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Literature summary extracted from

  • Dobrzyn, P.; Sampath, H.; Dobrzyn, A.; Miyazaki, M.; Ntambi, J.M.
    Loss of stearoyl-CoA desaturase 1 inhibits fatty acid oxidation and increases glucose utilization in the heart (2008), Am. J. Physiol. Endocrinol. Metab., 294, E357-E364.
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
1.14.19.1 additional information SCD1 knockout mice show reduced levels of fatty acid transport proteins and lipid content on the heart, as well as decreased fatty acid beta-oxidation and a downregulated peroxisome proliferator-activated receptor-alpha, PPARalpha, pathway, the signalling pathways involved in glucose transport are affected, phenotype, overview Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.14.19.1 microsome
-
 Mus musculus
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.19.1 stearoyl-CoA + ferrocytochrome b5 + O2 + H+ Mus musculus rate-limiting enzyme involved in the synthesis of monounsaturated fatty acids, deficiency of isozyme SCD1 leads to activation of the metabolic pathways that promote fatty acid beta-oxidation in mice, enzyme regulation in the heart in a hormone-dependent fashion, overview oleoyl-CoA + ferricytochrome b5 + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.19.1 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.19.1 heart isozyme SCD1, SCD2, and SCD4 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.19.1 stearoyl-CoA + ferrocytochrome b5 + O2 + H+
-
 Mus musculus oleoyl-CoA + ferricytochrome b5 + H2O
-
 ?
1.14.19.1 stearoyl-CoA + ferrocytochrome b5 + O2 + H+ rate-limiting enzyme involved in the synthesis of monounsaturated fatty acids, deficiency of isozyme SCD1 leads to activation of the metabolic pathways that promote fatty acid beta-oxidation in mice, enzyme regulation in the heart in a hormone-dependent fashion, overview Mus musculus oleoyl-CoA + ferricytochrome b5 + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.19.1 SCD1
-
 Mus musculus
1.14.19.1 stearoyl-CoA desaturase 1
-
 Mus musculus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.14.19.1 7.2
-
 assay at Mus musculus

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.19.1 ferrocytochrome b5
-
 Mus musculus