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Literature summary extracted from
- 3beta-Hydroxysteroid dehydrogenase/5-ene-4-ene isomerase mRNA expression in rat brain: effect of pseudopregnancy and traumatic brain injury (2007), J. Steroid Biochem. Mol. Biol., 104, 293-300.
Application
| EC Number | Application | Comment | Organism |
|---|---|---|---|
| 1.1.1.145 | medicine | twenty-four hours after bilateral contusion of the medial prefrontal cortex, similar levels of 3beta-hydroxysteroid dehydrogenase mRNA expression are observed in males and pseudopregnant females in the non-injured group, with a significant decrease in the 3beta-hydroxysteroid dehydrogenase mRNA expression in the contusion site within the frontal cortex in both males and pseudopregnant females. In all other regions analyzed, 3beta-hydroxysteroid dehydrogenase mRNA expression is not affected by traumatic brain injury and there is no difference between males and pseudopregnant females | Rattus norvegicus |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.1.1.145 | Rattus norvegicus | P22071 | - |
- |
| 5.3.3.1 | Rattus norvegicus | P22071 | Sprague-Dawley rats | - |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.1.1.145 | brain | twenty-four hours after bilateral contusion of the medial prefrontal cortex, similar levels of 3beta-hydroxysteroid dehydrogenase mRNA expression are observed in males and pseudopregnant females in the non-injured group, with a significant decrease in the 3beta-hydroxysteroid dehydrogenase mRNA expression in the contusion site within the frontal cortex in both males and pseudopregnant females. In all other regions analyzed, 3beta-hydroxysteroid dehydrogenase mRNA expression is not affected by traumatic brain injury and there is no difference between males and pseudopregnant females | Rattus norvegicus | - |
| 5.3.3.1 | brain | enzyme expression analysis in male and pseudopregnant female rat brain, in situ hybridization, overview, strong expression in olfactory bulb, striatum, cortex, thalamus, hypothalamus, septum, habenula, hippocampus and cerebellum, pseudopregnancy has no effect on enzyme expression in brain, effect of lesions, overview | Rattus norvegicus | - |
| 5.3.3.1 | brain cortex | - |
Rattus norvegicus | - |
| 5.3.3.1 | cerebellum | - |
Rattus norvegicus | - |
| 5.3.3.1 | habenula | - |
Rattus norvegicus | - |
| 5.3.3.1 | hippocampus | - |
Rattus norvegicus | - |
| 5.3.3.1 | hypothalamus | - |
Rattus norvegicus | - |
| 5.3.3.1 | olfactory bulb | - |
Rattus norvegicus | - |
| 5.3.3.1 | septum pellucidum | - |
Rattus norvegicus | - |
| 5.3.3.1 | striatum | - |
Rattus norvegicus | - |
| 5.3.3.1 | thalamus | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 5.3.3.1 | additional information | bifunctional enzyme possessing 3-beta-hydroxy-DELTA5-steroid dehydrogenase, EC 1.1.1.145, and steroid DELTA-isomerase activity | Rattus norvegicus | ? | - |
? |  |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 5.3.3.1 | 3beta-hydroxysteroid dehydrogenase/5-ene-4-ene isomerase | - |
Rattus norvegicus |
| 5.3.3.1 | More | cf. EC 1.1.1.51 and EC 1.1.1.145 | Rattus norvegicus |
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