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Literature summary extracted from

  • Padia, S.H.; Kemp, B.A.; Howell, N.L.; Fournie-Zaluski, M.C.; Roques, B.P.; Carey, R.M.
    Conversion of renal angiotensin II to angiotensin III is critical for AT2 receptor-mediated natriuresis in rats (2008), Hypertension, 51, 460-465.
    View publication on PubMed

Application

EC Number Application Comment Organism
3.4.11.7 medicine results suggest that APA, APN, AngIII and AT2R are potentially important targets for disorders characterized by Na+ and fluid retention, such as hypertension and congestive heart failure Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.11.7 3-amino-4-thio-butyl sulfonic acid EC33, specific and selective APA inhibitor Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.11.7 membrane
-
Rattus norvegicus 16020
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.4.11.7 Zn2+
-
Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.11.7 angiotensin II + H2O Rattus norvegicus angiotensin II: Asp-Arg-Val-Tyr-Ile-His-Pro-Phe aspartic acid + angiotensin III angiotensin III: Arg-Val-Tyr-Ile-His-Pro-Phe ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.11.7 Rattus norvegicus
-
Sprague Dawley rat
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.11.7 endothelial cell glomerular endothelial cell Rattus norvegicus
-
3.4.11.7 kidney
-
Rattus norvegicus
-
3.4.11.7 mesangial cell
-
Rattus norvegicus
-
3.4.11.7 nephron
-
Rattus norvegicus
-
3.4.11.7 podocyte
-
Rattus norvegicus
-
3.4.11.7 renal tubule renal proximal tubule Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.11.7 angiotensin II + H2O angiotensin II: Asp-Arg-Val-Tyr-Ile-His-Pro-Phe Rattus norvegicus aspartic acid + angiotensin III angiotensin III: Arg-Val-Tyr-Ile-His-Pro-Phe ?

Synonyms

EC Number Synonyms Comment Organism
3.4.11.7 aminopeptidase A
-
Rattus norvegicus

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
3.4.11.7 additional information
-
additional information inhibition constant of 3-amino-4-thio-butyl sulfonic acid for aminopeptidase A: 0.29 microM/L Rattus norvegicus