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Literature summary extracted from
- Jacques Benoit lecture: the neuroendocrine view of the angiotensin and apelin systems (2008), J. Neuroendocrinol., 20, 279-289.
Application
| EC Number | Application | Comment | Organism |
|---|---|---|---|
| 3.4.11.7 | medicine | APA is a new potential therapeutic target for the treatment of certain forms of hypertension | Rattus norvegicus |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.11.7 | amastatin | - |
Rattus norvegicus |  |
| 3.4.11.7 | bestatin | - |
Rattus norvegicus | |
| 3.4.11.7 | EC33 | - |
Rattus norvegicus | |
| 3.4.11.7 | RB150 | - |
Rattus norvegicus | |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 3.4.11.7 | membrane | - |
Rattus norvegicus | 16020 | - |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.11.7 | Zn2+ | - |
Rattus norvegicus | |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 3.4.11.7 | 120000 | - |
monomer | Rattus norvegicus |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.11.7 | angiotensin II + H2O | Rattus norvegicus | angiotensin II: Asp-Arg-Val-Tyr-Ile-His-Pro-Phe | aspartic acid + angiotensin III | angiotensin III: Arg-Val-Tyr-Ile-His-Pro-Phe | ? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.4.11.7 | Rattus norvegicus | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.4.11.7 | brain | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.11.7 | angiotensin II + H2O | angiotensin II: Asp-Arg-Val-Tyr-Ile-His-Pro-Phe | Rattus norvegicus | aspartic acid + angiotensin III | angiotensin III: Arg-Val-Tyr-Ile-His-Pro-Phe | ? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.4.11.7 | aminopeptidase A | - |
Rattus norvegicus |
Ki Value [mM]
| EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 3.4.11.7 | 0.00025 | - |
EC33 | - |
Rattus norvegicus | |
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Release 2023.1 (January 2023)
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