Literature summary extracted from

Rakowitz, D.; Piccolruaz, G.; Pirker, C.; Matuszczak, B.
Novel aldose reductase inhibitors derived from 6-[[(diphenylmethylene)amino]oxy]hexanoic acid (2007), Arch. Pharm., 340, 202-208.

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
1.1.1.21	6-[[(di(2,4-dimethoxyphenyl)methylidene)amino]oxy]hexanoic acid	-	Homo sapiens
1.1.1.21	6-[[(di(3,5-dimethoxyphenyl)methylidene)amino]oxy]hexanoic acid	-	Homo sapiens
1.1.1.21	6-[[(di(4-methoxy-3-methylphenyl)methylidene)amino]oxy]hexanoic acid	-	Homo sapiens

Organism

EC Number	Organism	UniProt	Comment	Textmining
1.1.1.21	Homo sapiens	-	-	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
1.1.1.21	DL-glyceraldehyde + NAD(P)H	-	Homo sapiens	glycerol + NAD(P)+	-	?

Ki Value [mM]

EC Number	Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
1.1.1.21	0.00292	-	6-[[(di(4-methoxy-3-methylphenyl)methylidene)amino]oxy]hexanoic acid	pH 6.8, 37°C	Homo sapiens
1.1.1.21	0.00297	-	6-[[(di(2,4-dimethoxyphenyl)methylidene)amino]oxy]hexanoic acid	pH 6.8, 37°C	Homo sapiens
1.1.1.21	0.00299	-	6-[[(di(3,5-dimethoxyphenyl)methylidene)amino]oxy]hexanoic acid	pH 6.8, 37°C	Homo sapiens

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Release 2023.1 (January 2023)