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Literature summary extracted from

  • Seujange, Y.; Eiam-Ong, S.; Tirawatnapong, T.; Eiam-Ong, S.
    Role of angiotensin II on dihydrofolate reductase, GTP-cyclohydrolase 1 and nitric oxide synthase expressions in renal ischemia-reperfusion (2008), Am. J. Nephrol., 28, 692-700.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.5.4.16 additional information GTP-CH 1 mRNA and protein expression is unaltered by renal ischemia-reperfusion Rattus norvegicus

Application

EC Number Application Comment Organism
1.5.1.3 medicine renal ischemia-reperfusion decreases dihydrofolate reductase mRNA and protein levels, both of which are restored by angiotensin-converting enzyme inhibitor or angiotensin II receptor blocker, whereas GTP-cyclohydrolase 1 expression is unaltered. Renal ischemia-reperfusion suppresses endothelial nitric oxide synthase dimer while enhancing the monomer and augments inducible nitric oxide synthase mRNA, total inducible nitric oxide synthase protein and monomer, which are attenuated by angiotensin-converting enzyme inhibitor or angiotensin II receptor blocker Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
1.5.1.3 Rattus norvegicus Q920D2
-
-
3.5.4.16 Rattus norvegicus P22288
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.5.1.3 kidney
-
 Rattus norvegicus
-
3.5.4.16 kidney
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.5.4.16 GTP + H2O
-
 Rattus norvegicus formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.5.4.16 GTP-cyclohydrolase 1
-
 Rattus norvegicus
3.5.4.16 GTPCH1
-
 Rattus norvegicus