyl-butyl)-hydroxy-phosphinoyl]-2-benzylpropionic acid Ki above 0.01 mM Homo sapiens
3.4.17.23 0.01
-
2-benzyl-3-(hydroxy-pyrrolidin-2-yl-phosphinoyl)-propionic acid Ki above 0.01 mM Homo sapiens