EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
1.17.3.2 | cell surface | co-localization of the enzyme with Toll-like receptor-4 on the cell surface membrane, inhibited by heparin | Mus musculus | 9986 | - |
1.17.3.2 | extracellular | co-localization of the enzyme with Toll-like receptor-4 on the cell surface membrane, inhibited by heparin | Mus musculus | - |
- |
1.17.3.2 | membrane | co-localization of the enzyme with Toll-like receptor-4 on the cell surface membrane, inhibited by heparin | Mus musculus | 16020 | - |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.17.3.2 | additional information | Mus musculus | the enzyme interacts with the Toll-like receptor-4, TLR-4, inducing proinflammatory cytokine production, extracellular superoxide production by the enzyme leads to nuclear translocation of nuclear factor-kappaB and increased neutrophil production of the NFkappaB-dependent cytokines tumor necrosis factor-alpha and macrophage inhibitory protein-2 mediated by TLR-4, overview | ? | - |
? | |
1.17.3.2 | xanthine + H2O + O2 | Mus musculus | - |
urate + H2O2 | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.17.3.2 | Mus musculus | - |
C57/BL6, C57/10Scn, and C57/10J mice | - |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
1.17.3.2 | neutrophil | from bone marrow of different samples | Mus musculus | - |
EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|---|
1.17.3.2 | additional information | - |
measurement of cytokine production and factor translocation, overview | Mus musculus |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.17.3.2 | additional information | the enzyme interacts with the Toll-like receptor-4, TLR-4, inducing proinflammatory cytokine production, extracellular superoxide production by the enzyme leads to nuclear translocation of nuclear factor-kappaB and increased neutrophil production of the NFkappaB-dependent cytokines tumor necrosis factor-alpha and macrophage inhibitory protein-2 mediated by TLR-4, overview | Mus musculus | ? | - |
? | |
1.17.3.2 | xanthine + H2O + O2 | - |
Mus musculus | urate + H2O2 | - |
? |
EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|---|
1.17.3.2 | 37 | - |
assay at | Mus musculus |