Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Bosinski, T.J.; El Solh, A.A.
    Recombinant factor VIIa, its clinical properties, and the tissue factor pathway of coagulation (2006), Mini Rev. Med. Chem., 6, 1111-1117.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.4.21.21 vitamin K dependent on, activation cycle, overview Homo sapiens

Application

EC Number Application Comment Organism
3.4.21.21 medicine the enzyme is clinically used to treat hemophilia, clinical trials, overview Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.21.21 genetic localization at 13q34, cloning from a liver gene library, expression in BHK cells with secretion to the medium Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.4.21.21 Ca2+ one FVIIa molecule binds 8 Ca2+ in the epidermal growth factor-like and the gamma-carboxyglutamic acid-rich domains Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.4.21.21 50000
-
 x * 50000, zymogen FVII, SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.21.21 Factor X + H2O Homo sapiens the enzyme is involved in the coagulation cascade, pathways, overview Factor Xa + ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.21 Homo sapiens
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
3.4.21.21 glycoprotein N-glycosylation at Asp145 and Asp322, and O-glycosylation Homo sapiens
3.4.21.21 proteolytic modification zymogen factor VII is activated by thrombin Homo sapiens

Purification (Commentary)

EC Number Purification (Comment) Organism
3.4.21.21 recombinant FVII zymogen from BHK cell medium Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.21 Factor X + H2O
-
 Homo sapiens Factor Xa + ?
-
 ?
3.4.21.21 Factor X + H2O the enzyme is involved in the coagulation cascade, pathways, overview Homo sapiens Factor Xa + ?
-
 ?

Subunits

EC Number Subunits Comment Organism
3.4.21.21 ? x * 50000, zymogen FVII, SDS-PAGE Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
3.4.21.21 factor VIIa
-
 Homo sapiens
3.4.21.21 FVIIa
-
 Homo sapiens
3.4.21.21 vitamin K dependent clotting factor
-
 Homo sapiens