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Literature summary extracted from

  • Lorne, E.; Zmijewski, J.W.; Zhao, X.; Liu, G.; Tsuruta, Y.; Park, Y.J.; Dupont, H.; Abraham, E.
    Role of extracellular superoxide in neutrophil activation: interactions between xanthine oxidase and TLR4 induce proinflammatory cytokine production (2008), Am. J. Physiol., 294, C985-C993.
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.17.3.2 cell surface co-localization of the enzyme with Toll-like receptor-4 on the cell surface membrane, inhibited by heparin Mus musculus 9986
-
1.17.3.2 extracellular co-localization of the enzyme with Toll-like receptor-4 on the cell surface membrane, inhibited by heparin Mus musculus
-
-
1.17.3.2 membrane co-localization of the enzyme with Toll-like receptor-4 on the cell surface membrane, inhibited by heparin Mus musculus 16020
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.17.3.2 additional information Mus musculus the enzyme interacts with the Toll-like receptor-4, TLR-4, inducing proinflammatory cytokine production, extracellular superoxide production by the enzyme leads to nuclear translocation of nuclear factor-kappaB and increased neutrophil production of the NFkappaB-dependent cytokines tumor necrosis factor-alpha and macrophage inhibitory protein-2 mediated by TLR-4, overview ?
-
?
1.17.3.2 xanthine + H2O + O2 Mus musculus
-
urate + H2O2
-
?

Organism

EC Number Organism UniProt Comment Textmining
1.17.3.2 Mus musculus
-
C57/BL6, C57/10Scn, and C57/10J mice
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.17.3.2 neutrophil from bone marrow of different samples Mus musculus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.17.3.2 additional information
-
measurement of cytokine production and factor translocation, overview Mus musculus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.17.3.2 additional information the enzyme interacts with the Toll-like receptor-4, TLR-4, inducing proinflammatory cytokine production, extracellular superoxide production by the enzyme leads to nuclear translocation of nuclear factor-kappaB and increased neutrophil production of the NFkappaB-dependent cytokines tumor necrosis factor-alpha and macrophage inhibitory protein-2 mediated by TLR-4, overview Mus musculus ?
-
?
1.17.3.2 xanthine + H2O + O2
-
Mus musculus urate + H2O2
-
?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.17.3.2 37
-
assay at Mus musculus